HDAC-IN-92
HDAC-IN-92 is a pan-HDAC inhibitor with an IC50 of 12.58 µM in A2780 cells. HDAC-IN-92 demonstrates broad-spectrum, notable cytotoxic activity against a range of human cancer cell lines, including ovarian, liver, and breast carcinomas. HDAC-IN-92 causes apoptosis and demonstrates a notable decrease in tumor cell colony formation. HDAC-IN-92 inhibits the formation of blood vessels in the chick chorioallantoic membrane (CAM). HDAC-IN-92 exhibits anti-tumor effect in a 4T1 tumor-bearing mouse model. HDAC-IN-92 can be used for research targeting solid tumor.
For research use only. We do not sell to patients.
- Formula: C19H17FN4O2S
- Molecular Weight:384.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HDAC-IN-92 (compound 6g) (18 h) demonstrates significant cytotoxicity in a broad panel of cancer cell lines, with IC50s of 22.17 μM (MCF-7), 8.46 μM (HepG2), 8.10 μM (A2780), 26.89 μM (A2780cis), 75.90 μM (HT29), and 14.11 μM (4T1)[1].
HDAC-IN-92 (18 h) demonstrates a correlation between its cytotoxicity against cancer cells and its pan-HDAC inhibitory activity, suggesting that its antitumor effect may be mediated by the inhibition of histone deacetylases[1].
HDAC-IN-92 (8.10 μM, 24 h) significantly promotes apoptosis, increasing the total apoptotic population from 1.82 % to 22.17 %, and inhibits cell migration in A2780 cells[1].
HDAC-IN-92 (22.17 μM, 10 days) remarkably reduces colony formation in MCF-7 cancer cells[1].
HDAC-IN-92 (5 μM, 96 h) inhibits CAM angiogenesis as effectively as Vorinostat (HY-10221), as evidenced by a marked reduction in branching points, tube number, and total tube length[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A2780 cells
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Concentration:8.10 nM
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Incubation Time:24 h
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Result:Increased percentage early and late apoptosis cells from 1.82 % of the control to 22.17 %.
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Cell Line:MCF-7 cells
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Concentration:22.17 nM
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Incubation Time:24 h
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Result:Reduces colony formation in MCF-7 cancer cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Balb/c mice (4-6 weeks old) injected subcutaneously with 4T1 cells[1]
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Dosage:50 mg/kg
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Administration:i.p., every other day for 21 days
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Result:Reduced tumor volume better than Vorinostat.
Exerted no significant effects on the body weight or survival rates of mice.
Induced tumor cell apoptosis without exhibiting toxicity in major organs.
Chemical Information
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Molecular Weight 384.43
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Formula C19H17FN4O2S
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SMILES
O=C(NO)C1=CC=C(/N=C/C2=CN=C(SCC3=CC=CC(F)=C3)N2C)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC-IN-92 Related Classifications
HY-175857 Related Classifications
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