Rp-8-CPT-cAMPS
Rp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI.
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- CAS No.: 129735-01-9
- Formule: C16H15ClN5O5PS2
- Masse moléculaire:487.88
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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HY-B0764
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8-CPT-Cyclic AMP sodiumPKA Activator -
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6-Bnz-cAMP sodium saltPKA Activator -
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Cyclic GMP sodiumSecond Messenger -
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8-Chloro-cAMPcAMP Analogue -
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Bucladesine sodium (Standard)cAMP Analog -
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Rp-cAMPS triethylammonium saltPKA I/II Antagonist -
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8-pCPT-2'-O-Me-cAMP-AMAMP Analogue -
HY-B0764B
BucladesineCAMP Analog -
HY-B0764G
Bucladesine sodium (GMP)PKA activator
Activité biologique
Description
IC50 & Target
PKA[1]
In Vitro
Rp-8-CPT-cAMPS (100 μM; 15 min) blocks phosphorylation of VASP by 6-Bnz-cAMP and largely reduces VASP phosphorylation by forskolin and fenoterol[2].
Rp-8-CPT-cAMPS (100 μM; 30 min) reduces GTP-loading of Rap1 by both 8-pCPT-2'-O-Me-cAMP and 6-Bnz-cAMP[2].
Rp-8-CPT-cAMPS (100 μM; 30 min) largely diminishes the augmentation of bradykinin-induced IL-8 release by the PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2'-O-Me-cAMP[2].
Rp-8-CPT-cAMPS (10 μM) inhibits the endothelium-dependent and -independent relaxation which induced by Venom in pre-contracted rat mesenteric artery rings[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 129735-01-9
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Masse moléculaire 487.88
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Formule C16H15ClN5O5PS2
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SMILES
O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@@]2(S)=O)([H])N3C4=NC=NC(N)=C4N=C3SC(C=C5)=CC=C5Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Dostmann WR , et, al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91. [Content Brief]
[2]. Roscioni SS, et, al. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res. 2009 Sep 29;10(1):88. [Content Brief]
[3]. Chaisakul J, et, al. In vivo and in vitro cardiovascular effects of Papuan taipan (Oxyuranus scutellatus) venom: Exploring "sudden collapse". Toxicol Lett. 2012 Sep 3;213(2):243-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rp-8-CPT-cAMPS Related Classifications
HY-120994A Related Classifications
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