PDLLA3000-mPEG2000, PDI≤1.25
Based on 1 Customer Validation
PDLLA3000-mPEG2000, PDI≤1.25 is an amphiphilic block copolymer composed of methoxy poly(ethylene glycol) and poly(D,L-lactide). PDLLA3000-mPEG2000, PDI≤1.25 functions as a self-assembled polymeric micelle component to enhance aqueous solubility and oral bioavailability in bioactive substances. PDLLA3000-mPEG2000, PDI≤1.25 can be used in the study of drug delivery.
For research use only. We do not sell to patients.
- Purity : 95.0%
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
Description
In Vitro
PDLLA3000-mPEG2000, PDI≤1.25, combined with d-α-tocopherol acid of polyethylene glycol succinat (TPGs), forms a homogeneous, stable spherical micellar system with a particle size of 67.42 nm, PDI of 0.229, and zeta potential of -18.67 mV when used to fabricate Hyperoside (HY-N0452)-loaded micelles via thin film dispersion[1].
PDLLA3000-mPEG2000, PDI≤1.25 (0.1-10 μg/mL; 12 h dark incubation), combined with TPGs, forms blank micelles with a critical micelle concentration of 2.56 μg/mL, indicating excellent self-assembly capability and stability[1].
PDLLA3000-mPEG2000, PDI≤1.25 (10-200 μg/mL; 48 h), combined with TPGs, forms blank micelles that exhibit low cytotoxicity[1].
PDLLA3000-mPEG2000, PDI≤1.25 forms stable spherical nanomicelles with glucose-Paclitaxel (HY-B0015), achieving a high encapsulation efficiency of 95.59% and drug loading of 11.46%, with no significant changes in size or zeta potential over 28 days of storage at 25°C or 4°C[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:Human foreskin fibroblast (HFF) cells
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Concentration:10 μg/mL; 25 μg/mL; 50 μg/mL; 100 μg/mL; 200 μg/mL
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Incubation Time:48 h
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Result:Maintained HFF cell viability above 80% at all tested concentrations, indicating low cytotoxicity and good biocompatibility.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley (male, 200 g)[1]
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Dosage:2.5 mg/mL
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Administration:i.g.; single dose
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Result:Achieved an 8-fold increase in oral bioavailability (AUC0-t = 16.08 μg·h/mL vs. 2.07 μg·h/mL for free hyperoside).
Extended half-life by 3-fold (t1/2 = 28.70 h vs. 9.43 h for free hyperoside).
Increased maximum plasma concentration (Cmax = 1.11 μg/mL vs. 0.71 μg/mL for free hyperoside).
Delayed time to maximum concentration (Tmax = 4 h vs. 3 h for free hyperoside).
Extended mean residence time (MRT0-t = 13.23 h vs. 3.31 h for free hyperoside).
Chemical Information
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Appearance Solid
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Color White to off-white
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SMILES
COCCOC(C(OC(C(C)O)=O)C)=O.[n].[m]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Protocols
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Protocol for Pharmacokinetic Study
Pharmacokinetic studies quantify how an organism handles a drug over time through absorption, distribution, metabolism, and excretion, and the core experimental readout is the concentration-time profile of parent drug and, when relevant, metabolites in biological matrices such as plasma, whole blood, urine, bile, or tissue. Pharmacokinetic analysis links dose, route, exposure, clearance, half-life, distribution, bioavailability, and systemic exposure to drug efficacy and toxicity hypotheses rather than measuring a signaling pathway directly. The literature links pharmacokinetics to drug-development phenotypes by showing that drug metabolism and pharmacokinetics influence compound progression, exposure-response interpretation, safety margins, dosing strategy, and failure risk during discovery and development. DMPK science contributes to compound optimization by integrating physicochemical properties, in vitro metabolism, transporter behavior, in vivo exposure, and pharmacodynamic contex
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Xia X, et al. Hyperoside-loaded TPGs/mPEG-PDLLA self-assembled polymeric micelles: preparation, characterization and in vitro/in vivo evaluation. Pharm Dev Technol. 2022 Sep;27(7):829-841. [Content Brief]
[2]. Yan D, et al. Nanomicellar Prodrug Delivery of Glucose-Paclitaxel: A Strategy to Mitigate Paclitaxel Toxicity. Int J Nanomedicine. 2025;20:2087-2101. Published 2025 Feb 17. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)