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dengue virus envelope protein

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By Targets:	Dengue Virus (6) Bacterial (2) Flavivirus (2) Fungal (1) Histamine Receptor (1) HIV (1) PROTACs (1) SARS-CoV (1)
By Research Areas:	Cancer (1) Infection (6) Inflammation/Immunology (1) Neurological Disease (1)

6

Inhibitors & Agonists

1

Peptides

1

Inhibitory Antibodies

1

Natural
Products

9

Recombinant Proteins

Targets Recommended: Dengue Virus

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Nimbin	Flavivirus Dengue Virus Fungal Bacterial Histamine Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the **envelope protein of dengue virus**. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin is promising for research of neurodegenerative diseases and viral infections .

Anti-West Nile/dengue virus E protein Antibody (E60)	Dengue Virus Flavivirus	Infection
Anti-West Nile/dengue virus E protein Antibody (E60) is mouse-derived IgG2a κ type antibody inhibitor, targeting to West Nile/dengue virus E protein. Anti-West Nile/dengue virus E protein Antibody (E60) can cross-neutralize West Nile virus (WNV) and dengue virus (DENV) envelope (E) protein. Anti-West Nile/dengue virus E protein Antibody (E60) can be used for the researches of WNV and DENV infection .

ZK-806450	SARS-CoV Dengue Virus	Infection
ZK-806450 is a compound with antiviral activity. ZK-806450 has a high binding potential to the allosteric binding site of the SARS-CoV-2 3CL protease. ZK-806450 can also specifically and stably bind to the GAG site of the **dengue virus envelope protein** .

GNF-2-deg	PROTACs Dengue Virus	Infection
GNF-2-deg is a PROTAC degrader for dengue virus envelope protein (DENV E protein) with DC₅₀ of 0.83 μM. GNF-2-deg prevents viral entry by inhibiting E-mediated membrane fusion, prevents virion production by protein degradation, and thereby exhibits antiviral activity against DENV 2 with EC₉₀ of 3.5 μM. GNF-2-deg exhibits antiviral activity against ZIKV, JEV, WNV and YFV with EC₉₀ of 1.96-7.79 μM. (Pink: ligand for target protein (HY-161805); Black: linker (HY-42149); Blue: ligand for E3 ligase (HY-23095))

MLH40	Dengue Virus	Infection
MLH40 is a peptide inhibitor with activity against Dengue virus (DENV) infection, which is found in the conserved ectodomain region of DENV membrane protein. MLH40 inhibits DENV through its N-terminal loop interaction with DENV envelope protein and altering the dimer conformation .

Circulin B	Bacterial HIV Dengue Virus	Infection
Circulin B is a macrocyclic plant cyclopeptide. Circulin B functions as a plant defense peptide and exhibits antibacterial and anti-HIV activities. Circulin B has high binding affinity for the envelope protein of dengue virus, showing potential anti-dengue virus activity. Circulin B can be used in studies related to dengue virus infection, human immunodeficiency virus infection and microbial infection .

Cat. No.	Product Name	Target	Research Area

MLH40	Dengue Virus	Infection
MLH40 is a peptide inhibitor with activity against Dengue virus (DENV) infection, which is found in the conserved ectodomain region of DENV membrane protein. MLH40 inhibits DENV through its N-terminal loop interaction with DENV envelope protein and altering the dimer conformation .

Cat. No.	Product Name	Target	Research Area	Image

Anti-West Nile/dengue virus E protein Antibody (E60)	Dengue Virus Flavivirus	Infection
Anti-West Nile/dengue virus E protein Antibody (E60) is mouse-derived IgG2a κ type antibody inhibitor, targeting to West Nile/dengue virus E protein. Anti-West Nile/dengue virus E protein Antibody (E60) can cross-neutralize West Nile virus (WNV) and dengue virus (DENV) envelope (E) protein. Anti-West Nile/dengue virus E protein Antibody (E60) can be used for the researches of WNV and DENV infection .

Species:	Virus (9)
Tag:	His (9)
Source:	HEK293 (3) P. pastoris (2) Sf9 insect cells (4)

Cat. No.	Compare	Product Name	Species	Source	Image

	*E/Envelope* Protein, Dengue virus 1 (101a.a, sf9, His)** E protein; DENV; envelope; dengue virus (DENV) (type 1, strain US/Hawaii/1944) E/envelope protein Domain III	Virus	Sf9 insect cells
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles.During entry, NS1 induces genome penetration into the host cytoplasm.E/Envelope Protein, Dengue virus 1 (101a.a, sf9, His) is the recombinant Virus-derived E/Envelope protein, expressed by Sf9 insect cells , with C-His labeled tag.

	*E/Envelope* Protein, Dengue virus 4 (395a.a, sf9, His)** E protein; DENV; dengue virus (DENV) (type 4, strain Philippines/H241/1956) E / envelope protein (ECD, His Tag)	Virus	Sf9 insect cells
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles.During entry, NS1 induces genome penetration into the host cytoplasm.E/Envelope Protein, Dengue virus 4 (395a.a, sf9, His) is the recombinant Virus-derived E/Envelope protein, expressed by Sf9 insect cells , with C-His labeled tag.

	*E/Envelope* Protein, Dengue virus 2 (429a.a, sf9, His)** E protein; DENV; dengue virus (DENV) (type 2, strain New Guinea C/PUO-218 hybrid) E / envelope protein (ECD, His Tag)	Virus	Sf9 insect cells
	E/Envelope Protein, Dengue virus 2 (429a.a, sf9, His) is the recombinant Virus-derived E/Envelope protein, expressed by Sf9 insect cells, with C-His labeled tag.

	*E/Envelope* Protein, Dengue virus 4 (101a.a, HEK293, His)** E protein; DENV; dengue virus (DENV) (type 4, strain Philippines/H241/1956) E / envelope protein (aa 579-679, His Tag)	Virus	HEK293
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles.During entry, NS1 induces genome penetration into the host cytoplasm.E/Envelope Protein, Dengue virus 4 (101a.a, HEK293, His) is the recombinant Virus-derived E/Envelope protein, expressed by HEK293 , with C-His labeled tag.

	*E/Envelope* Protein, Dengue virus 1 (101a.a, HEK293, His)** E protein; DENV; DENV envelope / DENV-E protein (His Tag)	Virus	HEK293
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles.During entry, NS1 induces genome penetration into the host cytoplasm.E/Envelope Protein, Dengue virus 1 (101a.a, HEK293, His) is the recombinant Virus-derived E/Envelope protein, expressed by HEK293 , with C-His labeled tag.

	*E/Envelope* Protein, Dengue virus 2 (102a.a, P.pastoris, His)** E protein; DENV; dengue virus (DENV) (type 2, strain New Guinea C/PUO-218 hybrid) E / envelope protein (Domain III, His Tag)	Virus	P. pastoris
	E/Envelope Protein, Dengue virus 2 (102a.a, P.pastoris, His) is the recombinant Virus-derived E/Envelope protein, expressed by P. pastoris, with C-His labeled tag.

	*E/Envelope* Protein, Dengue virus 3 (429a.a, HEK293, His)** E protein; DENV; dengue virus (DENV)(type 3, strain Philippines/H87/1956) E / envelope protein (aa 247-675, ECD, His Tag)	Virus	HEK293
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles. During entry, NS1 induces genome penetration into the host cytoplasm. E/Envelope Protein, Dengue virus 3 (429a.a, HEK293, His) is the recombinant Virus-derived E/Envelope protein, expressed by HEK293 , with C-His labeled tag.

	*E/Envelope* Protein, Dengue virus 2 (103a.a, P.pastoris, His)** E protein; DENV; dengue virus (DENV) (type 2, strain New Guinea C/PUO-218 hybrid) E / envelope protein (Domain III, His Tag)	Virus	P. pastoris
	E/Envelope Protein, Dengue virus 2 (103a.a, P.pastoris, His) is the recombinant Virus-derived E/Envelope protein, expressed by P. pastoris, with C-His labeled tag.

	*E/Envelope* Protein, Dengue virus 2 (399a.a, T356R, Q357E, W381R, L387R, sf9, His)** E protein; DENV; dengue virus (DENV) (type 2, strain New Guinea C/PUO-218 hybrid) E / envelope protein (His Tag)	Virus	Sf9 insect cells
	E/Envelope Protein, Dengue virus 2 (399a.a, T356R, Q357E, W381R, L387R, sf9, His) is the recombinant Virus-derived E/Envelope protein, expressed by Sf9 insect cells, with C-His labeled tag.

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