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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
p70 S6 kinase
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "p70 S6 kinase" in MCE Product Catalog:
7
7 Publications Verification
CCT128930 is a ATP-competitive and selective inhibitor of AKT (IC50=6 nM for AKT2). CCT128930 has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). Antitumor activity.
7
7 Publications Verification
CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC50=6 nM). CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. Antitumor activity .
2
2 Cited Publications
Cat. No.: HY-16071
CAS No.: 1056901-62-2
Target:
Research Areas:
AT13148 is an orally active and ATP-competitive, multi-AGC kinase inhibitor with IC50s of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.
2
2 Cited Publications
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SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A dihydrochloride also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A dihydrochloride can be used for inflammation research .
Synonyms: DS11252927
Research Areas:
D927 (DS11252927) is an orally active glucose transporter type 4 (GLUT4) translocation activator with an EC50 of 0.14 μM. D927 enhances the binding affinity of PI3Kα catalytic subunit p110α to canonical RAS proteins (KRAS4A, KRAS4B) and RRAS, RRAS2, MRAS. D927 activates the PI3Kα-AKT pathway (increasing phosphorylation of AKT, p70S6 kinase) without affecting the RAF-ERK1/2 pathway. D927 improves hyperglycemia in type 1 and type 2 diabetes mice model. D927 can be used for the study of glucose homeostasis disorders and diabetes .
Cat. No.: HY-P5449
CAS No.: 171783-08-7
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Synonyms: BIM V
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Research Areas:
Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 µM . Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70 s6k/p85 s6k (S6K) in vivo with an IC50 of 8 µM .
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GSK-25 is a potent, selective and orally bioavailable ROCK1 inhibitor (IC50=7 nM). GSK-25 maintains good selectivity against a panel of 31 kinases (>100 fold), as well as RSK1 and p70S6K (RSK1: IC50=398 nM, p70S6K: IC50=1 μM). GSK-25 inhibits P450 profile (IC50s of 2.5, 5.2, 2.5 µM for CYP2C9, CYP2D6, CYP3A4, respectively) .
Cat. No.: HY-N5008
CAS No.: 146100-02-9
Cat. No.: HY-P10042
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Research Areas:
Cat. No.: HY-114038
CAS No.: 607372-46-3
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Research Areas:
SB-747651A is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A can be used for inflammation research .
Cat. No.: HY-12059B
CAS No.: 2624336-89-4
AT7867 hydrochloride is a potent and orally active inhibitor of AKT and p70 S6 kinase. AT7867 hydrochloride has anticancer effect .
AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells .
Cat. No.: HY-P810610
Synonyms: 70 kDa ribosomal protein S6 kinase 1;
KS6B1_HUMAN;
p70 alpha;
p70 beta 1
p70 ribosomal S6 kinase alpha;
p70 ribosomal S6 kinase beta 1;
p70 S6 kinase alpha;
p70 S6 kinase;
p70 S6 kinase, alpha 1;
p70 S6 kinase, alpha 2;
p70 S6K;
p70 S6K-alpha;
p70 S6KA;
p70(S6K) alpha;
p70(S6K)-alpha;
p70-alpha;
p70-S6K 1;
p70-S6K;
p70S6K;
p70S6K1;
p70S6Kb;
PS6K;
Ribosomal protein S6 kinase 70kDa polypeptide 1;
Ribosomal protein S6 kinase beta 1;
Ribosomal protein S6 kinase beta-1;
Ribosomal protein S6 kinase I;
RPS6KB1;
S6K;
S6K-beta-1;
S6K1;
Serine/threonine kinase 14 alpha;
Serine/threonine-protein kinase 14A;
STK14A
Cat. No.: HY-P811554
Synonyms: 70 kDa ribosomal protein S6 kinase 1;
KS6B1_HUMAN;
p70 alpha;
p70 beta 1
p70 ribosomal S6 kinase alpha;
p70 ribosomal S6 kinase beta 1;
p70 S6 kinase alpha;
p70 S6 kinase;
p70 S6 kinase, alpha 1;
p70 S6 kinase, alpha 2;
p70 S6K;
p70 S6K-alpha;
p70 S6KA;
p70(S6K) alpha;
p70(S6K)-alpha;
p70-alpha;
p70-S6K 1;
p70-S6K;
p70S6K;
p70S6K1;
p70S6Kb;
PS6K;
Ribosomal protein S6 kinase 70kDa polypeptide 1;
Ribosomal protein S6 kinase beta 1;
Ribosomal protein S6 kinase beta-1;
Ribosomal protein S6 kinase I;
RPS6KB1;
S6K;
S6K-beta-1;
S6K1;
Serine/threonine kinase 14 alpha;
Serine/threonine-protein kinase 14A;
STK14A
Cat. No.: HY-P87710
Synonyms: STK14A, Ribosomal protein S6 kinase beta-1, S6K-beta-1, S6K1, 70 kDa ribosomal protein S6 kinase 1, Ribosomal protein S6 kinase I, Serine/threonine-protein kinase 14A, p70 ribosomal S6 kinase alpha, p70S6K1, p70-S6K 1, p70 S6 kinase alpha, p70 S6K-alpha, p70 S6KA
Cat. No.: HY-P81209
Synonyms: 70 kDa ribosomal protein S6 kinase 1 antibody;
KS6B1_HUMAN antibody;
p70 alpha antibody;
p70 beta 1 antibody
p70 ribosomal S6 kinase alpha antibody;
p70 ribosomal S6 kinase beta 1 antibody;
p70 S6 kinase alpha antibody;
p70 S6 kinase antibody;
p70 S6 kinase, alpha 1 antibody;
p70 S6 kinase, alpha 2 antibody;
p70 S6K antibody;
p70 S6K-alpha antibody;
p70 S6KA antibody;
p70(S6K) alpha antibody;
p70(S6K)-alpha antibody;
p70-alpha antibody;
p70-S6K 1 antibody;
p70-S6K antibody;
p70S6K antibody;
p70S6K1 antibody;
p70S6Kb antibody;
PS6K antibody;
Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody;
Ribosomal protein S6 kinase beta 1 antibody;
Ribosomal protein S6 kinase beta-1 antibody;
Ribosomal protein S6 kinase I antibody;
RPS6KB1 antibody;
S6K antibody;
S6K-beta-1 antibody;
S6K1 antibody;
Serine/threonine kinase 14 alpha antibody;
Serine/threonine-protein kinase 14A antibody;
STK14A antibody;
Cat. No.: HY-P81209A
Synonyms: 70 kDa ribosomal protein S6 kinase 1 antibody;
KS6B1_HUMAN antibody;
p70 alpha antibody;
p70 beta 1 antibody
p70 ribosomal S6 kinase alpha antibody;
p70 ribosomal S6 kinase beta 1 antibody;
p70 S6 kinase alpha antibody;
p70 S6 kinase antibody;
p70 S6 kinase, alpha 1 antibody;
p70 S6 kinase, alpha 2 antibody;
p70 S6K antibody;
p70 S6K-alpha antibody;
p70 S6KA antibody;
p70(S6K) alpha antibody;
p70(S6K)-alpha antibody;
p70-alpha antibody;
p70-S6K 1 antibody;
p70-S6K antibody;
p70S6K antibody;
p70S6K1 antibody;
p70S6Kb antibody;
PS6K antibody;
Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody;
Ribosomal protein S6 kinase beta 1 antibody;
Ribosomal protein S6 kinase beta-1 antibody;
Ribosomal protein S6 kinase I antibody;
RPS6KB1 antibody;
S6K antibody;
S6K-beta-1 antibody;
S6K1 antibody;
Serine/threonine kinase 14 alpha antibody;
Serine/threonine-protein kinase 14A antibody;
STK14A antibody;
Cat. No.: HY-P87835
Synonyms: STK14B, RPS6KB2, Ribosomal protein S6 kinase beta-2, S6K-beta-2, S6K2, 70 kDa ribosomal protein S6 kinase 2, S6 kinase-related kinase, Serine/threonine-protein kinase 14B, p70 ribosomal S6 kinase beta, p70S6K2, p70-S6K 2, SRK, S6K-beta, p70 S6 kinase beta, p70 S6K-beta, p70 S6KB, p70-beta
Cat. No.: HY-P81769
Synonyms: RPS6KB2; STK14B; Ribosomal protein S6 kinase beta-2; S6K-beta-2; S6K2; 70 kDa ribosomal protein S6 kinase 2; p70S6K2; p70-S6K 2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; p70
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
