Bisbentiamine

Cat. No.: HY-133844 Purity: 99.52%: Data Sheet
COA

SDS
Handling Instructions
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Bisbentiamine is a lipophilic thiamine prodrug with pH-dependent solubility. The bioavailability of Bisbentiamine is regulated by diet type, administration time, gastric acidity, and formulation.

For research use only. We do not sell to patients.

Bisbentiamine Chemical Structure

CAS No. : 2667-89-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Description

Bisbentiamine is a lipophilic thiamine prodrug with pH-dependent solubility. The bioavailability of Bisbentiamine is regulated by diet type, administration time, gastric acidity, and formulation^[1].

In Vitro

Bisbentiamine exhibits pH-dependent solubility: it dissolves readily in acidic environments but is poorly soluble in neutral pH conditions, and is classified as a dissolution rate-controlled compound^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

770.92

Formula

C₃₈H₄₂N₈O₆S₂

CAS No.

2667-89-2

Appearance

Solid

Color

White to off-white

SMILES

O=CN(CC1=CN=C(C)N=C1N)/C(C)=C(SS/C(CCOC(C2=CC=CC=C2)=O)=C(N(CC3=CN=C(C)N=C3N)C=O)/C)/CCOC(C4=CC=CC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (129.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2972 mL	6.4858 mL	12.9715 mL
5 mM	0.2594 mL	1.2972 mL	2.5943 mL
10 mM	0.1297 mL	0.6486 mL	1.2972 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.52%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (253 KB) HNMR (309 KB) LCMS (338 KB)

Handling Instructions (2659 KB)

References

[1]. Mizobe M, et al. Studies on the evaluation of bioavailability of oral solid formulation. V. Effects of diets on the bioavailability of bisbentiamine experimental tablets and their relation to physiological and formulation factors. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan, 1982, 102(12): 1162-1170.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2972 mL	6.4858 mL	12.9715 mL	32.4288 mL
	5 mM	0.2594 mL	1.2972 mL	2.5943 mL	6.4858 mL
	10 mM	0.1297 mL	0.6486 mL	1.2972 mL	3.2429 mL
	15 mM	0.0865 mL	0.4324 mL	0.8648 mL	2.1619 mL
	20 mM	0.0649 mL	0.3243 mL	0.6486 mL	1.6214 mL
	25 mM	0.0519 mL	0.2594 mL	0.5189 mL	1.2972 mL
	30 mM	0.0432 mL	0.2162 mL	0.4324 mL	1.0810 mL
	40 mM	0.0324 mL	0.1621 mL	0.3243 mL	0.8107 mL
	50 mM	0.0259 mL	0.1297 mL	0.2594 mL	0.6486 mL
	60 mM	0.0216 mL	0.1081 mL	0.2162 mL	0.5405 mL
	80 mM	0.0162 mL	0.0811 mL	0.1621 mL	0.4054 mL
	100 mM	0.0130 mL	0.0649 mL	0.1297 mL	0.3243 mL

Bisbentiamine Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bisbentiamine2667-89-2Drug IntermediateDrug Iintermediatehigh fat dietscalcium citratebioavailabilityformulationthiamine prodruglipophilicpH-dependent solubilitygastric acidityhigh protein dietsdiet typeInhibitorinhibitorinhibit

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Bisbentiamine

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