IDO1-IN-36 

IDO1-IN-36 (Compound 5a) is a selective, mixed-type IDO1 inhibitor with an IC₅₀ of 0.72 μM against hIDO1. IDO1-IN-36 exhibits extremely low cytotoxicity in cancer cells. IDO1-IN-36 can be used for the research of breast cancer^[1].

IDO1-IN-36 (10 μM) inhibits purified hIDO1 enzyme, with an IC₅₀ of 0.72 μM and an inhibition rate of 98% at a concentration of 10 μM^[1].
IDO1-IN-36 inhibits IFN-γ-induced IDO1 activity in MDA-MB-231 breast cancer cells, with an EC₅₀ of 381 nM^[1].
IDO1-IN-36 exhibits 17-fold higher selectivity for purified hIDO1 over purified hTDO, with an IC₅₀ of 12.3 μM against TDO^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

252.27

C₁₄H₁₂N₄O

2131827-12-6

O=C(C1=NNC2=C1C=CC=C2)NNC3=CC=CC=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pradhan N, et al. Identification of Substituted 1H‐Indazoles as Potent Inhibitors for Immunosuppressive Enzyme Indoleamine 2, 3‐Dioxygenase 1[J]. ChemistrySelect, 2017, 2(20): 5511-5517.