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cyclin+A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CDK (6) Apoptosis (1) Autophagy (1) Bcl-2 Family (1) Caspase (1) Cholinesterase (ChE) (1) Ferroptosis (1) IFNAR (1) Interleukin Related (1) MDM-2/p53 (1) Mitochondrial Metabolism (1) Mitophagy (1) MMP (1) PARP (1) PI3K (1) PROTACs (1) Reactive Oxygen Species (ROS) (2)
By Research Areas:	Cancer (8) Infection (1) Inflammation/Immunology (2)

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Natural
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Recombinant Proteins

Antibodies

Targets Recommended: CDK Cyclin G-associated Kinase (GAK) CDKL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15569

NU6102	CDK	Cancer
NU6102 is a potent CDK1 and CDK2 inhibitor with IC₅₀s of 9.5 nM and 5.4 nM for CDK1/cyclinB and *CDK2/cyclinA3, respectively. NU6102 shows selectivity for CDK1/CDK2* over CDK4 (IC₅₀ of 1.6 μM), DYRK1A (IC₅₀ of 0.9 μM), PDK1 (IC₅₀ of 0.8 μM) and ROCKII (IC₅₀ of 0.6 μM) .

HY-N4087

Platycodin D2 3 Publications Verification	Mitophagy Autophagy Ferroptosis Interleukin Related IFNAR Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum. Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the *P21/CyclinA2* pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy, inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ, and Th2 cytokines IL-4 and IL-10, enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS production, incomplete autophagy, and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer, inflammation and immunology .

HY-119979

Cardanol monoene Cardanol C15:1	Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism MMP CDK Caspase Bcl-2 Family PARP MDM-2/p53 Cholinesterase (ChE)	Infection Inflammation/Immunology Cancer
Cardanol monoene (Cardanol C15:1) is a phenolic compound which can be found in cashew nut shell liquid. Cardanol monoene can inhibit cancer cells proliferation, migration, cause S phase arrest, induce apoptosis, ROS production and mitochondrial depolarization. Cardanol monoene downregulates MMP-2, MMP-9, *cyclinA1* expression, regulates CDK2, p53, Bax, cytochrome c, cleaved caspase-3, cleaved PARP, Apaf-1 expression and Bax/Bcl-2 ratio. Cardanol monoene shows weak DPPH radical scavenging activity and AChE inhibition activity. Cardanol monoene is lethal to Artemia salina nauplii. Cardanol monoene. Cardanol monoene can be used for the research of cancer, infection and inflamation .

HY-175729

Cyclin A/B RxL-IN-1	CDK	Cancer
Cyclin A/B RxL-IN-1 is a inhibitor targeting the Cyclin A/B RxL interaction at the hydrophobic patch (HP). Cyclin A/B RxL-IN-1 inhibits Cyclin A with an IC₅₀ of 0.12 μM. Cyclin A/B RxL-IN-1 demonstrates antitumor efficacy in mouse cell line-derived xenograft (CDX) models. CDK-IN-19 can be used for the study of E2F-driven cancers such as small-cell lung cancer (SCLC) .

HY-164906

TMX-2138	CDK PROTACs	Cancer
TMX-2138 is a CDKs PROTAC degrader, with IC₅₀s of 8.7 nM, 10.9 nM, 7.0 nM and 25.7 nM for CDK1/cyclinB, CDK2/cyclinA, CDK5/p25 and CDK9/cyclinT1, respectively. TMX-2138 promotes ubiquitination and degradation of CDKs. TMX-2138 can be used for the research of ovarian cancer (Pink: CDKs ligand (HY-151071); Blue: E3 ligase CRBN ligand (HY-14658); Black: linker (HY-W008352)) .

HY-151375

CDK9/10/GSK3β-IN-1	CDK	Cancer
CDK9/10/GSK3β-IN-1 (compound 13c) is a kinase inhibitor (Flavopiridol (HY-10005) analogue) that effectively inhibits HsGSK3β (IC₅₀=59 nM), HsCDK9/CyclinT (IC₅₀=64 nM), HsCDK5/p25 (IC₅₀=1.093 μM) and *HsCDK2/CyclinA* (IC₅₀=1.725 μM). CDK9/10/GSK3β-IN-1 has anti-cancer cellular activity comparable to or higher than that of Flavopiridol. CDK9/10/GSK3β-IN-1 shows high anti-proliferative activity in vitro against up to seven cancer cell lines .

HY-155180

FD2056	PI3K	Cancer
FD2056 is a potent and orally active PI3K inhibitor. FD2056 inhibits PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ with IC₅₀s of 0.30, 0.80, 1.10, 0.42 nM. FD2056 also inhibits CDK2-CyclinA2 and CDK4-CyclinD3 with IC₅₀ of 115.95 and 2782.15 nM. FD2056 inhibits breast cancer cell proliferation with IC₅₀s of 1.06, 0.04, 1.40 μM for MDA-MB-231, MDA-MB-468, MCF-7 cells. FD2056 also induces cancer apoptosis and inhibits tumor growth .

HY-123238

AG-024104	CDK	Cancer
AG-024104 is a CDK inhibitor with K_i values of 2.3 nM (CDK1/cyclinB), 1.8 nM (CDK2/cyclinA), and 0.67 nM (CDK4/cyclinD). AG-024104 functionally inhibits kinase activity of CDK1/cyclinB, *CDK2*/cyclinA, and CDK4/cyclinD. AG-024104 serves as a negative control for peripheral leukocyte toxicity studies in preclinical development .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4087

Platycodin D2 3 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Source Classification Cancer	Mitophagy Autophagy Ferroptosis Interleukin Related IFNAR Reactive Oxygen Species (ROS)
Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum. Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the *P21/CyclinA2* pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy, inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ, and Th2 cytokines IL-4 and IL-10, enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS production, incomplete autophagy, and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer, inflammation and immunology .

HY-119979

Cardanol monoene Cardanol C15:1	Monophenols Classification of Application Fields Phenols Plants Anacardium occidentaleL. Disease Research Fields Anacardiaceae Source Classification Cancer	Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism MMP CDK Caspase Bcl-2 Family PARP MDM-2/p53 Cholinesterase (ChE)
Cardanol monoene (Cardanol C15:1) is a phenolic compound which can be found in cashew nut shell liquid. Cardanol monoene can inhibit cancer cells proliferation, migration, cause S phase arrest, induce apoptosis, ROS production and mitochondrial depolarization. Cardanol monoene downregulates MMP-2, MMP-9, *cyclinA1* expression, regulates CDK2, p53, Bax, cytochrome c, cleaved caspase-3, cleaved PARP, Apaf-1 expression and Bax/Bcl-2 ratio. Cardanol monoene shows weak DPPH radical scavenging activity and AChE inhibition activity. Cardanol monoene is lethal to Artemia salina nauplii. Cardanol monoene. Cardanol monoene can be used for the research of cancer, infection and inflamation .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72962

	Cyclin A1 Protein, Human (sf9, His) CCNA1; Cyclin A1; cyclin-A1	Human	Sf9 insect cells
	Cyclin A1 protein is a key regulator in the cell cycle, affecting G1/S and G2/M transitions and playing a major role in the germline meiotic cell cycle. It interacts with CDK2 and CDC2 kinase to form a holoenzyme complex that participates in the regulatory pathways of E2F-1 and RB proteins. Cyclin A1 Protein, Human (sf9, His) is the recombinant human-derived Cyclin A1 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P703551

	CCNA2 Protein, Human CCN1; CCNA; Cyclin-A2	Human	E. coli
	CCNA2 Protein, Human is the recombinant human-derived CCNA2 protein, expressed by E. coli, with tag free tag.

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Host:	Mouse (3) Rabbit (8)
Reactivity:	Human (10) Rat (7) Mouse (7) Monkey (1)
Application:	IHC-P (7) ICC/IF (6) IP (3) IHC-F (1) WB (11) FC (3) ELISA (4)
Isotype:	IgG (8) IgG1 (3)
Conjugation:	Non-conjugated (11)
Clonality:	Polyclonal (1) Monoclonal (6) Monoclonal Antibody (1) Recombinant (4)
Modification:	Unmodified (8)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83591

	Cyclin A2 Antibody (YA3336) CCN1; CCNA; CCNA1; CCNA2; CT146; Cyclin-A; Cyclin-A1; Cyclin-A2	WB, IP	Human
	Cyclin A2 Antibody (YA3336) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclin A2.

HY-P83591A

	Cyclin A2 Antibody (YA3336)(PBS only) CCN1; CCNA; CCNA1; CCNA2; CT146; Cyclin-A; Cyclin-A1; Cyclin-A2	WB, IP	Human
	Cyclin A2 Antibody (YA3336) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclin A2.

HY-P80096

	Cyclin A2 Antibody (YA487)	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Cyclin A2 Antibody (YA487) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclin A2.

HY-P80631

	Cyclin A1 Antibody 1 Publications Verification CCNA1; Cyclin-A1	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat, Monkey
	Cyclin A1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Cyclin A1.

HY-P86489

	Cyclin A2 Antibody (YA6181)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Cyclin A2 Antibody (YA6181) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclin A2.

HY-P84166

	Cyclin A2 Antibody (YA3863) CCN1; CCNA	WB, IHC-P, FC, ELISA	Human
	Cyclin A2 Antibody (YA3863) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cyclin A2.

HY-P84166A

	Cyclin A2 Antibody (YA3863)(PBS only) CCN1; CCNA	WB, IHC-P, FC, ELISA	Human
	Cyclin A2 Antibody (YA3863) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cyclin A2.

HY-P81587

	SKP2 Antibody (YA1332) SKP2; FBXL1; S-phase kinase-associated protein 2; Cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; p45skp2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	SKP2 Antibody (YA1332) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SKP2.

HY-P85367

	SKP2 Antibody (YA5059) SKP2; FBXL1; S-phase kinase-associated protein 2; Cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; p45skp2	WB, IHC-P	Mouse, Rat
	SKP2 Antibody (YA5059) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SKP2.

HY-P82229

	SKP1 Antibody (YA1974) SKP1; EMC19; OCP2; SKP1A; TCEB1L; S-phase kinase-associated protein 1; Cyclin-A/CDK2-associated protein p19; Organ of Corti protein 2; OCP-2; Organ of Corti protein II; OCP-II; RNA polymerase II elongation factor-like protein; SIII; Transcr	WB, ICC/IF	Human, Mouse, Rat
	SKP1 Antibody (YA1974) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SKP1.

HY-P82229A

	SKP1 Antibody (YA1974)(PBS only) SKP1; EMC19; OCP2; SKP1A; TCEB1L; S-phase kinase-associated protein 1; Cyclin-A/CDK2-associated protein p19; Organ of Corti protein 2; OCP-2; Organ of Corti protein II; OCP-II; RNA polymerase II elongation factor-like protein; SIII; Transcr	WB, ICC/IF	Human, Mouse, Rat
	SKP1 Antibody (YA1974) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SKP1.

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cyclin+A

Inhibitors & Agonists

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