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kinesin spindle protein inhibitor

" in MedChemExpress (MCE) Product Catalog:

標的別:	Kinesin (17) ADC Linker (1) ADC Payload (1) Apoptosis (10) Lipoxygenase (1) Mitosis (2) PROTACs (1) Reference Standards (1)
研究分野別:	Cancer (17) Neurological Disease (1)

阻害剤およびアゴニスト

同位体標識化合物

Targets Recommended: Kinesin Mps1

製品番号	製品名	Target	研究分野	構造式

HY-50759

Ispinesib Maximum Cited Publications 7 Publications Verification SB-715992; CK-0238273	Kinesin Apoptosis	Cancer
Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a K_{i app} of 1.7 nM.

HY-15187

Filanesib Maximum Cited Publications 7 Publications Verification ARRY-520	Kinesin Apoptosis	Cancer
Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC₅₀ of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity .

HY-50672

MK-0731	Kinesin Apoptosis Lipoxygenase	Cancer
MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC₅₀ of 2.2 nM and a pK_a of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy .

HY-13224

AZD4877	Kinesin Apoptosis Mitosis	Cancer
AZD4877 is another isostere to Ispinesib (HY-50759)and also a *kinesin* spindle protein (Eg5) inhibitor with IC₅₀ of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity .

HY-15187A

(R)-Filanesib (R)-ARRY-520	Kinesin	Cancer
(R)-Filanesib ((R)-ARRY-520) is the R-enantiomer of Filanesib (HY-15187). Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor with an IC₅₀ of 6 nM.

HY-177285

NVP-BQS481	Kinesin ADC Payload	Cancer
NVP-BQS481 (Compound 1) is a selective Kinesin spindle protein-5 (Eg5) inhibitor with an IC₅₀< 0.5 nM. NVP-BQS481 has significant antimitotic and antitumor activity (IC₅₀: 0.0.9 nM for SK-OV-3ip cells). NVP-BQS481 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .

HY-157338

NHS-Ala-Ala-Asn-active metabolite	ADC Linker Kinesin	Cancer
NHS-Ala-Ala-Asn-active metabolite is a cleavable antibody-drug conjugate (ADC) linker for synthesis of kinesin spindle protein (KSP)inhibitor .

HY-124790

KSP-IA	Kinesin Mitosis	Cancer
KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC₅₀ value of 3.6 nM. KSP-IA inhibits cell mitosis .

HY-15187C

Filanesib hydrochloride Maximum Cited Publications 7 Publications Verification ARRY-520 hydrochloride	Kinesin Apoptosis	Neurological Disease Cancer
Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC₅₀ of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity .

HY-122130

SCH 2047069 MK-8267	Kinesin Apoptosis	Cancer
SCH 2047069 (MK-8267) is an orally active kinesin spindle protein (KSP) inhibitor (K_d: 0.5 nM) that can cross the blood-brain barrier. SCH 2047069 exhibits an IC₅₀ value of ≤ 5 nM against the KSP ATPase. SCH 2047069 exhibits broad-spectrum antitumor activity. SCH 2047069 can induce mitotic arrest and apoptosis in tumor cells. SCH 2047069 can be used in the research of tumors such as ovarian cancer, colon cancer, glioblastoma, and lymphoma .

HY-168725

PROTAC KSP degrader 1	PROTACs Kinesin Apoptosis	Cancer
PROTAC KSP degrader 1 (Compound 21) is a PROTAC Degrader for **kinesin spindle protein (KSP), that degrades KSP in HCT-116 with DC₅₀** of 114.8 nM. PROTAC KSP degrader 1 inhibits the proliferation of HCT-116 with IC₅₀ of 10 nM, arrests the cell cycle of HCT-116 at G2/M phase, and induces apoptosis in HCT-116. PROTAC KSP degrader 1 exhibits antitumor efficacy in mouse model . (Blue: Ligand for E3 Ligase Cereblon (HY-103596); Blank: Linker (HY-168726); Pink: Target Protein Ligand (HY-168727))

HY-50759A

Ispinesib mesylate SB-715992 mesylate; CK-0238273 mesylate	Kinesin Apoptosis	Cancer
Ispinesib (SB-715992) mesylate is a specific inhibitor of kinesin spindle protein (KSP), with a K_{i app} of 1.7 nM.

HY-50759R

Ispinesib (Standard) SB-715992 (Standard); CK-0238273 (Standard)	Kinesin Apoptosis Reference Standards	Cancer
Ispinesib (Standard) is the analytical standard of Ispinesib. This product is intended for research and analytical applications. Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.

HY-50759S

Ispinesib-d5 SB-715992-d₅	Kinesin Apoptosis	Cancer
Ispinesib-d₅ (SB-715992-d₅) is a deuterium labeled Ispinesib (HY-50759). Ispinesib is a specific inhibitor of kinesin spindle protein (KSP) .

HY-15187B

Filanesib TFA ARRY-520 TFA	Kinesin	Cancer
Filanesib TFA (ARRY-520 TFA) is a selective kinesin spindle protein (KSP) inhibitor, with an IC₅₀ of 6 nM for human KSP. Filanesib TFA induces cell death by apoptosis in vitro. Filanesib TFA has potent anti-proliferative activity .

HY-117440

4'-Methoxy-S-trityl-L-cysteinol	Kinesin	Cancer
4'-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor of vertebrate Kinesin Spindle Protein (KSP). 4'-Methoxy-S-trityl-L-cysteinol significantly enhances its inhibitory activity against NCI60 tumor cells by modifying the trityl and cysteine groups. Its EC50 for bipolar spindle formation is 28 μM, showing stronger inhibitory potency than the parent molecule and monastrol.

HY-179355

KSP-IN-1	Kinesin	Cancer
KSP-IN-2 (compound 12) is a kinesin spindle protein (KSP) inhibitor with an IC₅₀ of 450 nM .

Ispinesib-d5
Ispinesib-d₅ (SB-715992-d₅) is a deuterium labeled Ispinesib (HY-50759). Ispinesib is a specific inhibitor of kinesin spindle protein (KSP) .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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