2. Stem Cell/Wnt TGF-beta/Smad
  3. PKA
  4. Rp-8-CPT-cAMPS sodium

Rp-8-CPT-cAMPS sodium, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS sodium preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI.

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Rp-8-CPT-cAMPS sodium Chemical Structure

Rp-8-CPT-cAMPS sodium Chemical Structure

CAS No. : 221905-35-7

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Other Forms of Rp-8-CPT-cAMPS sodium:

Rp-8-CPT-cAMPS sodium Related Antibodies

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Description

Rp-8-CPT-cAMPS sodium, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS sodium preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI[1][2].

IC50 & Target

PKA[1]
In Vitro

Rp-8-CPT-cAMPS (100 μM; 15 min) blocks phosphorylation of VASP by 6-Bnz-cAMP and largely reduces VASP phosphorylation by forskolin and fenoterol[2].
Rp-8-CPT-cAMPS (100 μM; 30 min) reduces GTP-loading of Rap1 by both 8-pCPT-2'-O-Me-cAMP and 6-Bnz-cAMP[2].
Rp-8-CPT-cAMPS (100 μM; 30 min) largely diminishes the augmentation of bradykinin-induced IL-8 release by the PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2'-O-Me-cAMP[2].
Rp-8-CPT-cAMPS (10 μM) inhibits the endothelium-dependent and -independent relaxation which induced by Venom in pre-contracted rat mesenteric artery rings[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rp-8-CPT-cAMPS sodium Related Antibodies
Molecular Weight

509.86

Formula

C16H14ClN5NaO5PS2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@@]2([S-])=O)([H])N3C4=NC=NC(N)=C4N=C3SC(C=C5)=CC=C5Cl.[Na+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMF : 30 mg/mL (58.84 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9613 mL 9.8066 mL 19.6132 mL
5 mM 0.3923 mL 1.9613 mL 3.9226 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 1.9613 mL 9.8066 mL 19.6132 mL 49.0331 mL
5 mM 0.3923 mL 1.9613 mL 3.9226 mL 9.8066 mL
10 mM 0.1961 mL 0.9807 mL 1.9613 mL 4.9033 mL
15 mM 0.1308 mL 0.6538 mL 1.3075 mL 3.2689 mL
20 mM 0.0981 mL 0.4903 mL 0.9807 mL 2.4517 mL
25 mM 0.0785 mL 0.3923 mL 0.7845 mL 1.9613 mL
30 mM 0.0654 mL 0.3269 mL 0.6538 mL 1.6344 mL
40 mM 0.0490 mL 0.2452 mL 0.4903 mL 1.2258 mL
50 mM 0.0392 mL 0.1961 mL 0.3923 mL 0.9807 mL
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Rp-8-CPT-cAMPS sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rp-8-CPT-cAMPS221905-35-7PKAProtein kinase AcAMPsiteABRIRIIInhibitorinhibitorinhibit

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