Antibiofilm agent-20
Antibiofilm agent-20 is an orally active Escherichia coli biofilm inhibitor (IC50 = 5.5 μg/mL) and show low antibacterial activity (MIC >128 μg/mL). Antibiofilm agent-20 exhibits high lipophilicity and low solubility, resulting in low colon delivery rate. Antibiofilm agent-20 demonstrates anti-inflammatory and reduces IL-17 and TNF-α levels. Antibiofilm agent-20 can be used for the research of inflammatory bowel disease.
For research use only. We do not sell to patients.
- Formula: C25H34ClN3
- Molecular Weight:412.01
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antibiofilm agent-20 (Compound 1) potently inhibits in vitro Escherichia coli biofilm formation with an IC50 of 5.5 μg/mL and MIC >128 μg/mL[1].
Antibiofilm agent-20 has high membrane permeability, measuring 10.3 × 10-6 cm/s at pH 5.5 and 17.4 × 10-6 cm/s at pH 7.4 in a PAMPA assay[1].
Antibiofilm agent-20 (0.5 mg/mL; 30 min) has no metabolic stability in mouse liver microsomes, with 0% of the compound remaining after 30 min of incubation at 0.5 mg/mL protein concentration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | C0 | T1/2 | AUCinf | Vdss | Tmax | Cmax | AUCall | Bioavailability |
|---|---|---|---|---|---|---|---|---|---|---|
| Mice[1] | 100 mg/kg | p.o. | / | / | / | / | 0.500 h | 0.326 μg/mL | 1.10 μg·h/mL | 15.5 % |
| Mice[1] | 30 mg/kg | p.o. | / | / | / | / | 3.00 h | 0.0893 μg/mL | 0.297 μg·h/mL | 0.682 % |
| Mice[1] | 1 mg/kg | i.v. | 0.159 μg/mL | 1.43 h | 0.0724 μg·h/mL | 21.1 L/kg | / | / | / | / |
| Mice[1] | 1 mg/kg | i.v. | 15.2 μg/mL | 1.26 h | 1.45 μg·h/mL | 0.106 L/kg | / | / | / | / |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 with DSS-induced colitis model (treatment group n=8)[1]
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Dosage:100 mg/kg
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Administration:p.o.
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Result:Increased mean colon length.
Reduced mean colon tissue IL-17 levels.
Reduced mean colon tissue TNF-α levels.
Chemical Information
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Molecular Weight 412.01
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Formula C25H34ClN3
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SMILES
CCCCC1=CC=C(C=C1)CNC2=NC=CN2CC3=CC=C(C=C3)CCCC.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibiofilm agent-20 Related Classifications
HY-182267 Related Classifications
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