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Cat. No.: HY-110313R

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SB-747651A dihydrochloride (Standard)

Name: SB-747651A dihydrochloride (Standard)
Brand: MedChemExpress
SKU: HY-110313R
Price: 220.00 USD
Availability: InStock
Rating: 5 (1 reviews)

SB-747651A (dihydrochloride) (Standard) is the analytical standard of SB-747651A (dihydrochloride). This product is intended for research and analytical applications. SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A dihydrochloride also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A dihydrochloride can be used for inflammation research.

For research use only. We do not sell to patients.

Purity: 95%
CAS No.: 1781882-72-1
Formula: C₁₆H₂₄Cl₂N₈O
Molecular Weight:415.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SB-747651A dihydrochloride (Standard) Chemical Structure

CAS No.: 1781882-72-1

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1781882-72-1
Molecular Weight 415.32
Formula C₁₆H₂₄Cl₂N₈O
SMILES

NC1=NON=C1C(N2CC)=NC3=C2C(CNC4CCNCC4)=CN=C3.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Shaista Naqvi, et al. Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem J. 2012 Jan 1;441(1):347-57. [Content Brief]

[2]. Feiner B, et al. Risperidone effects on heterochromatin: the role of kinase signaling. Clin Exp Immunol. 2019;196(1):67-75. [Content Brief]

[3]. Hossain M, et al. The Specific Mitogen- and Stress-Activated Protein Kinase MSK1 Inhibitor SB-747651A Modulates Chemokine-Induced Neutrophil Recruitment. Int J Mol Sci. 2017;18(10):2163. Published 2017 Oct 17. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SB-747651A dihydrochloride (Standard)

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SB-747651A dihydrochloride (Standard)