2. Anti-infection Immunology/Inflammation Apoptosis
  3. Bacterial Interleukin Related TNF Receptor
  4. Antibiofilm agent-20

Antibiofilm agent-20 is an orally active Escherichia coli biofilm inhibitor (IC50 = 5.5 μg/mL) and show low antibacterial activity (MIC >128 μg/mL). Antibiofilm agent-20 exhibits high lipophilicity and low solubility, resulting in low colon delivery rate. Antibiofilm agent-20 demonstrates anti-inflammatory and reduces IL-17 and TNF-α levels. Antibiofilm agent-20 can be used for the research of inflammatory bowel disease.

For research use only. We do not sell to patients.

Antibiofilm agent-20

Antibiofilm agent-20 Chemical Structure

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Antibiofilm agent-20 Related Antibodies

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Description

Antibiofilm agent-20 is an orally active Escherichia coli biofilm inhibitor (IC50 = 5.5 μg/mL) and show low antibacterial activity (MIC >128 μg/mL). Antibiofilm agent-20 exhibits high lipophilicity and low solubility, resulting in low colon delivery rate. Antibiofilm agent-20 demonstrates anti-inflammatory and reduces IL-17 and TNF-α levels. Antibiofilm agent-20 can be used for the research of inflammatory bowel disease[1].

In Vitro

Antibiofilm agent-20 (Compound 1) potently inhibits in vitro Escherichia coli biofilm formation with an IC50 of 5.5 μg/mL and MIC >128 μg/mL[1].
Antibiofilm agent-20 has high membrane permeability, measuring 10.3 × 10-6 cm/s at pH 5.5 and 17.4 × 10-6 cm/s at pH 7.4 in a PAMPA assay[1].
Antibiofilm agent-20 (0.5 mg/mL; 30 min) has no metabolic stability in mouse liver microsomes, with 0% of the compound remaining after 30 min of incubation at 0.5 mg/mL protein concentration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibiofilm agent-20 Related Antibodies
Parmacokinetics
Species Dose Route C0 T1/2 AUCinf Vdss Tmax Cmax AUCall Bioavailability
Mice[1] 100 mg/kg p.o. / / / / 0.500 h 0.326 μg/mL 1.10 μg·h/mL 15.5 %
Mice[1] 30 mg/kg p.o. / / / / 3.00 h 0.0893 μg/mL 0.297 μg·h/mL 0.682 %
Mice[1] 1 mg/kg i.v. 0.159 μg/mL 1.43 h 0.0724 μg·h/mL 21.1 L/kg / / / /
Mice[1] 1 mg/kg i.v. 15.2 μg/mL 1.26 h 1.45 μg·h/mL 0.106 L/kg / / / /
In Vivo

Antibiofilm agent-20 (Compound 1) (100 mg/kg; p.o.; daily for 7 days) demonstrates anti-inflammatory and disease-modifying activity in a mouse DSS (HY-116282C)-induced colitis model, with 100 mg/kg oral administration significantly increasing colon length and reducing pro-inflammatory cytokine levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 with DSS-induced colitis model (treatment group n=8)[1]
Dosage: 100 mg/kg
Administration: p.o.
Result: Increased mean colon length.
Reduced mean colon tissue IL-17 levels.
Reduced mean colon tissue TNF-α levels.
Molecular Weight

412.01

Formula

C25H34ClN3
SMILES

CCCCC1=CC=C(C=C1)CNC2=NC=CN2CC3=CC=C(C=C3)CCCC.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antibiofilm agent-20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibiofilm agent-20Antibiofilm agent20Antibiofilm agent 20BacterialInterleukin RelatedTNF ReceptorILTumor Necrosis Factor ReceptorTNFREscherichia colibiofilmmouse liver microsomesmouse DSS-induced colitis modelinflammatory bowel diseasepro-inflammatory cytokineInhibitorinhibitorinhibit

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