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Cat. No.: HY-184134

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IDO1/TDO-IN-16

IDO1/TDO-IN-16 (Fig.1 Compound 4) is a dual inhibitor of IDO1 and TDO. IDO1/TDO-IN-16 is applicable for cancer research.

For research use only. We do not sell to patients.

CAS No.: 2351846-94-9
Formula: C₁₄H₁₀BrN₅O
Molecular Weight:344.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IDO1/TDO-IN-16 Chemical Structure

CAS No.: 2351846-94-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

IDO1/TDO-IN-16 (Fig.1 Compound 4) is a dual inhibitor of IDO1 and TDO. IDO1/TDO-IN-16 is applicable for cancer research^[1].

IC₅₀ & Target^[1]

IDO1

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	1.37 μM Compound: 35	Inhibition of IDO1 in IFN-gamma-induced human HeLa cells assessed as reduction in L-kynurenine level after 24 hrs Inhibition of IDO1 in IFN-gamma-induced human HeLa cells assessed as reduction in L-kynurenine level after 24 hrs	[PMID: 30773421]

Chemical Information

CAS No. 2351846-94-9
Molecular Weight 344.17
Formula C₁₄H₁₀BrN₅O
SMILES

BrC1=CC(NCC2=CC=CC3=NON=C32)=C4C=NNC4=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pan S, et al. Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO). Eur J Med Chem. 2020;207:112703. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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IDO1/TDO-IN-16

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

IDO1/TDO-IN-16 Related Classifications

HY-184134 Related Classifications