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mitomycin

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By Targets:	Antibiotic (2) ATM/ATR (1) Bacterial (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (1) Drug Derivative (6) Drug Intermediate (3) Drug Metabolite (2) Isotope-Labeled Compounds (1) Macrophage migration inhibitory factor (MIF) (2) MDM-2/p53 (1) RAD51 (1) Reference Standards (1) Thrombin (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (1) Infection (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17378

Dabigatran ethyl ester 1 Publications Verification	Thrombin	Cardiovascular Disease
Dabigatran ethyl ester is an inhibitor of ribosyldihydronicotinamide dehydrogenase (NQO2) and thrombin. Dabigatran ethyl ester inhibits NADH-dependent metabolism of mitomycin C mediated by purified recombinant human NQO2 .

HY-130332

Mitomycin A	Macrophage migration inhibitory factor (MIF)	Cancer
Mitomycin A is an antitumor agent. Mitomycin A inhibits the spontaneous migration of mouse monocytes. Mitomycin A inhibits the production of MIF (Migration Inhibition Factor) by human lymphocytes. Mitomycin A can be used in the research of tumor diseases .

HY-W077634

3-Amino-5-hydroxybenzoic acid AHBA	Drug Intermediate	Infection
3-Amino-5-hydroxybenzoic acid is a biosynthetic precursor of the mC7N unit of ansamycin antibiotics, including ansatrienin A and geldanamycin, as well as the antitumor antibiotic mitomycin C. 3-Amino-5-hydroxybenzoic acid may be an early intermediate in the shikimic acid pathway from glucose .

HY-W338852

Gentisuric acid	Drug Metabolite	Cancer
Gentisuric acid, a metabolite of Aspirin (HY-14654), is a substrate of α-amidating monooxygenase (PAM). Gentisuric acid prevents DNA-damage by Mitomycin C (HY-13316) .

HY-167880

BMY-25551	Macrophage migration inhibitory factor (MIF)	Cancer
BMY-25551 is a Mitomycin A (HY-130332) analogue that is 8 to 20 times more potent than Mitomycin C (HY-13316) in cytotoxicity to murine and human tumor cell lines. BMY-25551 can be utilized in cancer and hematologic depression research .

HY-119044

KW-2149 KT-6149	Drug Derivative DNA Alkylator/Crosslinker	Cancer
KW-2149 (KT-6149) is a Mitomycin C (HY-13316) analogue activated by serum. KW-2149 can interact with DNA. KW-2149 exhibits antitumor activity. KW-2149 has pulmonary toxicity KW-2149 can be used for the research of cancer, such as leukemia .

HY-167635

Decarbamoylmitomycin C	MDM-2/p53 Drug Derivative ATM/ATR	Cancer
Decarbamoylmitomycin C, an analog of Mitomycin C (MC), is an DNA-alkylating agent. Decarbamoylmitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction .

HY-169500

Mitomycin Z 9a-O-Demethylmitomycin G	Drug Derivative	Cancer
Mitomycin Z (9a-O-Demethylmitomycin G) is a member of the mitomycin family with an antitumor activity .

HY-N14781

10-Decarbamoyloxy-9-dehydromitomycin B	Antibiotic Bacterial	Infection Cancer
10-Decarbamoyloxy-9-dehydromitomycin B is a mitomycin. 10-Decarbamoyloxy-9-dehydromitomycin B has antibacterial and antitumor activity .

HY-120436

RM 49	Drug Derivative	Cancer
RM 49 is the derivative of Mitomycin C (HY-13316). RM 49 exhibits cytotoxicity in SCLC and NSCLC lung cancer cells with IC₅₀ of 0.01-0.5 μg/mL. RM 49 exhibits high relative antitumor activity in compared with Mitomycin C, Cisplatin (HY-17394), Carboplatin (HY-17393) and Doxorubicin (HY-15142) .

HY-W338852R

Gentisuric acid (Standard)	Drug Metabolite Reference Standards	Cancer
Gentisuric acid (Standard) is the analytical standard of Gentisuric acid. This product is intended for research and analytical applications. Gentisuric acid, a metabolite of Aspirin (HY-14654), is a substrate of α-amidating monooxygenase (PAM). Gentisuric acid prevents DNA-damage by Mitomycin C (HY-13316)[1][2].

HY-169622

RAD51-IN-9	RAD51	Others
RAD51-IN-9 (Compound 3a) is a RAD51 inhibitor that can inhibit the binding of RAD51 to ssDNA with an IC₅₀ of 17.85 μM. RAD51-IN-9 has a LD₅₀ against HEK293 cells of 40.21 μM. RAD51-IN-9 can sensitize cells to Mitomycin C (HY-13316) .

HY-N14221

Eponemycin	Antibiotic DNA/RNA Synthesis	Infection Cancer
Eponemycin is an antibiotic that exhibits antitumor activity. Eponemycin exhibits cytotoxicity in cancer cells B16-F10, L1210, P388 and HCT-116 with IC₅₀ of 0.0017, 0.01, 0.031 and 0.0097 µg/mL, respectively. Eponemycin inhibits the DNA synthesis in B16-F10 and Mitomycin C with IC₅₀ of 0.1 µg/mL and 0.41 µg/mL .

HY-178299S

3-Amino-5-hydroxybenzoic acid-13C	Isotope-Labeled Compounds Drug Intermediate	Infection
3-Amino-5-hydroxybenzoic acid- ¹³C is the ¹³C-labeled 3-Amino-5-hydroxybenzoic acid (HY-W077634). 3-Amino-5-hydroxybenzoic acid is a biosynthetic precursor of the mC7N unit of ansamycin antibiotics, including ansatrienin A and geldanamycin, as well as the antitumor antibiotic mitomycin C. 3-Amino-5-hydroxybenzoic acid may be an early intermediate in the shikimic acid pathway from glucose .

HY-185585

JNJ-27548547	Drug Intermediate	Cancer
JNJ-27548547, Mitomycin C (HY-13316) prodrug, is a Mitomycin C and lipophilic group conjugate. JNJ-27548547 undergoes thiolytic cleavage of its dithiobenzyl linker in the presence of reducing agents to release active substance Mitomycin C. JNJ-27548547 is formulated into pegylated liposomes (PL-MLP) with high antitumor activity in mice models .

HY-131939

BMS 181174	Drug Derivative	Cancer
BMS 181174 is a Mitomycin C (HY-13316) analogue. BMS 181174 exhibits anticancer activity and can be used for the research of cancer, such as colorectal cancer .

HY-105361

BMY 25282 BL 6782	Drug Derivative	Cancer
BMY 25282 (BL 6782) is a mitomycin C (MMC) analog. BMY 25282 catalyzes oxygen activation in hepatocytes. BMY 25282 overcomes MMC tolerance in colon cancer cells and mouse models of colon cancer. BMY 25282 inhibits tumor growth in mouse models of leukemia and melanoma. BMY 25282 can be used in research on cancers such as leukemia, melanoma, and colon cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-130332

Mitomycin A	Quinones Structural Classification Classification of Application Fields Benzene Quinones Endogenous metabolite Disease Research Fields Source Classification Cancer	Macrophage migration inhibitory factor (MIF)
Mitomycin A is an antitumor agent. Mitomycin A inhibits the spontaneous migration of mouse monocytes. Mitomycin A inhibits the production of MIF (Migration Inhibition Factor) by human lymphocytes. Mitomycin A can be used in the research of tumor diseases .

HY-169500

Mitomycin Z 9a-O-Demethylmitomycin G	Quinones Structural Classification Microorganisms Benzene Quinones Source Classification	Drug Derivative
Mitomycin Z (9a-O-Demethylmitomycin G) is a member of the mitomycin family with an antitumor activity .

HY-N14781

10-Decarbamoyloxy-9-dehydromitomycin B	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
10-Decarbamoyloxy-9-dehydromitomycin B is a mitomycin. 10-Decarbamoyloxy-9-dehydromitomycin B has antibacterial and antitumor activity .

HY-N14221

Eponemycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic DNA/RNA Synthesis
Eponemycin is an antibiotic that exhibits antitumor activity. Eponemycin exhibits cytotoxicity in cancer cells B16-F10, L1210, P388 and HCT-116 with IC₅₀ of 0.0017, 0.01, 0.031 and 0.0097 µg/mL, respectively. Eponemycin inhibits the DNA synthesis in B16-F10 and Mitomycin C with IC₅₀ of 0.1 µg/mL and 0.41 µg/mL .

Cat. No.	Product Name	Chemical Structure

HY-178299S

3-Amino-5-hydroxybenzoic acid-13C
3-Amino-5-hydroxybenzoic acid- ¹³C is the ¹³C-labeled 3-Amino-5-hydroxybenzoic acid (HY-W077634). 3-Amino-5-hydroxybenzoic acid is a biosynthetic precursor of the mC7N unit of ansamycin antibiotics, including ansatrienin A and geldanamycin, as well as the antitumor antibiotic mitomycin C. 3-Amino-5-hydroxybenzoic acid may be an early intermediate in the shikimic acid pathway from glucose .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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mitomycin

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products