Search Result

Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

endocrine and metabolic diseases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ACSL Family (1) Acyltransferase (2) Adrenergic Receptor (1) Amino Acid Derivatives (1) Anaplastic lymphoma kinase (ALK) (1) Apolipoprotein (1) Apoptosis (2) Autophagy (2) Btk (1) CETP (1) Endogenous Metabolite (1) Ferroptosis (2) Glucocorticoid Receptor (1) HMG-CoA Reductase (HMGCR) (1) Interleukin Related (1) Keap1-Nrf2 (1) Neuropeptide Y Receptor (2) Phosphatase (2) TGF-beta/Smad (1) TGF-β Receptor (1) TNF Receptor (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (4) Endocrinology (7) Infection (1) Inflammation/Immunology (2) Metabolic Disease (15) Neurological Disease (2)

By Targets:

ACSL Family (1)

Acyltransferase (2)

Adrenergic Receptor (1)

Amino Acid Derivatives (1)

Anaplastic lymphoma kinase (ALK) (1)

Apolipoprotein (1)

Apoptosis (2)

Autophagy (2)

Btk (1)

CETP (1)

Endogenous Metabolite (1)

Ferroptosis (2)

Glucocorticoid Receptor (1)

HMG-CoA Reductase (HMGCR) (1)

Interleukin Related (1)

Keap1-Nrf2 (1)

Neuropeptide Y Receptor (2)

Phosphatase (2)

TGF-beta/Smad (1)

TGF-β Receptor (1)

TNF Receptor (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (4)

Endocrinology (7)

Infection (1)

Inflammation/Immunology (2)

Metabolic Disease (15)

Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1051

Flumethasone 1 Publications Verification Flumetasone	Glucocorticoid Receptor TNF Receptor Interleukin Related Keap1-Nrf2	Inflammation/Immunology Endocrinology Cancer
Flumethasone (Flumetasone) is an orally active, high selective and potent glucocorticoid receptor (GR) agonist. Flumethasone activates GR to inhibit nuclear factor kappa B (NF-κB)-mediated pro-inflammatory cytokine production (TNF-α, IL-1β) and promotes anti-inflammatory gene expression (IL-10), while also regulating metabolic enzyme activity (tyrosine aminotransferase induction). Flumethasone is promising for research of inflammatory diseases, cancer, and endocrine regulation .

HY-P991504

LAE-102	Anaplastic lymphoma kinase (ALK) TGF-β Receptor TGF-beta/Smad	Metabolic Disease Cancer
LAE-102 is the selective anti-ActRIIA (activin receptor type IIA or ACVR2) monoclonal antibody. LAE-102 increases muscle mass and reduces fat mass. LAE102 can increase serum activin A levels in vivo. LAE-102 is promising for research of obesity .

HY-P1723

Spexin 2 Publications Verification Neuropeptide Q	Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy	Cardiovascular Disease Neurological Disease
Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .

HY-W414588

Colestolone	HMG-CoA Reductase (HMGCR) CETP	Metabolic Disease
Colestolone is a 15-ketosterol compound and an orally active inhibitor of HMG-CoA reductase. Colestolone can inhibit the activity of cholesteryl ester transfer protein (CETP) in vitro (IC₅₀= 660 μM). Colestolone is a cholesterol-lowering agent, and can be used in the research of endocrine and metabolic diseases such as hyperlipidemia .

HY-177850

ACSL5-IN-3	ACSL Family	Metabolic Disease Endocrinology Cancer
ACSL5-IN-3 (page 115 line 11) is an ACSL5 inhibitor. ACSL5-IN-3 can be used for research of tumours, digestive system diseases, and endocrine and metabolic diseases .

HY-W343900

Hydroxyproline DL-Hydroxyproline	Amino Acid Derivatives	Metabolic Disease
Hydroxyproline (DL-Hydroxyproline) is a non-essential amino acid and one of the main components of collagen tissue. Hydroxyproline can be used in research on endocrine and metabolic diseases, as well as genetic diseases and malformations. Hydroxyproline can also serve as a biomarker .

HY-127055

Tiadenol	Apolipoprotein	Metabolic Disease Endocrinology
Tiadenol is an absorbable hypolipidemic agent. Tiadenol can effectively reduce triglycerides and decrease the level of apolipoprotein E in very low-density lipoproteins in hyperlipoproteinemia. Tiadenol causes hepatomegaly in rats and affects their hepatic lipid levels, cholesterol synthesis and absorption at high doses. Tiadenol can be used in the research of endocrine and metabolic diseases such as hyperlipidemia .

HY-P1723A

Spexin TFA Neuropeptide Q TFA	Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy	Cardiovascular Disease Metabolic Disease
Spexin (Neuropeptide Q) TFA is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin TFA can function through both central and peripheral actions. Spexin TFA upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin TFA improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin TFA can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .

HY-128005

ML085	Phosphatase	Metabolic Disease Endocrinology Cancer
ML085 is an inhibitor of placental alkaline phosphatase (PLAP). ML085 can be used in the research of testicular tumors, endocrine and metabolic diseases, and genitourinary system diseases .

HY-129999

PNU-106817	Others	Metabolic Disease Endocrinology
PNU-106817 is a biologically active substance. PNU-106817 can be used in the research of endocrine and metabolic diseases such as obesity and type 2 diabetes.

HY-106938

Eldacimibe WAY-ACA 147	Acyltransferase	Cardiovascular Disease Metabolic Disease
Eldacimibe is an ACAT2 inhibitor. Eldacimibe can lower plasma cholesterol levels by blocking cholesterol absorption and can prevent macrophages from turning into foam cells. Eldacimibe can be used in the study of cardiovascular diseases (atherosclerosis), endocrine and metabolic diseases (hypercholesterolemia) .

HY-160168

BTK-IN-31	Btk	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
BTK-IN-31 (Compound 2) is a selective, non-covalently reversible, and blood-brain barrier (BBB) permeable Btk inhibitor. BTK-IN-31 has research potential in immune disorders, cancer, cardiovascular disease, viral infections, inflammation, metabolic/endocrine dysfunction, and neurological disorders .

HY-167680

Denagliptin GSK823093	Endogenous Metabolite	Metabolic Disease
Denagliptin (GSK823093) is a small molecule dipeptidyl peptidase IV (DPP-4) inhibitor with activity for the suppression of endocrine and metabolic diseases. Denagliptin can be used to study type 2 diabetes. Denagliptin is stable in the solid state but degrades in solution and in mixtures with various excipients. Denagliptin also exhibits degradation in capsules, mainly through cyclization reactions to form (3S,7S,8aS) aminoamines to provide further synthetic materials. The degradation pathway of Denagliptin was elucidated, providing data to support its formulation development and regulatory filings .

HY-118815

Lodinixil	Others	Metabolic Disease
Lodinixil is a cholesterol inhibitor. Lodinixil can be used in research on endocrine and metabolic diseases such as hyperlipidemia .

HY-19112

447C88	Acyltransferase	Metabolic Disease Endocrinology
447C88 is an acyl-coenzyme A cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ of 23 nM. 447C88 can reduce plasma cholesterol levels and can be used in the research of endocrine and metabolic diseases such as hyperlipidemia .

HY-116725

Glipentide	Phosphatase	Metabolic Disease
Glipentide is a sulfonylurea receptor agonist. Glipentide increases the concentration of fructose-2,6-bisphosphate in rat hepatocytes and inhibits basal gluconeogenesis. Glipentide can reduce glycerol production in rat adipose tissue. Glipentide can be used in research on endocrine and metabolic diseases such as diabetes .

HY-19002

BRL-26830A	Adrenergic Receptor	Metabolic Disease
BRL-26830A is a β-adrenergic receptor agonist. BRL-26830A reduces body weight and increases metabolic rate in obese mouse models. BRL-26830A stimulates insulin release and significantly reduces blood glucose levels in ICR mouse models. BRL-26830A can be used to study endocrine and metabolic diseases such as obesity and diabetes .

Cat. No.	Product Name

HY-L211

Human Hormone Compound Library	87 compounds
Hormones are a class of biologically active substances secreted by endocrine gland cells, which are transported through the circulatory system to various parts of the body, and precisely act on specific target organs or cells, playing a crucial role in regulating the growth, development, metabolism, and reproduction of organisms. The mechanisms of hormone action are diverse and complex. Some hormones (such as corticosteroids, vitamin D, and thyroid hormones) can enter the cell interior and interact with receptors in the nucleus, thereby regulating gene expression and affecting cell function. Other hormones (such as growth hormone and thyrotropin-releasing hormone) bind directly to receptors on the cell surface, exerting their effects by regulating enzyme activity or influencing the state of ion channels. Additionally, hormones play a key role in the study of endocrine and metabolic diseases, and are closely related to the development of diseases such as diabetes and thyroid diseases. MCE has included 87 human hormone compounds, which is of great significance for the study of human metabolic pathways, and can also be used to build a metabonomics database.

Human Hormone Compound Library

87 compounds

Hormones are a class of biologically active substances secreted by endocrine gland cells, which are transported through the circulatory system to various parts of the body, and precisely act on specific target organs or cells, playing a crucial role in regulating the growth, development, metabolism, and reproduction of organisms. The mechanisms of hormone action are diverse and complex. Some hormones (such as corticosteroids, vitamin D, and thyroid hormones) can enter the cell interior and interact with receptors in the nucleus, thereby regulating gene expression and affecting cell function. Other hormones (such as growth hormone and thyrotropin-releasing hormone) bind directly to receptors on the cell surface, exerting their effects by regulating enzyme activity or influencing the state of ion channels. Additionally, hormones play a key role in the study of endocrine and metabolic diseases, and are closely related to the development of diseases such as diabetes and thyroid diseases.

MCE has included 87 human hormone compounds, which is of great significance for the study of human metabolic pathways, and can also be used to build a metabonomics database.

Cat. No.	Product Name	Target	Research Area

HY-P1723

Spexin 2 Publications Verification Neuropeptide Q	Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy	Cardiovascular Disease Neurological Disease
Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .

HY-P1723A

Spexin TFA Neuropeptide Q TFA	Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy	Cardiovascular Disease Metabolic Disease
Spexin (Neuropeptide Q) TFA is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin TFA can function through both central and peripheral actions. Spexin TFA upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin TFA improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin TFA can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991504

LAE-102	Anaplastic lymphoma kinase (ALK) TGF-β Receptor TGF-beta/Smad	Metabolic Disease Cancer
LAE-102 is the selective anti-ActRIIA (activin receptor type IIA or ACVR2) monoclonal antibody. LAE-102 increases muscle mass and reduces fat mass. LAE102 can increase serum activin A levels in vivo. LAE-102 is promising for research of obesity .

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