1. Anti-infection
  2. Parasite
  3. AN7973

AN7973 

Cat. No.: HY-128337
Handling Instructions

AN7973 is the 6-carboxamide benzoxaborole, blocks intracellular parasite development and inhibits Cryptosporidium growth. AN7973 is orally active, possesses favorable safety, stability, and PK parameters, and is an exciting drug candidate for treating cryptosporidiosis.

For research use only. We do not sell to patients.

AN7973 Chemical Structure

AN7973 Chemical Structure

CAS No. : 1620899-32-2

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Description

AN7973 is the 6-carboxamide benzoxaborole, blocks intracellular parasite development and inhibits Cryptosporidium growth. AN7973 is orally active, possesses favorable safety, stability, and PK parameters, and is an exciting drug candidate for treating cryptosporidiosis.

In Vivo

AN7973 (oral gavage; 5-25 mg/kg; once daily) is efficacious in murine models of both acute and chronic infection by rapidly eliminating C.parvum in vivo[1].
AN7973 (oral gavage; 5 mg/kg, 10 mg/kg, 6.67 mg/kg; once daily, twice daily, three times daily) reduces C.parvum fecal shedding, diarrhea, and dehydration in a neonatal calf model (closely mimics that seen in infants) of cryptosporidiosis[1].
AN7973 possesses favorable safety, stability, and PK parameters as an exciting drug candidate for treating cryptosporidiosis[1].

Animal Model: Four to five weeks NOD scid gamma mice (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ)(NSG) with chronic Cryptosporidium infection[1]
Dosage: 10 mg/kg, 20 mg/kg
Administration: Oral gavage; 10 mg/kg, 20 mg/kg; once daily
Result: Reduced parasite shedding by >99% at a dose of 25 mg/kg and by >90% at a dose of 10 mg/kg administration.
Animal Model: Four-week-old female C57BL/6 IFN-γ−/− mice with acute Cryptosporidium infection[1]
Dosage: 5 mg/kg, 10 mg/kg, 25 mg/kg
Administration: Oral gavage; 5 mg/kg, 10 mg/kg, 25 mg/kg; once dairy
Result: Eliminated C.parvums at a dose-dependent efficacy.
Animal Model: One-day-old to two-day-old Holstein bull Neonatal calf model of cryptosporidiosis[1]
Dosage: 5 mg/kg, 10 mg/kg, 6.67 mg/kg
Administration: Oral gavage; 5 mg/kg, 10 mg/kg, 6.67 mg/kg; once daily, twice daily, three times daily
Result: Curtailed parasite shedding and completely eliminated diarrhea.
Molecular Weight

381.62

Formula

C₁₉H₁₇BClN₃O₃

CAS No.

1620899-32-2

SMILES

ClC1=CC(N2C=CC=N2)=CC=C1C(NC3=CC=C(C(C)(C)OB4O)C4=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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