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PRMT5/EGFR-IN-1

PRMT5/EGFR-IN-1 (Compound 10p) is an orally active dual PRMT5/EGFR inhibitor, with IC50s of 15.47 and 19.31 μM, respectively. PRMT5/EGFR-IN-1 exhibits antiproliferative activity against A549, MCF7, HeLa, and MDA-MB-231 cell lines. PRMT5/EGFR-IN-1 has favorable in vivo PK and PD properties. PRMT5/EGFR-IN-1 can significantly inhibit the growth of MCF7 orthotopic xenograft tumors.

For research use only. We do not sell to patients.

  • CAS No.: 3034402-59-7
  • Formula: C27H22F6N2O2
  • Molecular Weight:520.47
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • PRMT5/EGFR-IN-1 Chemical Structure
    PRMT5/EGFR-IN-1 Chemical Structure
CAS No.: 3034402-59-7
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Use of MCE Products

All EGFR Isoforms

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All Histone Methyltransferase Isoforms

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100 mg

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  • PRMT5/EGFR-IN-1 Chemical Structure
    PRMT5/EGFR-IN-1 Chemical Structure
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  • PRMT5/EGFR-IN-1