IDO1-IN-36
IDO1-IN-36 is a selective, mixed-type IDO1 inhibitor with an IC50 of 0.72 μM against hIDO1. IDO1-IN-36 exhibits extremely low cytotoxicity in cancer cells. IDO1-IN-36 can be used for the research of breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 2131827-12-6
- Formula: C14H12N4O
- Molecular Weight:252.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hIDO1 0.72 μM (IC50) |
IDO1-IN-36 (Compound 5a) (10 μM) inhibits purified hIDO1 enzyme, with an IC50 of 0.72 μM and an inhibition rate of 98% at a concentration of 10 μM[1].
IDO1-IN-36 inhibits IFN-γ-induced IDO1 activity in MDA-MB-231 breast cancer cells, with an EC50 of 381 nM[1].
IDO1-IN-36 exhibits 17-fold higher selectivity for purified hIDO1 over purified hTDO, with an IC50 of 12.3 μM against TDO[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2131827-12-6
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Molecular Weight 252.27
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Formula C14H12N4O
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SMILES
O=C(C1=NNC2=C1C=CC=C2)NNC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IDO1-IN-36 Related Classifications
HY-184105 Related Classifications
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