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  4. AN7973

AN7973 

Cat. No.: HY-128337 Purity: 99.70%
COA Handling Instructions

AN7973 is the 6-carboxamide benzoxaborole, blocks intracellular parasite development and inhibits Cryptosporidium growth. AN7973 is orally active, possesses favorable safety, stability, and PK parameters, and is an exciting agent candidate for treating cryptosporidiosis.

For research use only. We do not sell to patients.

AN7973 Chemical Structure

AN7973 Chemical Structure

CAS No. : 1620899-32-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 385 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 385 In-stock
Solid
5 mg USD 350 In-stock
10 mg USD 580 In-stock
25 mg USD 1100 In-stock
50 mg USD 1700 In-stock
100 mg USD 2500 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma

  • Biological Activity

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Description

AN7973 is the 6-carboxamide benzoxaborole, blocks intracellular parasite development and inhibits Cryptosporidium growth. AN7973 is orally active, possesses favorable safety, stability, and PK parameters, and is an exciting agent candidate for treating cryptosporidiosis.

In Vivo

AN7973 (oral gavage; 5-25 mg/kg; once daily) is efficacious in murine models of both acute and chronic infection by rapidly eliminating C.parvum in vivo[1].
AN7973 (oral gavage; 5 mg/kg, 10 mg/kg, 6.67 mg/kg; once daily, twice daily, three times daily) reduces C.parvum fecal shedding, diarrhea, and dehydration in a neonatal calf model (closely mimics that seen in infants) of cryptosporidiosis[1].
AN7973 possesses favorable safety, stability, and PK parameters as an exciting drug candidate for treating cryptosporidiosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four to five weeks NOD scid gamma mice (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ)(NSG) with chronic Cryptosporidium infection[1]
Dosage: 10 mg/kg, 20 mg/kg
Administration: Oral gavage; 10 mg/kg, 20 mg/kg; once daily
Result: Reduced parasite shedding by >99% at a dose of 25 mg/kg and by >90% at a dose of 10 mg/kg administration.
Animal Model: Four-week-old female C57BL/6 IFN-γ−/− mice with acute Cryptosporidium infection[1]
Dosage: 5 mg/kg, 10 mg/kg, 25 mg/kg
Administration: Oral gavage; 5 mg/kg, 10 mg/kg, 25 mg/kg; once dairy
Result: Eliminated C.parvums at a dose-dependent efficacy.
Animal Model: One-day-old to two-day-old Holstein bull Neonatal calf model of cryptosporidiosis[1]
Dosage: 5 mg/kg, 10 mg/kg, 6.67 mg/kg
Administration: Oral gavage; 5 mg/kg, 10 mg/kg, 6.67 mg/kg; once daily, twice daily, three times daily
Result: Curtailed parasite shedding and completely eliminated diarrhea.
Molecular Weight

381.62

Appearance

Solid

Formula

C19H17BClN3O3
CAS No.
SMILES

ClC1=CC(N2C=CC=N2)=CC=C1C(NC3=CC=C(C(C)(C)OB4O)C4=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (327.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6204 mL 13.1020 mL 26.2041 mL
5 mM 0.5241 mL 2.6204 mL 5.2408 mL
10 mM 0.2620 mL 1.3102 mL 2.6204 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.45 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

AN79731620899-32-2AN 7973AN-7973ParasiteInhibitorinhibitorinhibit

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