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oligonucleotide chain

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) DNA/RNA Synthesis (3) Isotope-Labeled Compounds (1) Nucleoside Antimetabolite/Analog (1) Phosphoramidites (3) SOD (3)
By Research Areas:	Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Adenine (1) Cytosine (1) Antisense Oligonucleotides (3) Other Phosphoramidite (1) Phosphoramidites (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Antibody-Oligonucleotide Conjugates (AOCs) Branched Chain Amino Acid Transaminase (BCAT) ELOVL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132580

Tofersen 2 Publications Verification BIIB067; ISIS-SOD1Rx; ISIS 333611	SOD	Neurological Disease
Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .

HY-158712

3'-ONH2-dATP sodium solution (100 mM)		Others
3'-ONH2-dATP (sodium) solution (100 mM) is a 3'-O-blocked reversible terminator deoxynucleotide triphosphate.3'-ONH2-dATP (sodium) solution (100 mM) stops DNA polymerization after single-nucleotide addition to an initiator strand, and its 3'-ONH2 blocking group can be removed to restore a free 3'-OH for subsequent extension.3'-ONH2-dATP (sodium) solution (100 mM) incorporates into an oligonucleotide chain by engineered terminal deoxynucleotidyl transferase from Zonotrichia albicollis to enable template-free, stepwise de novo enzymatic DNA synthesis .

HY-132580A

Tofersen sodium 2 Publications Verification BIIB067 sodium; ISIS-SOD1Rx sodium; ISIS 333611 sodium	SOD	Neurological Disease
Tofersen (BIIB067) sodium is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen sodium mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen sodium downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen sodium can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .

HY-46317

DMT-5Me-dC(Bz)-CE Phosphoramidite	Phosphoramidites DNA/RNA Synthesis	Metabolic Disease
DMT-5Me-dC(Bz)-CE Phosphoramidite is a chemical structural unit that can be used in solid-phase DNA synthesis. DMT-5Me-dC(Bz)-CE Phosphoramidite can introduce the 5-methylcytidine base into the DNA chain to enhance its stability and binding affinity. DMT-5Me-dC(Bz)-CE Phosphoramidite can be used to construct modified oligonucleotides, especially for constructing locked nucleic acids (LNA) .

HY-151651

Hexaethylene glycol phosphoramidite Spacer Phosphoramidite 18	Phosphoramidites	Others
Hexaethylene glycol phosphoramidite (Spacer Phosphoramidite 18) is an amidite reagent for oligonucleotide synthesis. Hexaethylene glycol phosphoramidite can be used as a linker in synthesis of nucleotide chain and qPCR probes .

HY-164583

DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite	Phosphoramidites DNA/RNA Synthesis	Others
DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite allows site-specific introduction of a 2'-O-C22 lipophilic modification at adenosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipophilicity and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules .

HY-W1119950

3'-NH-Tr-2',3'-DMF-ddA- 5'-CE-Phosphoramidite	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite is an adenine nucleotide monomer precursor used in solid-phase synthesis of oligonucleotides, particularly modified oligonucleotides, such as those with DNA chain end modifications. 3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite, with trityl (Tr), cyanoethyl (CE), and dimethylformamidine (DMF) protecting groups, is a ddNTP adenosine nucleoside useful in applications such as solid-phase oligonucleotide synthesis, probe design, and chain-termination sequencing .

HY-132580S

Tofersen-d27 BIIB067-d₂₇; ISIS-SOD1Rx-d₂₇; ISIS 333611-d₂₇	Isotope-Labeled Compounds SOD	Neurological Disease
Tofersen-d₂₇ (BIIB067-d₂₇) is the deuterium labeled Tofersen (HY-132580). Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis.

HY-W800819

Arachidic acid N-hydroxysuccinimide ester	Biochemical Assay Reagents	Others
Arachidic Acid N-Hydroxysuccinimide Ester is a lipid comprised of a saturated fatty acid with a 20-carbon chain with a terminal NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Cat. No.	Product Name	Type

HY-158712

3'-ONH2-dATP sodium solution (100 mM)	Biochemical Assay Reagents
3'-ONH2-dATP (sodium) solution (100 mM) is a 3'-O-blocked reversible terminator deoxynucleotide triphosphate.3'-ONH2-dATP (sodium) solution (100 mM) stops DNA polymerization after single-nucleotide addition to an initiator strand, and its 3'-ONH2 blocking group can be removed to restore a free 3'-OH for subsequent extension.3'-ONH2-dATP (sodium) solution (100 mM) incorporates into an oligonucleotide chain by engineered terminal deoxynucleotidyl transferase from Zonotrichia albicollis to enable template-free, stepwise de novo enzymatic DNA synthesis .

3'-ONH2-dATP sodium solution (100 mM)

Biochemical Assay Reagents

3'-ONH2-dATP (sodium) solution (100 mM) is a 3'-O-blocked reversible terminator deoxynucleotide triphosphate.3'-ONH2-dATP (sodium) solution (100 mM) stops DNA polymerization after single-nucleotide addition to an initiator strand, and its 3'-ONH2 blocking group can be removed to restore a free 3'-OH for subsequent extension.3'-ONH2-dATP (sodium) solution (100 mM) incorporates into an oligonucleotide chain by engineered terminal deoxynucleotidyl transferase from Zonotrichia albicollis to enable template-free, stepwise de novo enzymatic DNA synthesis .

Cat. No.	Product Name	Chemical Structure

HY-132580S

Tofersen-d27
Tofersen-d₂₇ (BIIB067-d₂₇) is the deuterium labeled Tofersen (HY-132580). Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis.

Tofersen-d27

Tofersen-d₂₇ (BIIB067-d₂₇) is the deuterium labeled Tofersen (HY-132580). Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis.

Cat. No.	Product Name		Classification

HY-132580

Tofersen 2 Publications Verification BIIB067; ISIS-SOD1Rx; ISIS 333611		Antisense Oligonucleotides
Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .

HY-132580A

Tofersen sodium 2 Publications Verification BIIB067 sodium; ISIS-SOD1Rx sodium; ISIS 333611 sodium		Antisense Oligonucleotides
Tofersen (BIIB067) sodium is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen sodium mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen sodium downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen sodium can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .

HY-46317

DMT-5Me-dC(Bz)-CE Phosphoramidite		Phosphoramidites Cytosine
DMT-5Me-dC(Bz)-CE Phosphoramidite is a chemical structural unit that can be used in solid-phase DNA synthesis. DMT-5Me-dC(Bz)-CE Phosphoramidite can introduce the 5-methylcytidine base into the DNA chain to enhance its stability and binding affinity. DMT-5Me-dC(Bz)-CE Phosphoramidite can be used to construct modified oligonucleotides, especially for constructing locked nucleic acids (LNA) .

HY-151651

Hexaethylene glycol phosphoramidite Spacer Phosphoramidite 18		Phosphoramidites Other Phosphoramidite
Hexaethylene glycol phosphoramidite (Spacer Phosphoramidite 18) is an amidite reagent for oligonucleotide synthesis. Hexaethylene glycol phosphoramidite can be used as a linker in synthesis of nucleotide chain and qPCR probes .

HY-164583

DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite		Phosphoramidites Adenine
DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite allows site-specific introduction of a 2'-O-C22 lipophilic modification at adenosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipophilicity and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules .

HY-132580S

Tofersen-d27 BIIB067-d₂₇; ISIS-SOD1Rx-d₂₇; ISIS 333611-d₂₇		Antisense Oligonucleotides
Tofersen-d₂₇ (BIIB067-d₂₇) is the deuterium labeled Tofersen (HY-132580). Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis.

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