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Results for "

high lipophilicity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (4) Bacterial (1) Biochemical Assay Reagents (6) Calcium Channel (2) Cannabinoid Receptor (1) CCR (1) CETP (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) Drug Intermediate (2) Endogenous Metabolite (4) Environmental Pollutants (2) Fluorescent Dye (2) GABA Receptor (6) Glucocorticoid Receptor (2) Interleukin Related (1) Isotope-Labeled Compounds (5) PAK (1) Photosensitizer (1) Potassium Channel (1) Reference Standards (4) TNF Receptor (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (7) Endocrinology (1) Infection (1) Inflammation/Immunology (5) Metabolic Disease (2) Neurological Disease (9)

By Targets:

Angiotensin Receptor (1)

Angiotensin-converting Enzyme (ACE) (4)

Bacterial (1)

Biochemical Assay Reagents (6)

Calcium Channel (2)

Cannabinoid Receptor (1)

CCR (1)

CETP (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (1)

Dopamine Receptor (1)

Drug Intermediate (2)

Endogenous Metabolite (4)

Environmental Pollutants (2)

Fluorescent Dye (2)

GABA Receptor (6)

Glucocorticoid Receptor (2)

Interleukin Related (1)

Isotope-Labeled Compounds (5)

PAK (1)

Photosensitizer (1)

Potassium Channel (1)

Reference Standards (4)

TNF Receptor (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (7)

Endocrinology (1)

Infection (1)

Inflammation/Immunology (5)

Metabolic Disease (2)

Neurological Disease (9)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: HMG Family

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0007

Baclofen 10+ Cited Publications	GABA Receptor	Neurological Disease
Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABA_B receptor (GABA_BR) agonist with blood-brain barrier permeability. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABA_B receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research .

HY-N2427

Adamantane	Others	Others
Adamantane is a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be studied in pharmacological research to improve the lipophilicity and pharmacological properties of other active products .

HY-B0007C

Baclofen hydrochloride 10+ Cited Publications	GABA Receptor	Neurological Disease
Baclofen hydrochloride, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABA_B receptor (GABA_BR) agonist. Baclofen hydrochloride mimics the action of GABA and produces slow presynaptic inhibition through the GABA_B receptor. Baclofen hydrochloride has high blood brain barrier penetrance. Baclofen hydrochloride has the potential for muscle spasticity research .

HY-136642

Fluocinolone	Glucocorticoid Receptor	Inflammation/Immunology
Fluocinolone is a potent steroid with highly selective glucocorticoid receptor agonist activity. Fluocinolone stabilizes the blood-retinal barrier by enhancing endothelial tight junctions, inhibiting the VEGF pathway and inflammatory factors. Fluocinolone has high lipophilicity, enabling long-term sustained release in the vitreous. Fluocinolone is used in research related to dermatological diseases, diabetic macular edema, uveitis and oral lichen planus .

HY-125139

omega-3 Arachidonic acid ethyl ester, in ethanol, 98% ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%	Biochemical Assay Reagents	Cardiovascular Disease Others
omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

HY-B0929

Octisalate Octyl salicylate; 2-Ethylhexyl salicylate	Environmental Pollutants Biochemical Assay Reagents	Others
Octisalate (Octyl salicylate) is an organic compound with high lipophilicity, which is used in sunscreens and cosmetics that absorbs UVB rays .

HY-A0116A

Trandolaprilate hydrate Trandolaprilat hydrate; RU 44403 hydrate	Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease
Trandolaprilate hydrate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate hydrate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity .

HY-A0116

Trandolaprilate Trandolaprilat; RU 44403	Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease
Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity .

HY-A0116R

Trandolaprilate (Standard) Trandolaprilat (Standard); RU 44403 (Standard)	Reference Standards Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease
Trandolaprilate (Standard) is the analytical standard of Trandolaprilate. This product is intended for research and analytical applications. Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity .

HY-N2427S

Adamantane-d16	Isotope-Labeled Compounds	Others
Adamantane-d₁₆is the deuterium labeled Adamantane (HY-N2427). Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .

HY-133844

Bisbentiamine	Drug Intermediate	Others
Bisbentiamine is a lipophilic thiamine prodrug with pH-dependent solubility. The bioavailability of Bisbentiamine is regulated by diet type, administration time, gastric acidity, and formulation .

HY-119983

7H-Dibenzo[c,g]carbazole DBC	Environmental Pollutants Cytochrome P450	Cancer
7H-Dibenzo[c,g]carbazole (DBC) is an azaarene with high lipophilicity. 7H-Dibenzo[c,g]carbazole has carcinogenic activity and induce DNA adducts in fish, DNA adducts, mutations in diploid human fibroblasts and micronuclei in human blood lymphocytes. 7H-Dibenzo[c,g]carbazole is activated by cytochrome P450 enzymes resulting mainly in the generation of phenolic metabolites .

HY-W783680

Potassium ionophore III	Potassium Channel	Others
Potassium ionophore III (BME-44) is a specific potassium ion carrier with high selectivity for sodium and ammonium ions and high lipophilicity .

HY-157915

HFPB Tetrakis[3,5-bis(1,1,1,3,3,3-hexafluoro-2-methoxy-2-propyl)phenyl]borate, sodium salt, trihydrate	Biochemical Assay Reagents	Others
HFPB (Compound 2) is a type of cation exchanger with high lipophilicity and acid resistivity, which can be used in membrane electrode research .

HY-123039

CP-532623	CETP	Metabolic Disease
CP-532623 is a CETP inhibitor and elevates high-density lipoprotein cholesterolion. CP-532623 is a close structural analogue of Torcetrapib. CP-532623 has highly lipophilic properties .

HY-119216

AZ13711265	PAK	Cancer
AZ13711265 is an orally active PAK1 inhibitor with high selectivity. AZ13711265 has IC₅₀ values of 0.58 nM and 0.11 µM for PAK1 and pPAK1, respectively. AZ13711265 has low lipophilicity and low clearance, and can be used as an in vivo probe compound for PAK1. AZ13711265 can be used in the study of cancer .

HY-122462

Ladirubicin PNU-159548	DNA/RNA Synthesis	Cancer
Ladirubicin (PNU-159548) is a derivative of Daunorubicin (HY-13062A). Ladirubicin exhibits DNA intercalation and DNA alkylating properties, inhibits DNA replication and transcription, causes DNA damage, and thereby exhibits antitumor efficacy. Ladirubicin exhibits the potential to penetrate the blood-brain barrier (BBB) for its high lipophilicity. Ladirubicin exhibits toxicity through suppression of bone marrow activity .

HY-B0007S2

Baclofen-d5 hydrochloride	GABA Receptor Isotope-Labeled Compounds	Neurological Disease
Baclofen-d₅ hydrochloride is deuterated labeled Baclofen (HY-B0007). Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABA_B receptor (GABA_BR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABA_B receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research .

HY-B0007R

Baclofen (Standard)	Reference Standards GABA Receptor	Neurological Disease
Baclofen (Standard) is the analytical standard of Baclofen. This product is intended for research and analytical applications. Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABA_B receptor (GABA_BR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABA_B receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research .

HY-W250129

2,3,4,5-Tetrafluorobenzoyl chloride	Biochemical Assay Reagents	Others
2,3,4,5-Tetrafluorobenzoyl chloride is a fluorinated organic compound that belongs to the class of benzoyl chlorides. It is a colorless liquid with a pungent smell and is mainly used as an intermediate in the synthesis of various pharmaceutical and pesticide compounds. 2,3,4,5-Tetrafluorobenzoyl chloride is an acylating agent that can react with a variety of nucleophiles, including amines, alcohols, and thiols, to form amides, esters, or thioesters, respectively. Its unique fluorine-containing structure can impart desired properties to target molecules, such as increased lipophilicity or increased stability against metabolic degradation. However, due to its high reactivity and potential health hazards, proper safety measures and handling procedures must be followed when using this compound.

HY-121313

Embusartan BAY 10-6734	Angiotensin Receptor	Neurological Disease Endocrinology
Embusartan (BAY 10-6734) is a brain-penetrant and effective AT1 receptor blocker. Embusartan inhibits Ang II binding to brain AT1 receptors in the nuclei of central nervous system (CNS) inside due to high lipophilic character. Embusartan is promising for research of sympathetic hyperactivity and hypertension .

HY-165634

(R)-Azelnidipine	Calcium Channel	Cardiovascular Disease
(R)-Azelnidipine is a highly lipophilic Calcium Channel antagonist with high affinity for vascular walls and antihypertensive activity. (R)-Azelnidipine shows potential for use in cardiovascular disease research .

HY-W504836

Deuteroporphyrin IX dihydrochloride	Photosensitizer	Neurological Disease
Deuteroporphyrin IX (dihydrochloride) is a photosensitizer with high lipophilicity and amphiphilicity, capable of providing photosensitivity for cell membrane systems. Deuteroporphyrin IX (dihydrochloride) can induce irreversible discharge elimination in individual neurons .

HY-160658

AZ760	CCR	Inflammation/Immunology
AZ760 is a CCR8 antagonist. AZ760 shows excellent potency, good lipophilicity and high free fraction in blood. AZ760 exhibits unacceptable hERG inhibition .

HY-157943

Hexyl 5-aminolevulinate HAL	Fluorescent Dye	Cancer
Hexyl 5-aminolevulinate (HAL) is a photosensitizer, and can increase the efficiency of PDT due to the high lipophilicity. Hexyl 5-aminolevulinate can be used for research of photodynamic therapy (PDT) .

HY-119554

Perfluorodecyl bromide PFDB	Biochemical Assay Reagents	Others
Perfluorodecyl bromide (PFDB), a Perflubron (PFOB, HY-B1724) analogue, is a high molecular weight lipophilic fluorocarbon. Perfluorodecyl bromide can be used to prepare phospholipid-stabilized fluorocarbon emulsions .

HY-148850

AZD-2207	Cannabinoid Receptor	Metabolic Disease
AZD-2207 is a cannabinoid receptor CB1 antagonist, known for its high lipophilicity. AZD-2207 has good intestinal permeability in the Caco-2 model and can be used in research related to type 2 diabetes and obesity .

HY-A0116S1

Trandolaprilate-d6	Angiotensin-converting Enzyme (ACE) Endogenous Metabolite	Cardiovascular Disease
Trandolaprilate-d₆ is the deuterium labeled Trandolaprilate . Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity .

HY-W714767

Octisalate-d4 Octyl salicylate-d₄; 2-Ethylhexyl salicylate-d₄	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
Octisalate-d₄ (Octyl salicylate-d₄; 2-Ethylhexyl salicylate-d₄) is the deuterium labeled Octisalate (HY-B0929). Octisalate (Octyl salicylate) is an organic compound with high lipophilicity, which is used in sunscreens and cosmetics that absorbs UVB rays .

HY-N2427R

Adamantane (Standard)	Reference Standards Others	Others
Adamantane (Standard) is the analytical standard of Adamantane. This product is intended for research and analytical applications. Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .

HY-B0007S

Baclofen-d4	Isotope-Labeled Compounds GABA Receptor	Neurological Disease
Baclofen-d₄ is the deuterium labeled Baclofen. Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research .

HY-W707498

Baclofen-d4-1	Isotope-Labeled Compounds GABA Receptor	Neurological Disease
Baclofen-d₄-1 is the deuterium labeled Baclofen (HY-B0007). Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research .

HY-136642R

Fluocinolone (Standard)	Reference Standards Glucocorticoid Receptor	Inflammation/Immunology
Fluocinolone (Standard) is the analytical standard of Fluocinolone (HY-136642). This product is intended for research and analytical applications. Fluocinolone is a potent steroid with highly selective glucocorticoid receptor agonist activity. Fluocinolone stabilizes the blood-retinal barrier by enhancing endothelial tight junctions, inhibiting the VEGF pathway and inflammatory factors. Fluocinolone has high lipophilicity, enabling long-term sustained release in the vitreous. Fluocinolone is used in research related to dermatological diseases, diabetic macular edema, uveitis and oral lichen planus .

HY-185585

JNJ-27548547	Drug Intermediate	Cancer
JNJ-27548547, Mitomycin C (HY-13316) prodrug, is a Mitomycin C and lipophilic group conjugate. JNJ-27548547 undergoes thiolytic cleavage of its dithiobenzyl linker in the presence of reducing agents to release active substance Mitomycin C. JNJ-27548547 is formulated into pegylated liposomes (PL-MLP) with high antitumor activity in mice models .

HY-D3007

LD-CK	Fluorescent Dye	Others
LD-CK is a fluorescent probe based on a coumarin-chromone structure, specifically designed to visualize lipid droplet polarity changes and endowed with multimodal imaging capability. LD-CK contains a high-performance lipophilic coumarin moiety, which enables it to specifically target lipid droplets upon cellular entry while minimizing background fluorescence to the greatest extent. LD-CK has an excitation wavelength (Ex) of 488 nm and an emission wavelength (Em) of 540 nm (in low-polarity environments such as toluene) or 640 nm (in high-polarity environments such as glycerol), with its emission peak undergoing a redshift as solvent polarity increases .

HY-182267

Antibiofilm agent-20	Bacterial Interleukin Related TNF Receptor	Infection Inflammation/Immunology
Antibiofilm agent-20 is an orally active Escherichia coli biofilm inhibitor (IC₅₀ = 5.5 μg/mL) and show low antibacterial activity (MIC >128 μg/mL). Antibiofilm agent-20 exhibits high lipophilicity and low solubility, resulting in low colon delivery rate. Antibiofilm agent-20 demonstrates anti-inflammatory and reduces IL-17 and TNF-α levels. Antibiofilm agent-20 can be used for the research of inflammatory bowel disease .

HY-183665

GBR-13119	Dopamine Receptor	Neurological Disease
GBR-13119 is a blood-brain barrier-permeable inhibitor of the presynaptic dopamine uptake system. GBR-13119 binds to dopamine uptake sites with high selectivity, without being affected by other neurotransmitter reuptake inhibitors. GBR-13119 exhibits a lipophilic systemic distribution profile with extremely low defluorination in rats, while it shows a differential characteristic of slow striatal washout in the brain of primates. GBR-13119 can serve as a PET tracer to achieve visualized imaging of the striatum in primates, and can reflect MPTP-induced dopaminergic neuron degeneration through reduced uptake. GBR-13119 can be widely applied to studies related to Parkinson's disease and dopaminergic neuron degeneration .

HY-183921

SQ 32547	Calcium Channel	Cardiovascular Disease Inflammation/Immunology
SQ 32547 is a dihydropyridine calcium channel inhibitor with antihypertensive and anti-ischemic activities. SQ 32547 modulates sarcolemmal voltage-dependent calcium channels to inhibit calcium influx, and exerts direct anti-ischemic activity by suppressing myocardial contracture formation and reducing lactate dehydrogenase (LDH) release. SQ 32547 can be used in research related to hypertension, angina pectoris and neurogenic inflammation .

Cat. No.	Product Name

HY-L936V0

Molecular Glue Virtual Library	11412 compounds
Molecular Glue Virtual Library is constructed using generative AI technology, integrating the structural features, activity data of known molecular glues, and interaction information of ternary complexes (target protein-E3-molecular glue). Endowed with structural novelty, drug-likeness, diversity and synthesizability, it is applicable to molecular glue-based AI drug screening and large-scale virtual screening. MCE builds this library based on high-quality molecular building blocks by virtue of robust computing power, coupled with rigorous reaction rules and optimized compound generation strategies. To ensure library quality, molecules with high synthetic difficulty, poor drug-likeness, PAINS and other undesirable molecules are excluded first. Subsequently, scaffold-based compound analysis is performed to screen drug-like diverse molecules for synthesizability evaluation; those with excessively high synthetic difficulty are removed, ultimately forming a large-scale molecular glue virtual library with structural diversity, synthesizability and drug-likeness. Compounds in the library can be synthesized in only 1-2 chemical reaction steps. With MCE’s experienced chemical synthesis team, custom synthesis of different scales from milligram to kilogram can be easily achieved to meet diverse customer needs.

Molecular Glue Virtual Library

11412 compounds

Molecular Glue Virtual Library is constructed using generative AI technology, integrating the structural features, activity data of known molecular glues, and interaction information of ternary complexes (target protein-E3-molecular glue). Endowed with structural novelty, drug-likeness, diversity and synthesizability, it is applicable to molecular glue-based AI drug screening and large-scale virtual screening.

MCE builds this library based on high-quality molecular building blocks by virtue of robust computing power, coupled with rigorous reaction rules and optimized compound generation strategies. To ensure library quality, molecules with high synthetic difficulty, poor drug-likeness, PAINS and other undesirable molecules are excluded first. Subsequently, scaffold-based compound analysis is performed to screen drug-like diverse molecules for synthesizability evaluation; those with excessively high synthetic difficulty are removed, ultimately forming a large-scale molecular glue virtual library with structural diversity, synthesizability and drug-likeness.

Compounds in the library can be synthesized in only 1-2 chemical reaction steps. With MCE’s experienced chemical synthesis team, custom synthesis of different scales from milligram to kilogram can be easily achieved to meet diverse customer needs.

HY-L912V0

MegaUni 10M Virtual Diversity Library	10,000,000 compounds
With MCE's 40,662 BBs, covering around 273 reaction types, more than 40 million molecules were generated. Compounds which comply with Ro5 criteria were selected. Inappropriate chemical structures, such as PAINS motifs and synthetically difficult accessible, were removed. Based on Morgan Fingerprint, molecular clustering analysis was carried out, and molecules close to each clustering center were extracted to form this drug-like and synthesizable diversity library. These selected molecules have 805,822 unique Bemis-Murcko Scaffolds (BMS) with diversified chemical space. This library is highly recommended for AI-based lead discovery, ultra-large virtual screening and novel lead discovery.

MegaUni 10M Virtual Diversity Library

10,000,000 compounds

With MCE's 40,662 BBs, covering around 273 reaction types, more than 40 million molecules were generated. Compounds which comply with Ro5 criteria were selected. Inappropriate chemical structures, such as PAINS motifs and synthetically difficult accessible, were removed. Based on Morgan Fingerprint, molecular clustering analysis was carried out, and molecules close to each clustering center were extracted to form this drug-like and synthesizable diversity library. These selected molecules have 805,822 unique Bemis-Murcko Scaffolds (BMS) with diversified chemical space. This library is highly recommended for AI-based lead discovery, ultra-large virtual screening and novel lead discovery.

HY-L912V

MegaUni 10M Virtual Diversity Library	10,000,000 compounds
With MCE's 40,662 BBs, covering around 273 reaction types, more than 40 million molecules were generated. Compounds which comply with Ro5 criteria were selected. Inappropriate chemical structures, such as PAINS motifs and synthetically difficult accessible, were removed. Based on Morgan Fingerprint, molecular clustering analysis was carried out, and molecules close to each clustering center were extracted to form this drug-like and synthesizable diversity library. These selected molecules have 805,822 unique Bemis-Murcko Scaffolds (BMS) with diversified chemical space. This library is highly recommended for AI-based lead discovery, ultra-large virtual screening and novel lead discovery.

MegaUni 10M Virtual Diversity Library

10,000,000 compounds

HY-L910V

MegaUni 50K Virtual Diversity Library	50,000 compounds
MegaUni 50K Virtual Diversity Library consists of 50,000 novel, synthetically accessible, lead-like compounds. With MCE's 40,662 Building Blocks, covering around 273 reaction types, more than 40 million molecules were generated. Based on Morgan Fingerprint and Tanimoto Coefficient, molecular clustering analysis was carried out, and molecules closest to each clustering center were extracted to form a drug-like and synthesizable diversity library. The selected 50,000 drug-like molecules have 46,744 unique Bemis-Murcko Scaffolds (BMS), each containing only 1-3 compounds. This diverse library is highly recommended for virtual screening and novel lead discovery.

MegaUni 50K Virtual Diversity Library

50,000 compounds

MegaUni 50K Virtual Diversity Library consists of 50,000 novel, synthetically accessible, lead-like compounds. With MCE's 40,662 Building Blocks, covering around 273 reaction types, more than 40 million molecules were generated. Based on Morgan Fingerprint and Tanimoto Coefficient, molecular clustering analysis was carried out, and molecules closest to each clustering center were extracted to form a drug-like and synthesizable diversity library. The selected 50,000 drug-like molecules have 46,744 unique Bemis-Murcko Scaffolds (BMS), each containing only 1-3 compounds. This diverse library is highly recommended for virtual screening and novel lead discovery.

Cat. No.	Product Name	Type

HY-D3007

LD-CK	Fluorescent Dyes
LD-CK is a fluorescent probe based on a coumarin-chromone structure, specifically designed to visualize lipid droplet polarity changes and endowed with multimodal imaging capability. LD-CK contains a high-performance lipophilic coumarin moiety, which enables it to specifically target lipid droplets upon cellular entry while minimizing background fluorescence to the greatest extent. LD-CK has an excitation wavelength (Ex) of 488 nm and an emission wavelength (Em) of 540 nm (in low-polarity environments such as toluene) or 640 nm (in high-polarity environments such as glycerol), with its emission peak undergoing a redshift as solvent polarity increases .

LD-CK

Fluorescent Dyes

LD-CK is a fluorescent probe based on a coumarin-chromone structure, specifically designed to visualize lipid droplet polarity changes and endowed with multimodal imaging capability. LD-CK contains a high-performance lipophilic coumarin moiety, which enables it to specifically target lipid droplets upon cellular entry while minimizing background fluorescence to the greatest extent. LD-CK has an excitation wavelength (Ex) of 488 nm and an emission wavelength (Em) of 540 nm (in low-polarity environments such as toluene) or 640 nm (in high-polarity environments such as glycerol), with its emission peak undergoing a redshift as solvent polarity increases .

Cat. No.	Product Name	Type

HY-125139

omega-3 Arachidonic acid ethyl ester, in ethanol, 98%

ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%

Biochemical Assay Reagents

omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

HY-157915

HFPB Tetrakis[3,5-bis(1,1,1,3,3,3-hexafluoro-2-methoxy-2-propyl)phenyl]borate, sodium salt, trihydrate	Biochemical Assay Reagents
HFPB (Compound 2) is a type of cation exchanger with high lipophilicity and acid resistivity, which can be used in membrane electrode research .

HY-W250129

2,3,4,5-Tetrafluorobenzoyl chloride

Biochemical Assay Reagents

2,3,4,5-Tetrafluorobenzoyl chloride is a fluorinated organic compound that belongs to the class of benzoyl chlorides. It is a colorless liquid with a pungent smell and is mainly used as an intermediate in the synthesis of various pharmaceutical and pesticide compounds. 2,3,4,5-Tetrafluorobenzoyl chloride is an acylating agent that can react with a variety of nucleophiles, including amines, alcohols, and thiols, to form amides, esters, or thioesters, respectively. Its unique fluorine-containing structure can impart desired properties to target molecules, such as increased lipophilicity or increased stability against metabolic degradation. However, due to its high reactivity and potential health hazards, proper safety measures and handling procedures must be followed when using this compound.

HY-W504836

Deuteroporphyrin IX dihydrochloride	Biochemical Assay Reagents
Deuteroporphyrin IX (dihydrochloride) is a photosensitizer with high lipophilicity and amphiphilicity, capable of providing photosensitivity for cell membrane systems. Deuteroporphyrin IX (dihydrochloride) can induce irreversible discharge elimination in individual neurons .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2427

Adamantane	Structural Classification Natural Products Classification of Application Fields Psidium guajava Linn. Other Diseases Myrtaceae Plants Disease Research Fields	Others
Adamantane is a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be studied in pharmacological research to improve the lipophilicity and pharmacological properties of other active products .

HY-A0116A

Trandolaprilate hydrate Trandolaprilat hydrate; RU 44403 hydrate	Cardiovascular Disease Alkaloids Pyrrole Alkaloids Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Trandolaprilate hydrate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate hydrate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity .

HY-A0116

Trandolaprilate Trandolaprilat; RU 44403	Cardiovascular Disease Alkaloids Pyrrole Alkaloids Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity .

HY-A0116R

Trandolaprilate (Standard) Trandolaprilat (Standard); RU 44403 (Standard)	Structural Classification Alkaloids Pyrrole Alkaloids Endogenous metabolite Source Classification	Reference Standards Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Trandolaprilate (Standard) is the analytical standard of Trandolaprilate. This product is intended for research and analytical applications. Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity .

HY-N2427R

Adamantane (Standard)	Natural Products Minerals Plants	Reference Standards Others
Adamantane (Standard) is the analytical standard of Adamantane. This product is intended for research and analytical applications. Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .

Cat. No.	Product Name	Chemical Structure

HY-N2427S

Adamantane-d16
Adamantane-d₁₆is the deuterium labeled Adamantane (HY-N2427). Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .

HY-B0007S2

Baclofen-d5 hydrochloride

Baclofen-d₅ hydrochloride is deuterated labeled Baclofen (HY-B0007). Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABA_B receptor (GABA_BR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABA_B receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research .

HY-A0116S1

Trandolaprilate-d6
Trandolaprilate-d₆ is the deuterium labeled Trandolaprilate . Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity .

HY-W714767

Octisalate-d4
Octisalate-d₄ (Octyl salicylate-d₄; 2-Ethylhexyl salicylate-d₄) is the deuterium labeled Octisalate (HY-B0929). Octisalate (Octyl salicylate) is an organic compound with high lipophilicity, which is used in sunscreens and cosmetics that absorbs UVB rays .

HY-B0007S

Baclofen-d4

Baclofen-d₄ is the deuterium labeled Baclofen. Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research .

HY-W707498

Baclofen-d4-1

Baclofen-d₄-1 is the deuterium labeled Baclofen (HY-B0007). Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research .

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