4'-Methoxy-S-trityl-L-cysteinol

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4'-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor of vertebrate Kinesin Spindle Protein (KSP). 4'-Methoxy-S-trityl-L-cysteinol significantly enhances its inhibitory activity against NCI60 tumor cells by modifying the trityl and cysteine groups. Its EC50 for bipolar spindle formation is 28 μM, showing stronger inhibitory potency than the parent molecule and monastrol.

For research use only. We do not sell to patients.

4'-Methoxy-S-trityl-L-cysteinol Chemical Structure

CAS No. : 1338701-15-7

Size	Stock	Quantity
1 mg	Get quote 2 - 3 weeks 4 - 5 weeks 5 - 6 weeks 1 - 2 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 2 - 3 weeks 4 - 5 weeks 5 - 6 weeks 1 - 2 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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•Related Screening Libraries:

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View All Isoforms

Kinesin-5/Eg5/KSP Kinesin-6 Kinesin-7/CENP-E Kinesin-12 Kinesin-14 Kinesin-13

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	0.44 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human 786-0 cells Growth inhibition of human 786-0 cells	[PMID: 21855351]
A549	GI₅₀	0.33 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human A549 cells Growth inhibition of human A549 cells	[PMID: 21855351]
ACHN	GI₅₀	0.49 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human ACHN cells Growth inhibition of human ACHN cells	[PMID: 21855351]
CAKI-1	GI₅₀	0.45 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human Caki1 cells Growth inhibition of human Caki1 cells	[PMID: 21855351]
CCRF-CEM	GI₅₀	0.1 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human CCRF-CEM cells Growth inhibition of human CCRF-CEM cells	[PMID: 21855351]
COLO 205	GI₅₀	0.08 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human COLO205 cells Growth inhibition of human COLO205 cells	[PMID: 21855351]
EKVX	GI₅₀	0.51 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human EKVX cells Growth inhibition of human EKVX cells	[PMID: 21855351]
HCC 2998	GI₅₀	0.05 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human HCC2998 cells Growth inhibition of human HCC2998 cells	[PMID: 21855351]
HCT-116	GI₅₀	0.03 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human HCT116 cells Growth inhibition of human HCT116 cells	[PMID: 21855351]
HCT-15	GI₅₀	0.21 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human HCT15 cells Growth inhibition of human HCT15 cells	[PMID: 21855351]
HL-60(TB)	GI₅₀	0.19 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human HL-60(TB) cells Growth inhibition of human HL-60(TB) cells	[PMID: 21855351]
HOP-62	GI₅₀	0.51 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human HOP62 cells Growth inhibition of human HOP62 cells	[PMID: 21855351]
HT-29	GI₅₀	0.34 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human HT-29 cells Growth inhibition of human HT-29 cells	[PMID: 21855351]
HeLa	EC₅₀	0.19 μM Compound: 5, MSTCO, NSC-747880	Inhibition of KSP in human HeLa cells assessed as bipolar spindle formation Inhibition of KSP in human HeLa cells assessed as bipolar spindle formation	[PMID: 21855351]
IGROV-1	GI₅₀	0.26 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human IGROV1 cells Growth inhibition of human IGROV1 cells	[PMID: 21855351]
K562	GI₅₀	0.06 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human K562 cells Growth inhibition of human K562 cells	[PMID: 21855351]
KM12	GI₅₀	0.22 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human KM12 cells Growth inhibition of human KM12 cells	[PMID: 21855351]
LOX IMVI	GI₅₀	0.49 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human LOXIMVI cells Growth inhibition of human LOXIMVI cells	[PMID: 21855351]
M14	GI₅₀	0.02 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human M14 cells Growth inhibition of human M14 cells	[PMID: 21855351]
MOLT-4	GI₅₀	0.28 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human MOLT4 cells Growth inhibition of human MOLT4 cells	[PMID: 21855351]
Malme-3M	GI₅₀	0.36 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human MALME-3M cells Growth inhibition of human MALME-3M cells	[PMID: 21855351]
NCI-H226	GI₅₀	2.75 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human NCI-H226 cells Growth inhibition of human NCI-H226 cells	[PMID: 21855351]
NCI-H23	GI₅₀	0.26 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human NCI-H23 cells Growth inhibition of human NCI-H23 cells	[PMID: 21855351]
NCI-H322M	GI₅₀	0.11 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human NCI-H322M cells Growth inhibition of human NCI-H322M cells	[PMID: 21855351]
NCI-H522	GI₅₀	0.22 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human NCI-H522 cells Growth inhibition of human NCI-H522 cells	[PMID: 21855351]
OVCAR-3	GI₅₀	0.2 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human OVCAR3 cells Growth inhibition of human OVCAR3 cells	[PMID: 21855351]
OVCAR-4	GI₅₀	1.62 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human OVCAR4 cells Growth inhibition of human OVCAR4 cells	[PMID: 21855351]
OVCAR-5	GI₅₀	0.39 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human OVCAR5 cells Growth inhibition of human OVCAR5 cells	[PMID: 21855351]
OVCAR-8	GI₅₀	0.42 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human OVCAR8 cells Growth inhibition of human OVCAR8 cells	[PMID: 21855351]
SF-268	GI₅₀	0.11 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SF268 cells Growth inhibition of human SF268 cells	[PMID: 21855351]
SF-295	GI₅₀	0.28 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SF295 cells Growth inhibition of human SF295 cells	[PMID: 21855351]
SF-539	GI₅₀	0.26 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SF539 cells Growth inhibition of human SF539 cells	[PMID: 21855351]
SK-MEL-2	GI₅₀	0.24 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SK-MEL-2 cells Growth inhibition of human SK-MEL-2 cells	[PMID: 21855351]
SK-MEL-28	GI₅₀	0.62 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SK-MEL-28 cells Growth inhibition of human SK-MEL-28 cells	[PMID: 21855351]
SK-MEL-5	GI₅₀	0.06 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SK-MEL-5 cells Growth inhibition of human SK-MEL-5 cells	[PMID: 21855351]
SK-OV-3	GI₅₀	0.08 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SKOV3 cells Growth inhibition of human SKOV3 cells	[PMID: 21855351]
SN12C	GI₅₀	0.32 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SN12C cells Growth inhibition of human SN12C cells	[PMID: 21855351]
SNB-19	GI₅₀	0.25 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SNB19 cells Growth inhibition of human SNB19 cells	[PMID: 21855351]
SNB-75	GI₅₀	0.26 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SNB75 cells Growth inhibition of human SNB75 cells	[PMID: 21855351]
SR	GI₅₀	0.01 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SR cells Growth inhibition of human SR cells	[PMID: 21855351]
SW-620	GI₅₀	0.07 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SW620 cells Growth inhibition of human SW620 cells	[PMID: 21855351]
TK-10	GI₅₀	0.46 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human TK10 cells Growth inhibition of human TK10 cells	[PMID: 21855351]
U-251	GI₅₀	0.19 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human U251 cells Growth inhibition of human U251 cells	[PMID: 21855351]
UACC-257	GI₅₀	0.54 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human UACC257 cells Growth inhibition of human UACC257 cells	[PMID: 21855351]
UACC-62	GI₅₀	0.25 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human UACC62 cells Growth inhibition of human UACC62 cells	[PMID: 21855351]
UO-31	GI₅₀	1.1 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human UO31 cells Growth inhibition of human UO31 cells	[PMID: 21855351]

Molecular Weight

379.52

Formula

C₂₃H₂₅NO₂S

CAS No.

1338701-15-7

SMILES

OC[C@@H](N)CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=C(C=C3)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity