D4R antagonis-2
D4R antagonist-2 is a potent and selective D4R antagonist with an IC50 of 6.52 µM. D4R antagonist-2 displays very favorable in vitro PK parameters and has good brain penetration. D4R antagonist-2 has the potential for the research of Parkinson’s disease.
For research use only. We do not sell to patients.
- CAS No.: 2846077-70-9
- Formula: C21H23ClF2N2O2
- Molecular Weight:408.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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D4 Receptor 6.87 μM (IC50) |
D4R antagonist-2 (compound 11a) shows good activity with an Ki of 299.4 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| rat cassette (0.25 mpk) | 11a |
| CL (ml/min/kg) | 22.0 |
| T1/2 (h) | 4.4 |
| C0 (ng/ml) | 91 |
| Vss (L/kg) | 5.5 |
| AUC (h*ng/mL) | 747 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:rats[1]
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Dosage:
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Administration:i.v.
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Result:Displayed very favorable in vitro PK parameters and was brain pentrent (Kp=2.9).
Chemical Information
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CAS No. 2846077-70-9
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Molecular Weight 408.87
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Formula C21H23ClF2N2O2
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SMILES
CC1=C(C=CC=C1NC(CN2CCC(CC2)OCC3=CC=C(C(F)=C3)F)=O)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
D4R antagonis-2 Related Classifications
HY-145906 Related Classifications
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