EGFR-IN-194
EGFR-IN-194 is a potent EGFR tyrosine kinase inhibitor with an IC50 of 54.3 nM against human EGFR. EGFR-IN-194 induces apoptosis, inhibits migration in cancer cells, selectively promotes invasion in cancer cells, and exhibits antiproliferative effects across multiple cancer cell lines. EGFR-IN-194 can be used for the research of prostate adenocarcinoma, non-small cell lung carcinoma, breast carcinoma, chronic myeloid leukemia.
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- Fòrmula: C28H29FN4O2S
- Peso molecular:504.62
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
EGFR 54.3 nM (IC50) |
In Vitro
EGFR-IN-194 (compound 24) (1-100 μM; 48 h) potently inhibits proliferation of PC-3, A549, MCF-7, and K562 cancer cells with IC50 values of 3.18 μM, 9.69 μM, 43.51 μM, and 71.18 μM, respectively, while sparing NIH3T3 noncancerous cells[1].
EGFR-IN-194 (5 μM; 24 h for PC-3; 10 μM; 24 h for A549) induces mitochondrial depolarization in PC-3 and A549 cells, and triggeres apoptosis in PC-3 and A549 cells[1].
EGFR-IN-194 (5 μM; up to 48 h for PC-3; 10 μM; up to 48 h for A549) inhibited migration of PC-3 and A549 cells, as shown by reduced wound closure[1].
EGFR-IN-194 (~18 h) promoted invasion of PC-3 cells and inhibited invasion of A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562, PC-3, MCF-7, A549, NIH3T3
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Concentration:1-100 μM
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Incubation Time:48 h
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Result:Inhibited proliferation of K562 cells with an IC50 of 71.18 μM; inhibited proliferation of PC-3 cells with an IC50 of 3.18 μM; inhibited proliferation of MCF-7 cells with an IC50 of 43.51 μM; inhibited proliferation of A549 cells with an IC50 of 9.69 μM; showed minimal cytotoxicity toward NIH3T3 cells with an IC50 > 100 μM.
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Cell Line:PC-3, A549
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Concentration:5 μM (PC-3); 10 μM (A549)
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Incubation Time:24 h (PC-3); 24 h (A549)
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Result:Induced early and late apoptosis in PC-3 cells, characterized by condensed/fragmented nuclei; induced intense nuclear fragmentation and increased late apoptotic cells in A549 cells.
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Cell Line:PC-3, A549
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Concentration:5 μM (PC-3); 10 μM (A549)
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Incubation Time:48 h
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Result:Moderately inhibited PC-3 migration at 24 h and significantly reduced wound closure at 48 h; severely inhibited A549 migration at 48 h compared to controls.
Chemical Information
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Peso molecular 504.62
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Fòrmula C28H29FN4O2S
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SMILES
O=C(NC1=CC=C(F)C=C1)CSC2=NN=C(N2CC3=CC=CC=C3)COC4=C(C(C)C)C=CC(C)=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-194 Related Classifications
HY-181166 Related Classifications
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