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Cat. No.: HY-137638A

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Sp-5,6-DCl-cBIMPS sodium

(Synonyms: Sp-5,6-DCI-cBIMPS)

Sp-5,6-DCl-cBIMPS sodium is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS sodium stimulates insulin release. Sp-5,6-DCl-cBIMPS sodium inhibits U-46619 (HY-108566)-induced activation of Rho, Gq and G12/G13 in platelets.

For research use only. We do not sell to patients.

CAS No.: 142439-96-1
Formula: C₁₂H₁₀Cl₂N₂NaO₅PS
Molecular Weight:419.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Sp-5,6-DCl-cBIMPS sodium Chemical Structure

CAS No.: 142439-96-1

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Biological Activity

Description

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Chemical Information

CAS No. 142439-96-1
Molecular Weight 419.15
Formula C₁₂H₁₀Cl₂N₂NaO₅PS
SMILES

O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@]2(S[Na])=O)([H])N(C=NC3=C4)C3=CC(Cl)=C4Cl
Synonyms

Sp-5,6-DCI-cBIMPS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sandberg M, et al. Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells. Biochem J. 1991 Oct 15;279 ( Pt 2)(Pt 2):521-7. [Content Brief]

[2]. Laychock SG. Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-cyclic monophosphorothioate is a potent stimulus for insulin release. Endocr Res. 1993;19(2-3):113-22. [Content Brief]

[3]. Gratacap MP, et al. Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Biol Chem. 2001 Dec 21;276(51):47906-13. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Sp-5,6-DCl-cBIMPS sodium

All PKA Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Sp-5,6-DCl-cBIMPS sodium Related Classifications

HY-137638A Related Classifications