Hydroxyproline
Based on 1 Customer Validation
Hydroxyproline (DL-Hydroxyproline) is a non-essential amino acid and one of the main components of collagenous tissues. Hydroxyproline acts as a substrate for mitochondrial hydroxyproline oxidase to generate ROS. Hydroxyproline promotes the synthesis of glutathione, DNA, heme and proteins via conversion to Glycine (HY-Y0966). Hydroxyproline promotes the activation of caspase-9 and apoptosis in cancer cells treated with Doxorubicin. Hydroxyproline serves as a biochemical marker. Hydroxyproline is used in research related to various diseases including colon cancer, diabetes and arthritis.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 6912-67-0
- Formula: C5H9NO3
- Molecular Weight:131.13
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
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Biological Activity
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Caspase-9 |
Hydroxyproline (0.5 mM) inhibits hydroxyl radical generation via the Fenton reaction[1].
Hydroxyproline (0.1-10 mM) promotes caspase-9 activation and apoptosis in adriamycin-treated human colon carcinoma RKO cells via ROS generation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Hydroxyproline (oral; dietary supplementation) enhances the growth performance of turbot fed high plant protein source-based diets[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 6912-67-0
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Appearance Solid
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Molecular Weight 131.13
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Formula C5H9NO3
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Color White to off-white
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SMILES
O=C(C1NCC(C1)O)O
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Synonyms
DL-Hydroxyproline
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
H2O : 200 mg/mL (1525.20 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Wu Z, et al. Metabolism, Nutrition, and Redox Signaling of Hydroxyproline. Antioxidants & redox signaling. 2019 Feb 01;30(4):674-682. [Content Brief]
[2]. Srivastava AK, et al. Hydroxyproline: A Potential Biochemical Marker and Its Role in the Pathogenesis of Different Diseases. Current protein & peptide science. 2016;17(6):596-602. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.6260 mL | 38.1301 mL | 76.2602 mL | 190.6505 mL |
| 5 mM | 1.5252 mL | 7.6260 mL | 15.2520 mL | 38.1301 mL | |
| 10 mM | 0.7626 mL | 3.8130 mL | 7.6260 mL | 19.0650 mL | |
| 15 mM | 0.5084 mL | 2.5420 mL | 5.0840 mL | 12.7100 mL | |
| 20 mM | 0.3813 mL | 1.9065 mL | 3.8130 mL | 9.5325 mL | |
| 25 mM | 0.3050 mL | 1.5252 mL | 3.0504 mL | 7.6260 mL | |
| 30 mM | 0.2542 mL | 1.2710 mL | 2.5420 mL | 6.3550 mL | |
| 40 mM | 0.1907 mL | 0.9533 mL | 1.9065 mL | 4.7663 mL | |
| 50 mM | 0.1525 mL | 0.7626 mL | 1.5252 mL | 3.8130 mL | |
| 60 mM | 0.1271 mL | 0.6355 mL | 1.2710 mL | 3.1775 mL | |
| 80 mM | 0.0953 mL | 0.4766 mL | 0.9533 mL | 2.3831 mL | |
| 100 mM | 0.0763 mL | 0.3813 mL | 0.7626 mL | 1.9065 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Hydroxyproline Related Classifications
HY-W343900 Related Classifications
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