2. Protein Tyrosine Kinase/RTK TGF-beta/Smad Stem Cell/Wnt
  3. Anaplastic lymphoma kinase (ALK) TGF-β Receptor TGF-beta/Smad
  4. LAE-102

LAE-102 is the selective anti-ActRIIA (activin receptor type IIA or ACVR2) monoclonal antibody. LAE-102 increases muscle mass and reduces fat mass. LAE102 can increase serum activin A levels in vivo. LAE-102 is promising for research of obesity.

For research use only. We do not sell to patients.

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Based on 1 publication(s) in Google Scholar

LAE-102 Related Antibodies

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Description

LAE-102 is the selective anti-ActRIIA (activin receptor type IIA or ACVR2) monoclonal antibody. LAE-102 increases muscle mass and reduces fat mass. LAE102 can increase serum activin A levels in vivo. LAE-102 is promising for research of obesity[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

ACVR2A
In Vitro

ACVR2A, also known as Activin RIIA, is an activin type II receptor. On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. ACVR2A is a receptor for Activin A, Activin B and Inhibin A.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LAE-102 Related Antibodies
Clinical Trial
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

144.92 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[LAE-102]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized Hu-ActivinRIIA/ACVR2A Protein, His Tag can bind LAE-102. The EC50 for this effect is 6.518 ng/mL.
Purity & Documentation
References
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LAE-102 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LAE-102LAE102LAE 102Anaplastic lymphoma kinase (ALK)TGF-β ReceptorTGF-beta/SmadAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Transforming growth factor beta receptorsTransforming growth factor betaACTRIIAACVR2endocrine and metabolic diseasestumorsand respiratory system diseasesInhibitorinhibitorinhibit

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LAE-102
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HY-P991504
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