Sp-8-CPT-cAMPS
Based on 1 publication(s) in Google Scholar
Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependent protein kinas A (PKA I and PKA II). Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold.
For research use only. We do not sell to patients.
- CAS No.: 129693-13-6
- Formula: C16H15ClN5O5PS2
- Molecular Weight:487.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Sp-8-CPT-cAMPS
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Biological Activity
PKA[1]
Sp-8-CPT-cAMPS (100 μM; 24 h) enhances the IL-1β-stimulated nitrite release, and increases the release ofnitrite by vascular smooth muscle cells by 3 fold in the absence of IL-1β in vascular smooth muscle cells[2].
Sp-8-CPT-cAMPS (100 μM; 24 h) increases IL-1β-induced expression of iNOS protein in rat aortic smooth muscle cells[2].
Sp-8-CPT-cAMPS (10 μM; 30 min) exhibits anti-spasmogenic activity on ACh-induced tension development in guinea-pig trachealis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 129693-13-6
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Molecular Weight 487.88
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Formula C16H15ClN5O5PS2
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SMILES
O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@]2(S)=O)([H])N3C4=NC=NC(N)=C4N=C3SC(C=C5)=CC=C5Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
[1]. Dostmann WR , et, al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91. [Content Brief]
[2]. Boese M, et, al. Effect of cyclic GMP-dependent vasodilators on the expression of inducible nitric oxide synthase in vascular smooth muscle cells: role of cyclic AMP. Br J Pharmacol. 1996 Oct;119(4):707-15. [Content Brief]
[3]. Spicuzza L, et, al. Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase. Br J Pharmacol. 2001 Aug;133(8):1201-12. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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