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Cat. No.: HY-145261

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hDHODH-IN-8

hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC₅₀ of 16 nM. hDHODH-IN-8 has potent antiproliferative activity and excellent aqueous solubility. hDHODH-IN-8 has the potential for the research of tumor disease, especially lymphoma.

For research use only. We do not sell to patients.

CAS No.: 2757405-31-3
Formula: C₂₁H₁₅F₆N₃O₄
Molecular Weight:487.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

hDHODH-IN-8 Chemical Structure

CAS No.: 2757405-31-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Daudi	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human Daudi cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human Daudi cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
HEL	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human HEL cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human HEL cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
HL-60	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
L02	IC₅₀	517.8 nM Compound: 13t	Cytotoxicity against human L02 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Cytotoxicity against human L02 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
MV4-11	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
Raji	IC₅₀	7.7 nM Compound: 13t	Antiproliferative activity against human Raji cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human Raji cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
SUD4	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
SU-DHL-6	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
THP-1	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human THP-1 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human THP-1 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]

Chemical Information

CAS No. 2757405-31-3
Molecular Weight 487.35
Formula C₂₁H₁₅F₆N₃O₄
SMILES

FC1=C(NC(/C(C#N)=C(O)/C)=O)C=C(O[C@H](C(F)(F)F)C)C(C(NC2=C(F)C=CC=C2F)=O)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li C, et al. Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment. J Med Chem. 2021;64(24):18175-18192. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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