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  4. PDLLA3000-mPEG2000, PDI≤1.25

PDLLA3000-mPEG2000, PDI≤1.25 is an amphiphilic block copolymer composed of methoxy poly(ethylene glycol) and poly(D,L-lactide). PDLLA3000-mPEG2000, PDI≤1.25 functions as a self-assembled polymeric micelle component to enhance aqueous solubility and oral bioavailability in bioactive substances. PDLLA3000-mPEG2000, PDI≤1.25 can be used in the study of drug delivery.

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PDLLA3000-mPEG2000, PDI≤1.25

PDLLA3000-mPEG2000, PDI≤1.25 Chemical Structure

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PDLLA3000-mPEG2000, PDI≤1.25 Related Antibodies

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Description

PDLLA3000-mPEG2000, PDI≤1.25 is an amphiphilic block copolymer composed of methoxy poly(ethylene glycol) and poly(D,L-lactide). PDLLA3000-mPEG2000, PDI≤1.25 functions as a self-assembled polymeric micelle component to enhance aqueous solubility and oral bioavailability in bioactive substances. PDLLA3000-mPEG2000, PDI≤1.25 can be used in the study of drug delivery[1][2].

In Vitro

PDLLA3000-mPEG2000, PDI≤1.25, combined with d-α-tocopherol acid of polyethylene glycol succinat (TPGs), forms a homogeneous, stable spherical micellar system with a particle size of 67.42 nm, PDI of 0.229, and zeta potential of -18.67 mV when used to fabricate Hyperoside (HY-N0452)-loaded micelles via thin film dispersion[1].
PDLLA3000-mPEG2000, PDI≤1.25 (0.1-10 μg/mL; 12 h dark incubation), combined with TPGs, forms blank micelles with a critical micelle concentration of 2.56 μg/mL, indicating excellent self-assembly capability and stability[1].
PDLLA3000-mPEG2000, PDI≤1.25 (10-200 μg/mL; 48 h), combined with TPGs, forms blank micelles that exhibit low cytotoxicity[1].
PDLLA3000-mPEG2000, PDI≤1.25 forms stable spherical nanomicelles with glucose-Paclitaxel (HY-B0015), achieving a high encapsulation efficiency of 95.59% and drug loading of 11.46%, with no significant changes in size or zeta potential over 28 days of storage at 25°C or 4°C[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PDLLA3000-mPEG2000, PDI≤1.25 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Human foreskin fibroblast (HFF) cells
Concentration: 10 μg/mL; 25 μg/mL; 50 μg/mL; 100 μg/mL; 200 μg/mL
Incubation Time: 48 h
Result: Maintained HFF cell viability above 80% at all tested concentrations, indicating low cytotoxicity and good biocompatibility.
In Vivo

PDLLA3000-mPEG2000, PDI≤1.25 (2.5 mg/mL; i.g.; single dose), as part of Hyperoside-loaded polymeric micelles, increases the oral bioavailability of Hyperoside by 8-fold and extends its half-life by 3-fold in healthy male Sprague Dawley rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (male, 200 g)[1]
Dosage: 2.5 mg/mL
Administration: i.g.; single dose
Result: Achieved an 8-fold increase in oral bioavailability (AUC0-t = 16.08 μg·h/mL vs. 2.07 μg·h/mL for free hyperoside).
Extended half-life by 3-fold (t1/2 = 28.70 h vs. 9.43 h for free hyperoside).
Increased maximum plasma concentration (Cmax = 1.11 μg/mL vs. 0.71 μg/mL for free hyperoside).
Delayed time to maximum concentration (Tmax = 4 h vs. 3 h for free hyperoside).
Extended mean residence time (MRT0-t = 13.23 h vs. 3.31 h for free hyperoside).
SMILES

COCCOC(C(OC(C(C)O)=O)C)=O.[n].[m]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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PDLLA3000-mPEG2000, PDI≤1.25 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDLLA3000-mPEG2000, PDI≤1.25Biochemical Assay Reagentspoly(D,L-lactide)nanomicelleamphiphilic block copolymermethoxy poly(ethylene glycol)polymeric micelleHFF cellrat plasmaglucose-paclitaxel conjugateSprague Dawley ratshyperosideInhibitorinhibitorinhibit

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