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Results for "

gut microbiota metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (1) Endogenous Metabolite (16) Aryl Hydrocarbon Receptor (1) Biochemical Assay Reagents (1) Cytochrome P450 (1) Drug Intermediate (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Reactive Oxygen Species (ROS) (1) Reference Standards (5) UGT (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (4) Inflammation/Immunology (2) Metabolic Disease (12) Neurological Disease (1)

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Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Metabolite Endogenous Metabolite

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113270A

Actinine chloride γ-Butyrobetaine chloride; Deoxycarnitine chloride	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Actinine (γ-Butyrobetaine) chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat.

HY-W011910

Potassium 1H-indol-3-yl sulfate 1 Publications Verification	Endogenous Metabolite Aryl Hydrocarbon Receptor Cytochrome P450 UGT Interleukin Related	Metabolic Disease
Potassium 1H-indol-3-yl sulfate is a metabolite of tryptophan, produced by intestinal microorganisms and combined with sulfate in the liver before entering the circulatory system. Potassium 1H-indol-3-yl sulfate is a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) and a urinary toxin. Potassium 1H-indol-3-yl sulfate can be used for research on kidney diseases .

HY-N7387

3-Oxocholic acid 3-Dehydrocholic acid	Endogenous Metabolite	Metabolic Disease
3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals .

HY-W032915

5-Phenylvaleric acid 5-Phenylpentanoic acid	Endogenous Metabolite	Others
5-Phenylvaleric acid (5-Phenylpentanoic acid) is a major metabolite produced by the gut microbiota during the metabolism of flavan-3-ols and can serve as a biomarker for flavan-3-ol intake. 5-Phenylvaleric acid can also be used as a raw material for the synthesis of polyhydroxyalkanoates .

HY-128442

Phenyl sulfate Phenyl hydrogen sulfate	Endogenous Metabolite	Metabolic Disease
Phenyl sulfate is an orally active gut microbiota-derived metabolite. Phenyl sulfate induces albuminuria and podocyte damage in experimental models of diabetes. Phenyl sulfate can be used as a disease marker in diabetic kidney disease .

HY-N4075

O-Desmethylangolensin	Endogenous Metabolite	Metabolic Disease Cancer
O-Desmethylangolensin is a metabolite of soy isoflavone, daidzein metabolized by gut microbiota. O-Desmethylangolensin possesses antioxidant activity .

HY-113270AS

Actinine-d9 chloride γ-Butyrobetaine-d9 hydrochloride; Deoxycarnitine-d9 hydrochloride	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Actinine-d₉ chloride is the deuterium labeled Actinine chloride. Actinine chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat .

HY-W015229R

3-Indolepropionic acid (Standard) Indole-3-propionic acid (Standard); 3-IPA (Standard)	Reference Standards Endogenous Metabolite Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease
3-Indolepropionic acid (Standard) is the analytical standard of 3-Indolepropionic acid. This product is intended for research and analytical applications. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease. In Vitro: 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease . 3-Indolepropionic acid is a more potent scavenger of hydroxyl radicals than melatonin. Similar to melatonin but unlike other antioxidants, 3-Indolepropionic acid scavenges radicals without subsequently generating reactive and pro-oxidant intermediate compounds . It is also suggested that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of type 2 diabetes (T2D) that may mediate its protective effect by preservation of β-cell function .

HY-N8049

Urolithin M7	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Urolithin M7 is an orally active metabolite, which is generated through gut microbiota metabolism. Urolithin M7 inhibits oxidative stress and modulates inflammatory signaling pathways. Urolithin M7 is promising for research of gut microbiota metabolism and cardiovascular diseases .

HY-W509797

5-(3',4'-Dihydroxyphenyl)-γ-valerolactone	Drug Metabolite	Inflammation/Immunology
5-(3',4'-Dihydroxyphenyl)-γ-valerolactone is a gut microbiota metabolite of (-)-Epicatechin (HY-N0001). 5-(3',4'-Dihydroxyphenyl)-γ-valerolactone exhibits antioxidant activity .

HY-113270AR

Actinine chloride (Standard) γ-Butyrobetaine chloride (Standard); Deoxycarnitine chloride (Standard)	Endogenous Metabolite Reference Standards	Cardiovascular Disease Metabolic Disease
Actinine (chloride) (Standard) is the analytical standard of Actinine (chloride). This product is intended for research and analytical applications. Actinine (γ-Butyrobetaine) chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat.

HY-W740611

Trihydroxycoprostane	Drug Intermediate	Inflammation/Immunology
Trihydroxycoprostane (THCP) is a polyhydroxysterane compound with a 5β configuration. ITrihydroxycoprostane acts as a key intermediate in the biosynthesis of bile acids from cholesterol and also serves as an important sterol metabolite generated by host-gut microbiota interactions. Trihydroxycoprostane can be used for mechanistic studies of diseases such as non-alcoholic fatty liver disease, inflammatory bowel disease, and bile acid metabolism disorders .

HY-145534

trans-2-Octenoyl-L-carnitine CAR 8:1; C8:1 Carnitine; L-Carnitine trans-2-octenoyl ester	Biochemical Assay Reagents	Metabolic Disease
trans-2-Octenoyl-L-carnitine (CAR 8:1; C8:1 Carnitine; L-Carnitine trans-2-octenoyl ester) is a medium-chain monounsaturated acylcarnitine that rarely occurs in healthy humans, and it is a fatty acid oxidation-related metabolite associated with gut microbiota-host co-metabolism. trans-2-Octenoyl-L-carnitine can serve as an analytical reference standard for qualitative and quantitative detection of carnitine metabolites in scientific research, particularly in human urine samples.

HY-114852

Pheleuin	Endogenous Metabolite	Others
Pheleuin (Compound PZN10), a pyrazinone, is found in gut microbiota-derived metabolites .

HY-128442R

Phenyl sulfate (Standard) Phenyl hydrogen sulfate (Standard)	Endogenous Metabolite Reference Standards	Metabolic Disease
Phenyl sulfate (Standard) is the analytical standard of Phenyl sulfate. This product is intended for research and analytical applications. Phenyl sulfate is an orally active gut microbiota-derived metabolite. Phenyl sulfate induces albuminuria and podocyte damage in experimental models of diabetes. Phenyl sulfate can be used as a disease marker in diabetic kidney disease .

HY-N7387R

3-Oxocholic acid (Standard) 3-Dehydrocholic acid (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Butylphthalide (Standard) is the analytical standard of Butylphthalide. This product is intended for research and analytical applications. Butylphthalide (3-n-Butylphthalide) is an active molecule against cerebral ischemia. It was originally isolated from celery species and has been shown to be effective in stroke animal models.

HY-153993

Pyrocatechol sulfate	Endogenous Metabolite	Others
Pyrocatechol sulfate is a phenolic metabolite present in human blood plasma, associated with the intake of certain foods such as berries and the status of the gut microbiota. Pyrocatechol sulfate can serve as a biomarker for uremia. Along with other phenolic sulfates, Pyrocatechol sulfate plays a role in regulating various biological functions, including those related to brain health and the rhythmic beating of cardiomyocytes .

HY-W032915R

5-Phenylvaleric acid (Standard) 5-Phenylpentanoic acid (Standard)	Reference Standards Endogenous Metabolite	Others
5-Phenylvaleric acid (Standard) is an analytical standard for 5-Phenylvaleric acid (HY-W032915). This product is used for research and analytical applications. 5-Phenylvaleric acid (5-Phenylpentanoic acid) is a major metabolite produced by the gut microbiota during the metabolism of flavan-3-ols and can serve as a biomarker for flavan-3-ol intake. 5-Phenylvaleric acid can also be used as a raw material for the synthesis of polyhydroxyalkanoates.

HY-W032915S

5-Phenylvaleric acid-d13 5-Phenylpentanoic acid-₁₃	Isotope-Labeled Compounds Endogenous Metabolite	Others
5-Phenylvaleric acid-d₁₃ (5-Phenylpentanoic acid-d₁₃) is the deuterium labeled 5-Phenylvaleric acid (HY-W032915). 5-Phenylvaleric acid (5-Phenylpentanoic acid) is a major metabolite produced by the gut microbiota during the metabolism of flavan-3-ols and can serve as a biomarker for flavan-3-ol intake. 5-Phenylvaleric acid can also be used as a raw material for the synthesis of polyhydroxyalkanoates .

Cat. No.	Product Name

HY-L078

Gut Microbial Metabolite Library	476 compounds
Accumulating evidence has revealed that intestinal microbiota play an important role in human health and disease, including cardiovascular diseases, inflammatory bowel disease, diabetes, obesity, cancer, and depression, etc. Changes in the composition of gut microbiota associated with disease, referred to as dysbiosis, have been linked to pathologies. Indeed, the gut microbiome functions like an endocrine organ, generating bioactive metabolites which play important roles in human metabolism, health, and disease. Gut microbiome has become a novel therapeutic target for many diseases. Analysis and identification of gut microbial metabolite will contribute to the development of therapeutic methods. In order to meet the need of gut microbiome research, MCE carefully selected a unique collection of 476 gut microbial metabolites. MCE gut microbial metabolite library is a powerful tool for gut microbiome research and gut microbiome -related drug discovery.

Gut Microbial Metabolite Library

476 compounds

Accumulating evidence has revealed that intestinal microbiota play an important role in human health and disease, including cardiovascular diseases, inflammatory bowel disease, diabetes, obesity, cancer, and depression, etc. Changes in the composition of gut microbiota associated with disease, referred to as dysbiosis, have been linked to pathologies. Indeed, the gut microbiome functions like an endocrine organ, generating bioactive metabolites which play important roles in human metabolism, health, and disease. Gut microbiome has become a novel therapeutic target for many diseases. Analysis and identification of gut microbial metabolite will contribute to the development of therapeutic methods.

In order to meet the need of gut microbiome research, MCE carefully selected a unique collection of 476 gut microbial metabolites. MCE gut microbial metabolite library is a powerful tool for gut microbiome research and gut microbiome -related drug discovery.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113270A

Actinine chloride γ-Butyrobetaine chloride; Deoxycarnitine chloride	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Actinine (γ-Butyrobetaine) chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat.

HY-W011910

Potassium 1H-indol-3-yl sulfate 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Aryl Hydrocarbon Receptor Cytochrome P450 UGT Interleukin Related
Potassium 1H-indol-3-yl sulfate is a metabolite of tryptophan, produced by intestinal microorganisms and combined with sulfate in the liver before entering the circulatory system. Potassium 1H-indol-3-yl sulfate is a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) and a urinary toxin. Potassium 1H-indol-3-yl sulfate can be used for research on kidney diseases .

HY-N7387

3-Oxocholic acid 3-Dehydrocholic acid	Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals .

HY-W032915

5-Phenylvaleric acid 5-Phenylpentanoic acid	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
5-Phenylvaleric acid (5-Phenylpentanoic acid) is a major metabolite produced by the gut microbiota during the metabolism of flavan-3-ols and can serve as a biomarker for flavan-3-ol intake. 5-Phenylvaleric acid can also be used as a raw material for the synthesis of polyhydroxyalkanoates .

HY-128442

Phenyl sulfate Phenyl hydrogen sulfate	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Phenyl sulfate is an orally active gut microbiota-derived metabolite. Phenyl sulfate induces albuminuria and podocyte damage in experimental models of diabetes. Phenyl sulfate can be used as a disease marker in diabetic kidney disease .

HY-N4075

O-Desmethylangolensin	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
O-Desmethylangolensin is a metabolite of soy isoflavone, daidzein metabolized by gut microbiota. O-Desmethylangolensin possesses antioxidant activity .

HY-W015229R

3-Indolepropionic acid (Standard) Indole-3-propionic acid (Standard); 3-IPA (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Reactive Oxygen Species (ROS)
3-Indolepropionic acid (Standard) is the analytical standard of 3-Indolepropionic acid. This product is intended for research and analytical applications. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease. In Vitro: 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease . 3-Indolepropionic acid is a more potent scavenger of hydroxyl radicals than melatonin. Similar to melatonin but unlike other antioxidants, 3-Indolepropionic acid scavenges radicals without subsequently generating reactive and pro-oxidant intermediate compounds . It is also suggested that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of type 2 diabetes (T2D) that may mediate its protective effect by preservation of β-cell function .

HY-N8049

Urolithin M7	Natural Products Microorganisms Animals Source Classification	Endogenous Metabolite
Urolithin M7 is an orally active metabolite, which is generated through gut microbiota metabolism. Urolithin M7 inhibits oxidative stress and modulates inflammatory signaling pathways. Urolithin M7 is promising for research of gut microbiota metabolism and cardiovascular diseases .

HY-113270AR

Actinine chloride (Standard) γ-Butyrobetaine chloride (Standard); Deoxycarnitine chloride (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Actinine (chloride) (Standard) is the analytical standard of Actinine (chloride). This product is intended for research and analytical applications. Actinine (γ-Butyrobetaine) chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat.

HY-W740611

Trihydroxycoprostane	Structural Classification Endogenous metabolite Steroids Source Classification	Drug Intermediate
Trihydroxycoprostane (THCP) is a polyhydroxysterane compound with a 5β configuration. ITrihydroxycoprostane acts as a key intermediate in the biosynthesis of bile acids from cholesterol and also serves as an important sterol metabolite generated by host-gut microbiota interactions. Trihydroxycoprostane can be used for mechanistic studies of diseases such as non-alcoholic fatty liver disease, inflammatory bowel disease, and bile acid metabolism disorders .

HY-128442R

Phenyl sulfate (Standard) Phenyl hydrogen sulfate (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Phenyl sulfate (Standard) is the analytical standard of Phenyl sulfate. This product is intended for research and analytical applications. Phenyl sulfate is an orally active gut microbiota-derived metabolite. Phenyl sulfate induces albuminuria and podocyte damage in experimental models of diabetes. Phenyl sulfate can be used as a disease marker in diabetic kidney disease .

HY-N7387R

3-Oxocholic acid (Standard) 3-Dehydrocholic acid (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite
Butylphthalide (Standard) is the analytical standard of Butylphthalide. This product is intended for research and analytical applications. Butylphthalide (3-n-Butylphthalide) is an active molecule against cerebral ischemia. It was originally isolated from celery species and has been shown to be effective in stroke animal models.

HY-W032915R

5-Phenylvaleric acid (Standard) 5-Phenylpentanoic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
5-Phenylvaleric acid (Standard) is an analytical standard for 5-Phenylvaleric acid (HY-W032915). This product is used for research and analytical applications. 5-Phenylvaleric acid (5-Phenylpentanoic acid) is a major metabolite produced by the gut microbiota during the metabolism of flavan-3-ols and can serve as a biomarker for flavan-3-ol intake. 5-Phenylvaleric acid can also be used as a raw material for the synthesis of polyhydroxyalkanoates.

Cat. No.	Product Name	Chemical Structure

HY-113270AS

Actinine-d9 chloride
Actinine-d₉ chloride is the deuterium labeled Actinine chloride. Actinine chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat .

HY-W032915S

5-Phenylvaleric acid-d13
5-Phenylvaleric acid-d₁₃ (5-Phenylpentanoic acid-d₁₃) is the deuterium labeled 5-Phenylvaleric acid (HY-W032915). 5-Phenylvaleric acid (5-Phenylpentanoic acid) is a major metabolite produced by the gut microbiota during the metabolism of flavan-3-ols and can serve as a biomarker for flavan-3-ol intake. 5-Phenylvaleric acid can also be used as a raw material for the synthesis of polyhydroxyalkanoates .

5-Phenylvaleric acid-d13

5-Phenylvaleric acid-d₁₃ (5-Phenylpentanoic acid-d₁₃) is the deuterium labeled 5-Phenylvaleric acid (HY-W032915). 5-Phenylvaleric acid (5-Phenylpentanoic acid) is a major metabolite produced by the gut microbiota during the metabolism of flavan-3-ols and can serve as a biomarker for flavan-3-ol intake. 5-Phenylvaleric acid can also be used as a raw material for the synthesis of polyhydroxyalkanoates .

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gut microbiota metabolite

Inhibitors & Agonists

Screening Libraries

NaturalProducts

Isotope-Labeled Compounds

Natural
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