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Art. -Nr.: HY-145261

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hDHODH-IN-8

hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC₅₀ of 16 nM. hDHODH-IN-8 has potent antiproliferative activity and excellent aqueous solubility. hDHODH-IN-8 has the potential for the research of tumor disease, especially lymphoma.

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CAS. Nr.: 2757405-31-3
Formel: C₂₁H₁₅F₆N₃O₄
Molecular Weight:487.35

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

hDHODH-IN-8 Chemical Structure

CAS. Nr.: 2757405-31-3

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Protokoll (2)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
Daudi	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human Daudi cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human Daudi cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
HEL	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human HEL cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human HEL cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
HL-60	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
L02	IC₅₀	517.8 nM Compound: 13t	Cytotoxicity against human L02 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Cytotoxicity against human L02 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
MV4-11	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
Raji	IC₅₀	7.7 nM Compound: 13t	Antiproliferative activity against human Raji cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human Raji cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
SUD4	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
SU-DHL-6	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]
THP-1	IC₅₀	20 nM Compound: 13t	Antiproliferative activity against human THP-1 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay Antiproliferative activity against human THP-1 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay	[PMID: 34905371]

Chemical Information

CAS. Nr. 2757405-31-3
Molecular Weight 487.35
Formel C₂₁H₁₅F₆N₃O₄
SMILES

FC1=C(NC(/C(C#N)=C(O)/C)=O)C=C(O[C@H](C(F)(F)F)C)C(C(NC2=C(F)C=CC=C2F)=O)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li C, et al. Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment. J Med Chem. 2021;64(24):18175-18192. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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