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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
human IDO1
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "human IDO1" in MCE Product Catalog:
2
Cat. No.: HY-RS06539
Target:
Research Areas:
IDO1 Human Pre-designed siRNA Set A contains three designed siRNAs for IDO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W113615
CAS No.: 1680-44-0
Research Areas:
4-Phenyl-1H-1,2,3-triazole is a selective IDO1 inhibitor with an IC50 of 83 μM against human IDO1. 4-Phenyl-1H-1,2,3-triazole binds to the heme iron of IDO1 and occupies its active site, thereby inhibiting tryptophan catabolism. 4-Phenyl-1H-1,2,3-triazole can serve as a precursor for the synthesis of HIV-1 capsid protein inhibitors. 4-Phenyl-1H-1,2,3-triazole is applicable to research related to cancer and organic synthesis .
Cat. No.: HY-173066
CAS No.: 3048196-52-4
Research Areas:
NU227326 is a blood-brain barrier penetrant IDO1 PROTAC degrader, with a DC50 of 4.5 nM in HiBiT degradation assays. NU227326 degrades IDO1 in U87 and GBM43 cells, with DC50 values of 7.1 nM and 11.8 nM, respectively (WB assays). NU227326 is applicable to research related to glioblastoma, prostate cancer, triple-negative breast cancer, pancreatic cancer, and ovarian cancer .
Cat. No.: HY-156400
CAS No.: 3007671-44-2
Research Areas:
IDO1-IN-23 (compound 41) is a potent human IDO1 inhibitor with an IC50 value of 13 μM .
Cat. No.: HY-184104
CAS No.: 537010-02-9
Research Areas:
IDO1/TDO-IN-17 is an IDO1/TDO inhibitor with human IDO1 IC50 ~280 μmol/L and human TDO IC50 204 μmol/L. IDO1/TDO-IN-17 binds to the heme-iron of IDO1. IDO1/TDO-IN-17 can be used for the research of cancer .
Cat. No.: HY-184135
CAS No.: 1918946-83-4
Research Areas:
IDO1/TDO-IN-2 is an IDO1/TDO inhibitor with both human IDO1 and human TDO pIC50 ≥5.50. IDO1/TDO-IN-2 can be used for the research of cancer .
Cat. No.: HY-187530
Research Areas:
IDO1/TDO-IN-18 is a IDO1/TDO inhibitor with an IC50 of 26.54 μM against human IDO1 and an IC50 of 15.63 μM against human TDO. IDO1/TDO-IN-18 targets the apo-forms of IDO1 and TDO to displace the heme cofactor, attenuates the IDO1/SHP-2 interaction, reduces the output of the kynurenine pathway in tumor cells, and inhibits the proliferation and migration of cancer cells. IDO1/TDO-IN-18 can serve as a chemical probe for enzymology and signal transduction-related studies of the IDO1/TDO axis, and can also be used in cancer-related research .
Cat. No.: HY-N0353R
CAS No.: 13657-68-6
Synonyms: (+)-Curdione (Standard)
Cat. No.: HY-P70679
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IDO1; Indoleamine-Pyrrole 2,3-Dioxygenase; Prev. INDO; Indolamine 2,3 Dioxygenase; Prev. IDO; Indole 2,3-Dioxygenase; IDO-1; Indoleamine 2,3-Dioxygenase 1; Indoleamine-Pyrrole 2,3 Dioxygenase
Cat. No.: HY-W1060365
CAS No.: 2089-12-5
Research Areas:
4-((Aminooxy)methyl)phenol is an Indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor with a human IC50 of 61 μM. 4-((Aminooxy)methyl)phenol inhibits IDO1 catalytic activity and acts as a structural mimic of the enzyme's alkylperoxy transition or intermediate state. 4-((Aminooxy)methyl)phenol can be used for the research of cancer .
Cat. No.: HY-148336A
Research Areas:
IDO1/TDO-IN-5 (compound 9p-O) is a potent dual IDO1/TDO inhibitor with IC50 valeus of 18 and 25 nM, respectively .
Cat. No.: HY-148336
CAS No.: 2407753-09-5
Target:
Research Areas:
(E)-IDO1/TDO-IN-5 is the E configuration of IDO1/TDO-IN-5 (HY-148336A). IDO1/TDO-IN-5 is a dual IDO1/TDO inhibitor with IC50 values of 0.018 and 0.025 μM, respectively .
Cat. No.: HY-184028
CAS No.: 3117126-69-6
Research Areas:
IDO1/TDO-IN-13 (Compound 40) is a selective, non-competitive IDO1 inhibitor with an IC50 of 0.106 μM against IDO1. IDO1/TDO-IN-13 is applicable to the research of inflammatory diseases .
Cat. No.: HY-184134
CAS No.: 2351846-94-9
Research Areas:
IDO1/TDO-IN-16 (Fig.1 Compound 4) is a dual inhibitor of IDO1 and TDO. IDO1/TDO-IN-16 is applicable for cancer research .
Cat. No.: HY-184077
CAS No.: 2701898-79-3
Research Areas:
IDO1-IN-35 is an inhibitor of the IDO1 mutant IDO1 F164A. IDO1-IN-35 inhibits the IDO1-mediated conversion of L-tryptophan to N-formyl-L-kynurenine. IDO1-IN-35 can be used in studies of viral and bacterial infections .
Cat. No.: HY-W1011921
CAS No.: 2227460-99-1
Research Areas:
TDO2-IN-3 is a selective TDO2 inhibitor with an IC50 of 0.34 μM. TDO2-IN-3 can be used in cancer-related research .
Cat. No.: HY-184105
CAS No.: 2131827-12-6
Research Areas:
IDO1-IN-36 is a selective, mixed-type IDO1 inhibitor with an IC50 of 0.72 μM against hIDO1. IDO1-IN-36 exhibits extremely low cytotoxicity in cancer cells. IDO1-IN-36 can be used for the research of breast cancer .
Cat. No.: HY-181947
Research Areas:
IDO1-IN-33 (Compound YC-16) is a IDO1 inhibitor (with an IC50 of 0.18 μM for IDO1 in HeLa cells). IDO1-IN-33 acts as an apo-IDO1 inhibitor by slowly and competitively displacing heme from mature holo-IDO1 and rapidly binding to the heme-binding site of immature apo-IDO1, without altering the expression level of IDO1. IDO1-IN-33 can be used for the research of hepatocellular carcinoma, non-small cell lung cancer, triple-negative breast cancer, and cervical cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
