1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
  2. PKA
  3. Sp-8-CPT-cAMPS

Sp-8-CPT-cAMPS 

Cat. No.: HY-120994B
Handling Instructions

Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependent protein kinas A (PKA I and PKA II). Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold.

For research use only. We do not sell to patients.

Sp-8-CPT-cAMPS Chemical Structure

Sp-8-CPT-cAMPS Chemical Structure

CAS No. : 129693-13-6

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Description

Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependent protein kinas A (PKA I and PKA II). Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold[1][2].

IC50 & Target

PKA[1]

In Vitro

Sp-8-CPT-cAMPS (100 μM; 24 h) enhances the IL-1β-stimulated nitrite release, and increases the release ofnitrite by vascular smooth muscle cells by 3 fold in the absence of IL-1β in vascular smooth muscle cells[2].
Sp-8-CPT-cAMPS (100 μM; 24 h) increases IL-1β-induced expression of iNOS protein in rat aortic smooth muscle cells[2].
Sp-8-CPT-cAMPS (10 μM; 30 min) exhibits anti-spasmogenic activity on ACh-induced tension development in guinea-pig trachealis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

487.88

Formula

C₁₆H₁₅ClN₅O₅PS₂

CAS No.

129693-13-6

SMILES

O[[email protected]]1[[email protected]](O[[email protected]@](CO2)([H])[[email protected]@]1([H])O[[email protected]]2(S)=O)([H])N3C4=NC=NC(N)=C4N=C3SC(C=C5)=CC=C5Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Sp-8-CPT-cAMPSPKAProtein kinase AcAMP-dependentRIRIIsiteABInhibitorinhibitorinhibit

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Sp-8-CPT-cAMPS
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