Rp-8-CPT-cAMPS sodium
Rp-8-CPT-cAMPS sodium, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS sodium preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI.
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- No. CAS: 221905-35-7
- Fòrmula: C16H14ClN5NaO5PS2
- Peso molecular:509.86
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Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-15979A
H-89 dihydrochloride -
HY-137640C
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HY-N6789
KT5720 -
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Rp-cAMPS sodium salt -
HY-18991
CCG215022 -
HY-100530
Rp-cAMPS triethylammonium salt -
HY-111759
Jaspamycin -
HY-15979
H-89 -
HY-112465
H-8 dihydrochloride -
HY-12306
8-Bromo-cAMP sodium salt -
HY-100983
Protein kinase inhibitor H-7 dihydrochloride -
HY-111673
8-CPT-Cyclic AMP sodium
Actividad biológica
Descripciòn
IC50 & Target
PKA[1]
In Vitro
Rp-8-CPT-cAMPS (100 μM; 15 min) blocks phosphorylation of VASP by 6-Bnz-cAMP and largely reduces VASP phosphorylation by forskolin and fenoterol[2].
Rp-8-CPT-cAMPS (100 μM; 30 min) reduces GTP-loading of Rap1 by both 8-pCPT-2'-O-Me-cAMP and 6-Bnz-cAMP[2].
Rp-8-CPT-cAMPS (100 μM; 30 min) largely diminishes the augmentation of bradykinin-induced IL-8 release by the PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2'-O-Me-cAMP[2].
Rp-8-CPT-cAMPS (10 μM) inhibits the endothelium-dependent and -independent relaxation which induced by Venom in pre-contracted rat mesenteric artery rings[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 221905-35-7
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Appearance Solid
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Peso molecular 509.86
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Fòrmula C16H14ClN5NaO5PS2
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Color White to off-white
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SMILES
O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@@]2([S-])=O)([H])N3C4=NC=NC(N)=C4N=C3SC(C=C5)=CC=C5Cl.[Na+]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
In Vitro:
DMF : 30 mg/mL (58.84 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (283 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Dostmann WR , et, al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91. [Content Brief]
[2]. Roscioni SS, et, al. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res. 2009 Sep 29;10(1):88. [Content Brief]
[3]. Chaisakul J, et, al. In vivo and in vitro cardiovascular effects of Papuan taipan (Oxyuranus scutellatus) venom: Exploring "sudden collapse". Toxicol Lett. 2012 Sep 3;213(2):243-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 1.9613 mL | 9.8066 mL | 19.6132 mL | 49.0331 mL |
| 5 mM | 0.3923 mL | 1.9613 mL | 3.9226 mL | 9.8066 mL | |
| 10 mM | 0.1961 mL | 0.9807 mL | 1.9613 mL | 4.9033 mL | |
| 15 mM | 0.1308 mL | 0.6538 mL | 1.3075 mL | 3.2689 mL | |
| 20 mM | 0.0981 mL | 0.4903 mL | 0.9807 mL | 2.4517 mL | |
| 25 mM | 0.0785 mL | 0.3923 mL | 0.7845 mL | 1.9613 mL | |
| 30 mM | 0.0654 mL | 0.3269 mL | 0.6538 mL | 1.6344 mL | |
| 40 mM | 0.0490 mL | 0.2452 mL | 0.4903 mL | 1.2258 mL | |
| 50 mM | 0.0392 mL | 0.1961 mL | 0.3923 mL | 0.9807 mL |
Rp-8-CPT-cAMPS sodium Related Classifications
HY-120994 Related Classifications
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