261947-38-0
261947-38-0
Chemical Structure
CP-532623
- CAS No.: 261947-38-0
- Formula:C27H27F9N2O3
- Molecular Weight:598.50
IUPAC Name: isopropyl (2R,4S)-4-(N-(3,5-bis(trifluoromethyl)benzyl)acetamido)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
InChIKey: TUPKOWFPVAXQFP-OFNKIYASSA-N
SMILES: O=C(N1[C@H](CC)C[C@H](N(C(C)=O)CC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C3=C1C=CC(C(F)(F)F)=C3)OC(C)C
Biological Activity: CP-532623 is a CETP inhibitor and elevates high-density lipoprotein cholesterolion. CP-532623 is a close structural analogue of Torcetrapib. CP-532623 has highly lipophilic properties[1][2][3].
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CP-532623 | CP-532623 is a CETP inhibitor and elevates high-density lipoprotein cholesterolion. CP-532623 is a close structural analogue of Torcetrapib. CP-532623 has highly lipophilic properties. | |||||||||||||||||||||
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References
- [1]. Blasi E, et al. Effects of CP-532,623 and torcetrapib, cholesteryl ester transfer protein inhibitors, on arterial blood pressure. J Cardiovasc Pharmacol. 2009 Jun;53(6):507-16. [Content Brief]
- [2]. Trevaskis NL, et al. The mechanism of lymphatic access of two cholesteryl ester transfer protein inhibitors (CP524,515 and CP532,623) and evaluation of their impact on lymph lipoprotein profiles. Pharm Res. 2010 Sep;27(9):1949-64. [Content Brief]
- [3]. Trevaskis NL, et al. The role of the intestinal lymphatics in the absorption of two highly lipophilic cholesterol ester transfer protein inhibitors (CP524,515 and CP532,623). Pharm Res. 2010 May;27(5):878-93. [Content Brief]
