1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Kinesin
  3. ARQ 621

ARQ 621 

Cat. No.: HY-16062
Handling Instructions

ARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity. ARQ 621 is a kinesin inhibitor.

For research use only. We do not sell to patients.

ARQ 621 Chemical Structure

ARQ 621 Chemical Structure

CAS No. : 1095253-39-6

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Description

ARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity[1]. ARQ 621 is a kinesin inhibitor[2].

IC50 & Target[1]

Eg5

 

In Vitro

Over-expression of Eg5 causes genomic instability and tumor formation in mice; therefore, Eg5 is a potential anti-cancer target[1].

Molecular Weight

552.43

Formula

C₂₈H₂₄Cl₂FN₅O₂

CAS No.

1095253-39-6

SMILES

O=C(N(CCCN)[[email protected]@H](C(N1NC2=CC=CC=C2)=NC3=C(C=CC(Cl)=C3)C1=O)CC#C)C4=CC=CC(Cl)=C4F

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ARQ 621ARQ621ARQ-621KinesinEg5microtubulemotorproteincelldivisionAnti-tumorkinesinInhibitorinhibitorinhibit

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