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collagen II α1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Collagen (2) Apoptosis (1) Liposome (4)
By Research Areas:	Inflammation/Immunology (5)
Oligonucleotides:	Pegylated Lipids (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Collagen Photosystem II CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-172696

DSPE-PEG2000-WYRGRL	Liposome Collagen	Inflammation/Immunology
DSPE-PEG2000-WYRGRL is a PEG compound which composed of DSPE and a cartilage-targeting peptide (WYRGRL). WYRGRL is a collagen II-targeting peptide that can bind to collagen II α1. DSPE-PEG2000-WYRGRL can be used for drug delivery ^[1].

HY-172696A

DSPE-PEG3400-WYRGRL	Liposome	Inflammation/Immunology
DSPE-PEG3400-WYRGRL is a PEG compound which composed of DSPE and a cartilage-targeting peptide (WYRGRL). WYRGRL is a collagen II-targeting peptide that can bind to collagen II α1. DSPE-PEG3400-WYRGRL can be used for drug delivery ^[1].

HY-172697

DSPE-PEG5000-WYRGRL	Liposome	Inflammation/Immunology
DSPE-PEG5000-WYRGRL is a PEG compound which composed of DSPE and a cartilage-targeting peptide (WYRGRL). WYRGRL is a collagen II-targeting peptide that can bind to collagen II α1. DSPE-PEG5000-WYRGRL can be used for drug delivery ^[1].

HY-P10739C

WYRGRLC	Collagen Apoptosis	Inflammation/Immunology
WYRGRLC is a type II collagen-targeting peptide. WYRGRLC specifically binds to type II collagen α1 in articular cartilage in a sequence-dependent manner. WYRGRLC inhibits the binding of WYRGRL-displaying phage (C1-3) to articular cartilage in a sequence-specific manner. WYRGRLC can act as a retention enhancer to improve the cartilage-targeting ability of polymeric nanoparticles and liposomal nanoplatforms, facilitating the delivery of Rapamycin (HY-10219) to chondrocytes. WYRGRLC can be used in studies related to osteoarthritis ^[1] .

HY-172695

DSPE-PEG1000-WYRGRL	Liposome	Inflammation/Immunology
DSPE-PEG1000-WYRGRL is a PEG compound which composed of DSPE and a cartilage-targeting peptide (WYRGRL). WYRGRL is a collagen II-targeting peptide that can bind to collagen II α1. DSPE-PEG1000-WYRGRL can be used for drug delivery ^[1].

Cat. No.	Product Name	Type

HY-172696

DSPE-PEG2000-WYRGRL	Biochemical Assay Reagents
DSPE-PEG2000-WYRGRL is a PEG compound which composed of DSPE and a cartilage-targeting peptide (WYRGRL). WYRGRL is a collagen II-targeting peptide that can bind to collagen II α1. DSPE-PEG2000-WYRGRL can be used for drug delivery ^[1].

HY-172696A

DSPE-PEG3400-WYRGRL	Biochemical Assay Reagents
DSPE-PEG3400-WYRGRL is a PEG compound which composed of DSPE and a cartilage-targeting peptide (WYRGRL). WYRGRL is a collagen II-targeting peptide that can bind to collagen II α1. DSPE-PEG3400-WYRGRL can be used for drug delivery ^[1].

HY-172697

DSPE-PEG5000-WYRGRL	Biochemical Assay Reagents
DSPE-PEG5000-WYRGRL is a PEG compound which composed of DSPE and a cartilage-targeting peptide (WYRGRL). WYRGRL is a collagen II-targeting peptide that can bind to collagen II α1. DSPE-PEG5000-WYRGRL can be used for drug delivery ^[1].

HY-172695

DSPE-PEG1000-WYRGRL	Biochemical Assay Reagents
DSPE-PEG1000-WYRGRL is a PEG compound which composed of DSPE and a cartilage-targeting peptide (WYRGRL). WYRGRL is a collagen II-targeting peptide that can bind to collagen II α1. DSPE-PEG1000-WYRGRL can be used for drug delivery ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P10739C

WYRGRLC	Collagen Apoptosis	Inflammation/Immunology
WYRGRLC is a type II collagen-targeting peptide. WYRGRLC specifically binds to type II collagen α1 in articular cartilage in a sequence-dependent manner. WYRGRLC inhibits the binding of WYRGRL-displaying phage (C1-3) to articular cartilage in a sequence-specific manner. WYRGRLC can act as a retention enhancer to improve the cartilage-targeting ability of polymeric nanoparticles and liposomal nanoplatforms, facilitating the delivery of Rapamycin (HY-10219) to chondrocytes. WYRGRLC can be used in studies related to osteoarthritis ^[1] .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75333

	Collagen alpha-1(II) chain/COL2A1 Protein, Human (HEK293, His) collagen alpha-1(II) chain; Chondrocalcin; COL2A1	Human	HEK293
	COL2A1, encoding the alpha-1(II) chain of type II collagen, is specific to cartilaginous tissues, essential for embryonic skeletal development, linear growth, and cartilage resilience against compressive forces. As a fundamental component of homotrimers, COL2A1 maintains the structural integrity and function of cartilage, crucial for skeletal form and function during development and in resisting mechanical stress. Collagen alpha-1 (II) chain/COL2A1 Protein, Human (HEK293, His) is the recombinant human-derived Collagen alpha-1(II) chain/COL2A1 protein, expressed by HEK293 , with N-His labeled tag.

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Host:	Rabbit (3)
Reactivity:	Human (3) Rat (1) Mouse (1)
Application:	IHC-P (3) ICC/IF (1) IF-Tissue (2) IP (1) WB (3) ELISA (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Polyclonal (1) Monoclonal (2) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81047

	Collagen II Antibody 1 Publications Verification collagen II alpha 1; COL2A1; COL2A1 protein; collagen, type II, alpha 1; collagen alpha-1(II); type II collagen; alpha-1 type II collagen; alpha1 type II collagen; Col2a1; AOM; Cartilage collagen; Chondrocalcin; COL11A3; collagen alpha 1(II) chain precursor; collagen II alpha 1 polypeptide; collagen type II alpha 1 (primary osteoarthritis spondyloepiphyseal dysplasia congenital); MGC131516; SEDC; collagen alpha-1(II) chain; Alpha-1 type II collagen; CO2A1_HUMAN.; collagenII;	WB, IHC-P, IF-Tissue	Human
	Collagen II Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Collagen II.

HY-P81047A

	Collagen II Antibody(YA3550) 1 Publications Verification collagen II alpha 1; COL2A1; COL2A1 protein; collagen, type II, alpha 1; collagen alpha-1(II); type II collagen; alpha-1 type II collagen; alpha1 type II collagen; Col2a1; AOM; Cartilage collagen; Chondrocalcin; COL11A3; collagen alpha 1(II) chain precursor; collagen II alpha 1 polypeptide; collagen type II alpha 1 (primary osteoarthritis spondyloepiphyseal dysplasia congenital); MGC131516; SEDC; collagen alpha-1(II) chain; Alpha-1 type II collagen; CO2A1_HUMAN.; collagenII;	WB, IHC-P, IF-Tissue	Human, Mouse, Rat
	Collagen II Antibody(YA3550) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Collagen II.

HY-P86154

	Collagen II Antibody (YA5846) collagen alpha-1; II; chain; Alpha-1 type II collagen; [Cleaved into: collagen alpha-1; II; chain; Chondrocalcin]	WB, IHC-P, ICC/IF, IP, ELISA	Human
	Collagen II Antibody (YA5846) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Collagen II.

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Cat. No.	Product Name		Classification

HY-172696

DSPE-PEG2000-WYRGRL		Pegylated Lipids
DSPE-PEG2000-WYRGRL is a PEG compound which composed of DSPE and a cartilage-targeting peptide (WYRGRL). WYRGRL is a collagen II-targeting peptide that can bind to collagen II α1. DSPE-PEG2000-WYRGRL can be used for drug delivery ^[1].

HY-172696A

DSPE-PEG3400-WYRGRL		Pegylated Lipids
DSPE-PEG3400-WYRGRL is a PEG compound which composed of DSPE and a cartilage-targeting peptide (WYRGRL). WYRGRL is a collagen II-targeting peptide that can bind to collagen II α1. DSPE-PEG3400-WYRGRL can be used for drug delivery ^[1].

HY-172697

DSPE-PEG5000-WYRGRL		Pegylated Lipids
DSPE-PEG5000-WYRGRL is a PEG compound which composed of DSPE and a cartilage-targeting peptide (WYRGRL). WYRGRL is a collagen II-targeting peptide that can bind to collagen II α1. DSPE-PEG5000-WYRGRL can be used for drug delivery ^[1].

HY-172695

DSPE-PEG1000-WYRGRL		Pegylated Lipids
DSPE-PEG1000-WYRGRL is a PEG compound which composed of DSPE and a cartilage-targeting peptide (WYRGRL). WYRGRL is a collagen II-targeting peptide that can bind to collagen II α1. DSPE-PEG1000-WYRGRL can be used for drug delivery ^[1].

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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