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Cat. No.: HY-184077

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IDO1-IN-35

IDO1-IN-35 is an inhibitor of the IDO1 mutant IDO1^F164A. IDO1-IN-35 inhibits the IDO1-mediated conversion of L-tryptophan to N-formyl-L-kynurenine. IDO1-IN-35 can be used in studies of viral and bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 2701898-79-3
Formula: C₁₂H₁₃ClN₂O₂
Molecular Weight:252.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IDO1-IN-35 Chemical Structure

CAS No.: 2701898-79-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
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Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

IDO1

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms :

In Vitro

IDO1-IN-35 (compound 16) (100 μM-1 mM; 15 min pre-incubation) inhibits recombinant human IDO1^F164A-mediated L-tryptophan metabolism at 1 mM but shows no inhibition at 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2701898-79-3
Molecular Weight 252.70
Formula C₁₂H₁₃ClN₂O₂
SMILES

O=C(C1(CC1C2=CNC3=C2C=CC=C3)N)O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cundy NJ, et al. Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity. RSC Chem Biol. 2021;2(6):1651-1660. Published 2021 Sep 13. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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IDO1-IN-35

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

IDO1-IN-35 Related Classifications

HY-184077 Related Classifications