1338701-15-7
Chemical Structure
4'-Methoxy-S-trityl-L-cysteinol
- CAS No.: 1338701-15-7
- Formula:C23H25NO2S
- Molecular Weight:379.52
IUPAC Name: (R)-2-amino-3-(((4-methoxyphenyl)diphenylmethyl)thio)propan-1-ol
InChIKey: WKYHDWRETJHQFE-OAQYLSRUSA-N
SMILES: OC[C@@H](N)CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=C(C=C3)OC
Biological Activity: 4'-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor of vertebrate Kinesin Spindle Protein (KSP). 4'-Methoxy-S-trityl-L-cysteinol significantly enhances its inhibitory activity against NCI60 tumor cells by modifying the trityl and cysteine groups. Its EC50 for bipolar spindle formation is 28 μM, showing stronger inhibitory potency than the parent molecule and monastrol.
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4'-Methoxy-S-trityl-L-cysteinol | 4'-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor of vertebrate Kinesin Spindle Protein (KSP). 4'-Methoxy-S-trityl-L-cysteinol significantly enhances its inhibitory activity against NCI60 tumor cells by modifying the trityl and cysteine groups. Its EC50 for bipolar spindle formation is 28 μM, showing stronger inhibitory potency than the parent molecule and monastrol. | |||||||||||||||||||||
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Keywords
