Cat. No.: HY-110313

SB-747651A dihydrochloride

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC₅₀ of 11 nM. SB-747651A dihydrochloride also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A dihydrochloride can be used for inflammation research.

For research use only. We do not sell to patients.

Purity: 99.14%
CAS No.: 1781882-72-1
Formula: C₁₆H₂₄Cl₂N₈O
Molecular Weight:415.32

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

SB-747651A dihydrochloride Chemical Structure

CAS No.: 1781882-72-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 11 nM (MSK1)^[1]

All p38 MAPK Isoforms :

In Vitro

SB-747651A dihydrochloride (5 μM; neutrophils) affects CXCL2-induced intraluminal crawling of neutrophils in a Mac-1-dependent manner. SB-747651A dihydrochloride thwarts the intraluminal crawling of adherent neutrophils to optimal sites of emigration. SB-747651A dihydrochloride (5 μM; neutrophils) significantly increases transmigration time and detachment time. SB-747651A dihydrochloride affects mechanisms that regulate transendothelial migration of neutrophils in response to CXCL2 chemotactic gradient. SB-747651A dihydrochloride inhibits the migration speed of extravascular chemotaxing neutrophils but does not affect their directionality in response to CXCL2 chemotactic gradient^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SB747651A (3 mg/kg; intrascrotal injection) dihydrochloride results in increased neutrophil adhesion 3.5~4.5 hours following stimulation with CXCL2 as compared to the effect of CXCL2^[3].
SB-747651A (3 mg/kg; i.p.) dihydrochloride affects neutrophil extravasation by increasing neutrophil emigration only at 3 and 4 hours in mouse peritonitis model of acute inflammation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57BL/6N mice (8~16 weeks)^[3]
Dosage:

3 mg/kg
Administration:

Intrascrotal injection
Result:

Resulted in increased neutrophil adhesion 3.5~4.5 hours following stimulation with CXCL2 as compared to the effect of CXCL2.

Chemical Information

CAS No. 1781882-72-1
Appearance Solid
Molecular Weight 415.32
Formula C₁₆H₂₄Cl₂N₈O
Color White to off-white
SMILES

NC1=NON=C1C(N2CC)=NC3=C2C(CNC4CCNCC4)=CN=C3.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (2)

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Journal Impact Factor

J Cell Sci

Prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2. [Abstract]

2025 Sep 16:jcs.264193. PMID: 40955174
Harvard University

2026.

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (120.39 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4078 mL

12.0389 mL

24.0778 mL

5 mM

0.4816 mL

2.4078 mL

4.8156 mL

10 mM

0.2408 mL

1.2039 mL

2.4078 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shaista Naqvi, et al. Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem J. 2012 Jan 1;441(1):347-57. [Content Brief]

[2]. Feiner B, et al. Risperidone effects on heterochromatin: the role of kinase signaling. Clin Exp Immunol. 2019;196(1):67-75. [Content Brief]

[3]. Hossain M, et al. The Specific Mitogen- and Stress-Activated Protein Kinase MSK1 Inhibitor SB-747651A Modulates Chemokine-Induced Neutrophil Recruitment. Int J Mol Sci. 2017;18(10):2163. Published 2017 Oct 17. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	2.4078 mL	12.0389 mL	24.0778 mL	60.1945 mL
	5 mM	0.4816 mL	2.4078 mL	4.8156 mL	12.0389 mL
	10 mM	0.2408 mL	1.2039 mL	2.4078 mL	6.0195 mL
	15 mM	0.1605 mL	0.8026 mL	1.6052 mL	4.0130 mL
	20 mM	0.1204 mL	0.6019 mL	1.2039 mL	3.0097 mL
	25 mM	0.0963 mL	0.4816 mL	0.9631 mL	2.4078 mL
	30 mM	0.0803 mL	0.4013 mL	0.8026 mL	2.0065 mL
	40 mM	0.0602 mL	0.3010 mL	0.6019 mL	1.5049 mL
	50 mM	0.0482 mL	0.2408 mL	0.4816 mL	1.2039 mL
	60 mM	0.0401 mL	0.2006 mL	0.4013 mL	1.0032 mL
	80 mM	0.0301 mL	0.1505 mL	0.3010 mL	0.7524 mL
	100 mM	0.0241 mL	0.1204 mL	0.2408 mL	0.6019 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

SB-747651A dihydrochloride

2 Cited Publications

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SB-747651A dihydrochloride

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Publications Citing Use of MedChemExpress (MCE) SB-747651A dihydrochloride

All p38 MAPK Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

SB-747651A dihydrochloride Related Classifications

HY-110313 Related Classifications