25 Results for "

gut microbiota metabolite

" in MedChemExpress (MCE) Product Catalog:
Products (25)

25 Results for "gut microbiota metabolite" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-W011910
CAS No.: 2642-37-7
Potassium 1H-indol-3-yl sulfate is a metabolite of tryptophan, produced by intestinal microorganisms and combined with sulfate in the liver before entering the circulatory system. Potassium 1H-indol-3-yl sulfate is a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) and a urinary toxin. Potassium 1H-indol-3-yl sulfate can be used for research on kidney diseases .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-N7387
CAS No.: 2304-89-4
Synonyms: 3-Dehydrocholic acid
3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P4633
CAS No.: 7432-23-7
γ-Glu-Tyr is an orally active gut microbiota-derived metabolite and a competitive DPP-IV inhibitor with an IC50 of 6.77 mM against hDPP-IV. γ-Glu-Tyr weakly activates hCaSR. γ-Glu-Tyr decreases colonic pro-inflammatory cytokine (IL-6, IL-1β, TNF-α) levels. γ-Glu-Tyr activates the cAMP/PKA signaling pathway and inhibits NF-κB phosphorylation, thereby reducing inflammatory responses. γ-Glu-Tyr can be used for research on type 2 diabetes and ulcerative colitis .
loading...
    loading...
Cat. No.: HY-113270A
CAS No.: 6249-56-5
Purity:  ≥98.0%
Synonyms: γ-Butyrobetaine chloride; Deoxycarnitine chloride
Actinine (γ-Butyrobetaine) chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat.
loading...
    loading...
Cat. No.: HY-W032915
CAS No.: 2270-20-4
Synonyms: 5-Phenylpentanoic acid
5-Phenylvaleric acid (5-Phenylpentanoic acid) is a major metabolite produced by the gut microbiota during the metabolism of flavan-3-ols and can serve as a biomarker for flavan-3-ol intake. 5-Phenylvaleric acid can also be used as a raw material for the synthesis of polyhydroxyalkanoates .
loading...
    loading...
Cat. No.: HY-N12326
CAS No.: 1350028-90-8
Multiflorin A is an orally active active ingredient of traditional herbal laxative, Pruni semen. Multiflorin A inhibits aromatase enzyme activity with an IC50 of 15.5 μM. Multiflorin A also inhibits quinone reductase 2 (QR2) and COX-2 enzyme. Multiflorin A has purgative activity and reduces postprandial blood glucose in mice. Multiflorin A modulates intestinal glucose transporters, tight junction proteins, and aquaporins, reshapes gut microbiota, and alters faecal metabolites. Multiflorin A can be used for the research of constipation and diabetes .
loading...
    loading...
Cat. No.: HY-128442
CAS No.: 937-34-8
Purity:  99.56%
Synonyms: Phenyl hydrogen sulfate
Phenyl sulfate (Phenyl hydrogen sulfate) is an orally active gut microbiota-derived metabolite. Phenyl sulfate undergoes hepatic sulfation via SULT1A1. Phenyl sulfate induces podocyte injury, albuminuria, renal pro-inflammatory and pro-fibrotic effects, cytotoxicity, glutathione depletion, mitochondrial dysfunction, and sensitizes renal tubular cells to oxidative stress. Phenyl sulfate can be used in research on diabetic nephropathy .
loading...
    loading...
Cat. No.: HY-N4075
CAS No.: 21255-69-6
O-Desmethylangolensin is a metabolite of soy isoflavone, daidzein metabolized by gut microbiota. O-Desmethylangolensin possesses antioxidant activity .
loading...
    loading...
Cat. No.: HY-112948
CAS No.: 256928-75-3
Purity:  99.66%
Synonyms: 2MBC
2-Methylbutyrylcarnitine (2MBC) is an orally active short-chain branched-chain acylcarnitine and a gut microbiota co-metabolite produced from 2-methylbutyric acid via branched-chain amino acid catabolism. 2-Methylbutyrylcarnitine activates platelet integrin α2β1 (Kd = 10.6 μM), initiates the downstream p38‑cPLA2 signaling cascade, elevates TXA2 production, and thereby enhances platelet hyperreactivity. 2-Methylbutyrylcarnitine can be used in research on atherosclerosis and thrombosis .
loading...
    loading...
Cat. No.: HY-113270AS
CAS No.: 85806-17-3
Purity:  ≥98.0%
Synonyms: γ-Butyrobetaine-d9 hydrochloride; Deoxycarnitine-d9 hydrochloride
Actinine-d9 chloride is the deuterium labeled Actinine chloride. Actinine chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat .
loading...
    loading...
Cat. No.: HY-W015229R
CAS No.: 830-96-6
Synonyms: Indole-3-propionic acid (Standard); 3-IPA (Standard)
3-Indolepropionic acid (Standard) is the analytical standard of 3-Indolepropionic acid. This product is intended for research and analytical applications. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease. In Vitro: 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease . 3-Indolepropionic acid is a more potent scavenger of hydroxyl radicals than melatonin. Similar to melatonin but unlike other antioxidants, 3-Indolepropionic acid scavenges radicals without subsequently generating reactive and pro-oxidant intermediate compounds . It is also suggested that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of type 2 diabetes (T2D) that may mediate its protective effect by preservation of β-cell function .
loading...
    loading...
Cat. No.: HY-W011730
CAS No.: 87178-63-0
Synonyms: Leu-Pro hydrochloride
Leucylproline hydrochloride (Leu‑Pro hydrochloride) is a dipeptide composed of L‑leucine and L‑proline, and it is a fecal secondary metabolite associated with the gut microbiota. Leucylproline hydrochloride is taken up by Lactococcus lactis cells via the di‑tripeptide transport system, and mediates transcriptional repression of the prtP/prtM promoter after intracellular accumulation. The content of Leucylproline hydrochloride is significantly decreased in fecal samples related to hepatolenticular degeneration. Leucylproline hydrochloride can be used for the study of metabolism‑related diseases .
loading...
    loading...
Cat. No.: HY-N8049
CAS No.: 531512-26-2
Urolithin M7 is an orally active metabolite, which is generated through gut microbiota metabolism. Urolithin M7 inhibits oxidative stress and modulates inflammatory signaling pathways. Urolithin M7 is promising for research of gut microbiota metabolism and cardiovascular diseases .
loading...
    loading...
Cat. No.: HY-113270AR
CAS No.: 6249-56-5
Synonyms: γ-Butyrobetaine chloride (Standard); Deoxycarnitine chloride (Standard)
Actinine (chloride) (Standard) is the analytical standard of Actinine (chloride). This product is intended for research and analytical applications. Actinine (γ-Butyrobetaine) chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat.
loading...
    loading...
Cat. No.: HY-W654264
Synonyms: 2MBC chloride
2-Methylbutyrylcarnitine chloride (2MBC chloride) is an orally active short-chain branched-chain acylcarnitine and a gut microbiota co-metabolite produced from 2-methylbutyric acid via branched-chain amino acid catabolism. 2-Methylbutyrylcarnitine chloride activates platelet integrin α2β1 (Kd = 10.6 μM), initiates the downstream p38‑cPLA2 signaling cascade, elevates TXA2 production, and thereby enhances platelet hyperreactivity. 2-Methylbutyrylcarnitine chloride can be used in research on atherosclerosis and thrombosis .
loading...
    loading...
Cat. No.: HY-114729
CAS No.: 6403-35-6
Synonyms: Leu-Pro
Leucylproline (Leu‑Pro) is a dipeptide composed of L‑leucine and L‑proline, and it is a fecal secondary metabolite associated with the gut microbiota. Leucylproline is taken up by Lactococcus lactis cells via the di‑tripeptide transport system, and mediates transcriptional repression of the prtP/prtM promoter after intracellular accumulation. The content of leucylproline is significantly decreased in fecal samples related to hepatolenticular degeneration. Leucylproline can be used for the study of metabolism‑related diseases .
loading...
    loading...
Cat. No.: HY-W740611
CAS No.: 547-96-6
Trihydroxycoprostane (THCP) is a polyhydroxysterane compound with a 5β configuration. ITrihydroxycoprostane acts as a key intermediate in the biosynthesis of bile acids from cholesterol and also serves as an important sterol metabolite generated by host-gut microbiota interactions. Trihydroxycoprostane can be used for mechanistic studies of diseases such as non-alcoholic fatty liver disease, inflammatory bowel disease, and bile acid metabolism disorders .
loading...
    loading...
Cat. No.: HY-145534
CAS No.: 152064-94-3
Synonyms: CAR 8:1; C8:1 Carnitine; L-Carnitine trans-2-octenoyl ester
Research Areas:  

Metabolic Disease

trans-2-Octenoyl-L-carnitine (CAR 8:1; C8:1 Carnitine; L-Carnitine trans-2-octenoyl ester) is a medium-chain monounsaturated acylcarnitine that rarely occurs in healthy humans, and it is a fatty acid oxidation-related metabolite associated with gut microbiota-host co-metabolism. trans-2-Octenoyl-L-carnitine can serve as an analytical reference standard for qualitative and quantitative detection of carnitine metabolites in scientific research, particularly in human urine samples.
loading...
    loading...
Cat. No.: HY-114852
CAS No.: 169195-23-7
Target:  

Endogenous Metabolite

Research Areas:  

Others

Pheleuin (Compound PZN10), a pyrazinone, is found in gut microbiota-derived metabolites .
loading...
    loading...
Cat. No.: HY-N7387R
CAS No.: 2304-89-4
Synonyms: 3-Dehydrocholic acid (Standard)
Butylphthalide (Standard) is the analytical standard of Butylphthalide. This product is intended for research and analytical applications. Butylphthalide (3-n-Butylphthalide) is an active molecule against cerebral ischemia. It was originally isolated from celery species and has been shown to be effective in stroke animal models.
loading...
    loading...