1. Neuronal Signaling
    Stem Cell/Wnt
  2. γ-secretase
  3. BPN-15606 besylate

BPN-15606 besylate 

Cat. No.: HY-117482A
Handling Instructions

BPN-15606 besylate is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 besylate significantly lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 besylate has acceptable PK/PD properties, including bioavailability, half-life, and clearance.

For research use only. We do not sell to patients.

BPN-15606 besylate Chemical Structure

BPN-15606 besylate Chemical Structure

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Description

BPN-15606 besylate is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 besylate significantly lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 besylate has acceptable PK/PD properties, including bioavailability, half-life, and clearance[1].

IC50 & Target

γ-secretase[1]

In Vitro

BPN-15606 besylate (oral administration; 10 mg/kg, 25 mg/kg and 50 mg/kg; 7 days) shows excellent dose-dependent efficacy in both plasma and brain on lowering of Aβ42 and Aβ40 levels in mice[1].
BPN-15606 besylate (oral administration; 5 mg/kg, 25 mg/kg and 50 mg/kg; 9 days) dose-dependently reduces CSF on lowering of Aβ42 and Aβ40 levels in rats[1].
BPN-15606 besylate (oral administration; 25 mg/kg; single dose) shows a robust effect on both brain and plasma Aβ 42 and Aβ40 levels, which begins approximately 30–60 minutes following the single dose administration and lasted for ≥24 hours in C57BL/6 mice[1].

Molecular Weight

576.64

Formula

C₂₉H₂₉FN₆O₄S

SMILES

O=S(C1=CC=CC=C1)(O)=O.CC2=CC(C3=NC(OC)=C(N4C=C(C)N=C4)C=C3)=NN=C2N[[email protected]](C5=CC=C(F)C=C5)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
BPN-15606 besylate
Cat. No.:
HY-117482A
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