2. Antibody-drug Conjugate/ADC Related Epigenetics
  3. Antibody-Oligonucleotide Conjugates (AOCs) Small Interfering RNA (siRNA)
  4. Etedesiran

Etedesiran is a component of the AOC drug Delpacibart etedesiran (HY-177565), formed by the reaction of an siRNA that induces cleavage of mRNA encoding myotonic dystrophy protein kinase (MTPK or DMPK) with SMCC linker (HY-42360). Etedesiran carries a maleimide group at its terminus, which can react with cysteine or lysine and is used for the synthesis of AOC drugs. Etedesiran is applicable to research related to myotonic dystrophy type 1.

For research use only. We do not sell to patients.

RNA (Cm-sp-Cm-sp-Cm-Um-Am-Gm-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)C-Um-Gm-Um-Cm-Um-Um-Cm-Gm-sp-Am-sp-Am), 5′-[6-[[[4-[(3-mercapto-2,5-dioxo-1-pyrrolidinyl)methyl]cyclohexyl]carbonyl]amino]hexyl hydrogen phosphate], complex with RNA (Um-sp-(2′-deoxy-2′-fluoro)U-sp-Cm-Gm-Am-(2′-deoxy-2′-fluoro)A-Gm-Am-Cm-Am-Gm-Um-Um-(2′-deoxy-2′-fluoro)C-Um-(2′-deoxy-2′-fluoro)A-Gm-Gm-Gm-sp-Um-sp-Um)

Etedesiran Chemical Structure

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Based on 1 publication(s) in Google Scholar

Etedesiran Related Antibodies

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Description

Etedesiran is a component of the AOC drug Delpacibart etedesiran (HY-177565), formed by the reaction of an siRNA that induces cleavage of mRNA encoding myotonic dystrophy protein kinase (MTPK or DMPK) with SMCC linker (HY-42360). Etedesiran carries a maleimide group at its terminus, which can react with cysteine or lysine and is used for the synthesis of AOC drugs. Etedesiran is applicable to research related to myotonic dystrophy type 1[1].

In Vivo

Etedesiran can be used for synthesizing Delpacibart etedesiran (HY-177565), which dose-dependently and significantly reduces total DMPK mRNA levels in multiple skeletal muscles, hearts, and gastrointestinal tracts of untreated cynomolgus monkeys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

13699.70

Appearance

Solid

Color

White to light yellow

SMILES

[Etedesiran]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Etedesiran Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EtedesiranAntibody-Oligonucleotide Conjugates (AOCs)Small Interfering RNA (siRNA)gastrointestinal tractheartmutant DM1 protein kinase mRNAcynomolgus monkeysmuscle cellmuscleblind-like proteinstransferrin receptor 1patient-derived myotubesmyotonic dystrophy type 1skeletal musclesInhibitorinhibitorinhibit

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