Sp-5,6-DCl-cBIMPS
Sp-5,6-DCl-cBIMPS is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS stimulates insulin release. Sp-5,6-DCl-cBIMPS inhibits U-46619 (HY-108566)-induced activation of Rho, Gq and G12/G13 in platelets.
For research use only. We do not sell to patients.
- CAS No.: 120912-54-1
- Formula: C12H11Cl2N2O5PS
- Molecular Weight:397.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Sp-5,6-DCl-cBIMPS (0.005, 0.05, 0.5 mM; 60 min) stimulates insulin release from isolated pancreatic islets in a dose and time-dependent manner[2].
Sp-5,6-DCl-cBIMPS (0.005, 0.05, 0.5 mM; 60 min) increases glucose (8.5 mM)-stimulated insulin release[2].
Sp-5,6-DCl-cBIMPS (100 µM; 20 min) inhibits U-46619 (HY-108566)-induced Rho activation in wild-type mouse platelets, and inhibits U46619-induced activation of both Gq and G12/G13 in human platelets[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Wild-type mice, Human platelets
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Concentration:100 µM
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Incubation Time:20 min
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Result:Strongly suppressed U46619-induced Rho activation in wild-type, and inhibited U46619-induced activation of both Gq and G12/G13.
Chemical Information
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CAS No. 120912-54-1
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Molecular Weight 397.17
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Formula C12H11Cl2N2O5PS
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SMILES
O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@]2(S)=O)([H])N(C=NC3=C4)C3=CC(Cl)=C4Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sandberg M, et al. Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells. Biochem J. 1991 Oct 15;279 ( Pt 2)(Pt 2):521-7. [Content Brief]
[2]. Laychock SG. Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-cyclic monophosphorothioate is a potent stimulus for insulin release. Endocr Res. 1993;19(2-3):113-22. [Content Brief]
[3]. Gratacap MP, et al. Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Biol Chem. 2001 Dec 21;276(51):47906-13. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sp-5,6-DCl-cBIMPS Related Classifications
HY-137638 Related Classifications
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