1. Metabolic Enzyme/Protease
  2. CETP
  3. CP-532623

CP-532623 

Cat. No.: HY-123039 Purity: >99.0%
Handling Instructions

CP-532623 is a CETP inhibitor and elevates high-density lipoprotein cholesterolion. CP-532623 is a close structural analogue of Torcetrapib. CP-532623 has highly lipophilic properties.

For research use only. We do not sell to patients.

CP-532623 Chemical Structure

CP-532623 Chemical Structure

CAS No. : 261947-38-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 481 In-stock
Estimated Time of Arrival: December 31
5 mg USD 365 In-stock
Estimated Time of Arrival: December 31
10 mg USD 615 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CP-532623 is a CETP inhibitor and elevates high-density lipoprotein cholesterolion. CP-532623 is a close structural analogue of Torcetrapib. CP-532623 has highly lipophilic properties[1][2][3].

IC50 & Target

CETP[1]

In Vitro

CP-532623 is highly lymphatically transported (28% of dose), and lymphatic transport is closely correlated with drug affinity for ex-vivo lymph lipoproteins or triglyceride emulsions and poorly relates to solubility in mixtures of lipoprotein core and/or surface lipids. CP-532623 alters the kinetics of lymph lipid transport and decreases lymph lipid transport in chylomicrons[2].

In Vivo

CP-532623 (50 mg; oral administration; adult male greyhound dogs) treatment substantially transports into the lymphatic system (>25% dose) in fed and fasted dogs. Food enhances oral bioavailability (from 44 to 58%, respectively) and the proportion of the absorbed dose transports via the lymph (from 61 to 86% and from 68 to 83%, respectively). Lymphatic triglyceride transport is significantly lower in fed dogs administered CP-532623[3].

Animal Model: Adult male greyhound dogs (27-39 kg)[3]
Dosage: 50 mg
Administration: Oral administration with a long-chain lipid formulation to fed lymphcannulated
Result: Substantially transported into the lymphatic system (>25% dose) in fed and fasted dogs. Food enhanced oral bioavailability and the proportion of the absorbed dose transported via the lymph.
Molecular Weight

598.50

Formula

C₂₇H₂₇F₉N₂O₃

CAS No.

261947-38-0

SMILES

O=C(N1[[email protected]](CC)C[[email protected]](N(C(C)=O)CC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C3=C1C=CC(C(F)(F)F)=C3)OC(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

CP-532623CP532623CP 532623CETPCholesteryl ester transfer proteinLymphaticallylipoproteinstriglyceridelipophilicHDL-CTorcetrapiboralbioavailabilityInhibitorinhibitorinhibit

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CP-532623
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HY-123039
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