PROTAC KSP degrader 1
PROTAC KSP degrader 1 (Compound 21) is a PROTAC Degrader for kinesin spindle protein (KSP), that degrades KSP in HCT-116 with DC50 of 114.8 nM. PROTAC KSP degrader 1 inhibits the proliferation of HCT-116 with IC50 of 10 nM, arrests the cell cycle of HCT-116 at G2/M phase, and induces apoptosis in HCT-116. PROTAC KSP degrader 1 exhibits antitumor efficacy in mouse model.
(Pink: KSP ligand (HY-168727); Blue: Cereblon ligand (HY-103596); Black: linker (HY-168726)).
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 3099825-86-9
- Fòrmula: C48H51N5O8S
- Peso molecular:858.01
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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KSP 114.8 nM (DC50) |
Chemical Information
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No. CAS 3099825-86-9
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Peso molecular 858.01
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Fòrmula C48H51N5O8S
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SMILES
O=C(NCCCCCCCCNC(COC1=C2C(C(N(C3CCC(NC3=O)=O)C2=O)=O)=CC=C1)=O)[C@@H](N)CSC4(C5=CC=C(OC)C=C5)C6=CC=CC=C6C=CC7=C4C=CC=C7
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC KSP degrader 1 Related Classifications
HY-168725 Related Classifications
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