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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

human breast carcinoma cell lines

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

5

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-119272
    EF24
    2 Publications Verification

    		 ERK Caspase NF-κB Apoptosis p38 MAPK Reactive Oxygen Species (ROS) Inflammation/Immunology Cancer
    EF24, a curcumin analogue, is an NF-kB inhibitor with great anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 is active against melanoma and breast cancer cell lines with GI50 values of 0.7 μM and 0.8 μM, respectively. EF24 induces cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells. EF24 increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK .
    EF24
  • HY-123901
    Garcinone E

    		Apoptosis Cancer
    Garcinone E is a natural xanthone found in the rind of the mangosteen fruit. Garcinone E induces apoptosis and inhibits cancer cell migration. Garcinone E has anticancer effects on different human cancer cell lines, including colorectal, breast, and hepatocellular carcinomas .
    Garcinone E
  • HY-165245
    SBI-183

    		Transmembrane Glycoprotein Cancer
    SBI-183 is an orally active inhibitor of QSOX1 (Kd: 20 μM). SBI-183 suppresses the proliferative and invasive phenotype of renal cancer cell lines, including triple negative breast cancer cell line, lung adenocarcinoma cell line and pancreatic ductal adenocarcinoma. SBI-183 inhibits tumor growth in two human xenograft mouse models of renal cell carcinoma in vivo .
    SBI-183
  • HY-175857
    HDAC-IN-92

    		HDAC Apoptosis Cancer
    HDAC-IN-92 is a pan-HDAC inhibitor with an IC50 of 12.58 µM in A2780 cells. HDAC-IN-92 demonstrates broad-spectrum, notable cytotoxic activity against a range of human cancer cell lines, including ovarian, liver, and breast carcinomas. HDAC-IN-92 causes apoptosis and demonstrates a notable decrease in tumor cell colony formation. HDAC-IN-92 inhibits the formation of blood vessels in the chick chorioallantoic membrane (CAM). HDAC-IN-92 exhibits anti-tumor effect in a 4T1 tumor-bearing mouse model. HDAC-IN-92 can be used for research targeting solid tumor .
    HDAC-IN-92
  • HY-181166
    EGFR-IN-194

    		EGFR Apoptosis Cancer
    EGFR-IN-194 is a potent EGFR tyrosine kinase inhibitor with an IC50 of 54.3 nM against human EGFR. EGFR-IN-194 induces apoptosis, inhibits migration in cancer cells, selectively promotes invasion in cancer cells, and exhibits antiproliferative effects across multiple cancer cell lines. EGFR-IN-194 can be used for the research of prostate adenocarcinoma, non-small cell lung carcinoma, breast carcinoma, chronic myeloid leukemia .
    EGFR-IN-194
  • HY-W727102
    (Z)-8-β-D-Glucopyranosyloxycinnamic acid

    		Others Others
    (Z)-8-β-D-Glucopyranosyloxycinnamic acid is a phenolic glycoside present in the roots of Codonopsis javanica. (Z)-8-β-D-Glucopyranosyloxycinnamic acid exhibits no toxicity against lung cancer, liver cancer and breast cancer cell lines .
    (Z)-8-β-D-Glucopyranosyloxycinnamic acid
  • HY-118713
    Kuanoniamine A

    		DNA/RNA Synthesis Apoptosis Cancer
    Kuanoniamine A is a pyridoacridine alkaloid and also an anticancer agent. Kuanoniamine A inhibits DNA synthesis, induces apoptosis, and regulates the cell cycle by reducing the proportion of cells in the G2/M phase. Kuanoniamine A inhibits the proliferation of human lymphocytes. Kuanoniamine A can be used in research related to breast cancer, glioma, non-small cell lung cancer, and melanoma .
    Kuanoniamine A
  • HY-N19853
    Mangiferonic acid

    		Drug Derivative Cancer
    Mangiferonic acid is a triterpenoid found in the stems of Vatica diospyroides. Mangiferonic acid can be used for cancer research .
    Mangiferonic acid
  • HY-N17074
    Ethyl (10E,12E)-9-oxooctadeca-10,12-dienoate

    		Others Cancer
    Ethyl (10E,12E)-9-oxooctadeca-10,12-dienoate is a conjugated ketonic fatty acid that can be found in the leaves of Vernicia fordii. Ethyl (10E,12E)-9-oxooctadeca-10,12-dienoate shows no significant cytotoxic activity against cancer cells .
    Ethyl (10E,12E)-9-oxooctadeca-10,12-dienoate
  • HY-181947
    IDO1-IN-33

    		Indoleamine 2,3-Dioxygenase (IDO) Cancer
    IDO1-IN-33 (Compound YC-16) is a IDO1 inhibitor (with an IC50 of 0.18 μM for IDO1 in HeLa cells). IDO1-IN-33 acts as an apo-IDO1 inhibitor by slowly and competitively displacing heme from mature holo-IDO1 and rapidly binding to the heme-binding site of immature apo-IDO1, without altering the expression level of IDO1. IDO1-IN-33 can be used for the research of hepatocellular carcinoma, non-small cell lung cancer, triple-negative breast cancer, and cervical cancer .
    IDO1-IN-33

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