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Cat. No.: HY-153943

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DNA-PK-IN-10

DNA-PK-IN-10 is a DNA-PK inhibitor. DNA-PK-IN-10 can be used for the research of breast cancer and non-small cell lung cancer.

For research use only. We do not sell to patients.

CAS No.: 2919315-89-0
Formula: C₂₅H₂₈N₆O₂
Molecular Weight:444.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

DNA-PK-IN-10 Chemical Structure

CAS No.: 2919315-89-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

DNA-PK-IN-10 is a DNA-PK inhibitor. DNA-PK-IN-10 can be used for the research of breast cancer and non-small cell lung cancer^[1].

In Vitro

DNA-PK-IN-10 (Example 31) inhibits the viability of MDA-MB-468 cells, with an IC₅₀ of 11.2 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DNA-PK-IN-10 (Example 31) (30 mg/kg; administered twice a day) significantly inhibits tumor growth, and the shows good tolerance in mice were inoculated NCI-H1703 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2919315-89-0
Molecular Weight 444.53
Formula C₂₅H₂₈N₆O₂
SMILES

O=C(N1C)N(C2CCC(NCCOC3=CC=NC4=C5)CC2)C(C1=CN6)=CC6=NC(C=C43)=C5C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kuncheng C, et, al. Dna-pk selective inhibitor, and preparation method therefor and use thereof. WO2023036156A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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