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Etedesiran

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Etedesiran is a component of the AOC drug Delpacibart etedesiran (HY-177565), formed by the reaction of an siRNA that induces cleavage of mRNA encoding myotonic dystrophy protein kinase (MTPK or DMPK) with SMCC linker (HY-42360). Etedesiran carries a maleimide group at its terminus, which can react with cysteine or lysine and is used for the synthesis of AOC drugs. Etedesiran is applicable to research related to myotonic dystrophy type 1.

For research use only. We do not sell to patients.

  • Purity : 93.16%
  • Molecular Weight:13699.70
  • Storage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Etedesiran Chemical Structure
    Etedesiran Chemical Structure
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

Use of MCE Products

All Antibody-Oligonucleotide Conjugates (AOCs) Isoforms

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  • Etedesiran Chemical Structure
    Etedesiran Chemical Structure RNA (Cm-sp-Cm-sp-Cm-Um-Am-Gm-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)C-Um-Gm-Um-Cm-Um-Um-Cm-Gm-sp-Am-sp-Am), 5′-[6-[[[4-[(3-mercapto-2,5-dioxo-1-pyrrolidinyl)methyl]cyclohexyl]carbonyl]amino]hexyl hydrogen phosphate], complex with RNA (Um-sp-(2′-deoxy-2′-fluoro)U-sp-Cm-Gm-Am-(2′-deoxy-2′-fluoro)A-Gm-Am-Cm-Am-Gm-Um-Um-(2′-deoxy-2′-fluoro)C-Um-(2′-deoxy-2′-fluoro)A-Gm-Gm-Gm-sp-Um-sp-Um)
    1/16
  • RNA (Cm-sp-Cm-sp-Cm-Um-Am-Gm-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)C-Um-Gm-Um-Cm-Um-Um-Cm-Gm-sp-Am-sp-Am), 5′-[6-[[[4-[(3-mercapto-2,5-dioxo-1-pyrrolidinyl)methyl]cyclohexyl]carbonyl]amino]hexyl hydrogen phosphate], complex with RNA (Um-sp-(2′-deoxy-2′-fluoro)U-sp-Cm-Gm-Am-(2′-deoxy-2′-fluoro)A-Gm-Am-Cm-Am-Gm-Um-Um-(2′-deoxy-2′-fluoro)C-Um-(2′-deoxy-2′-fluoro)A-Gm-Gm-Gm-sp-Um-sp-Um)