2. PI3K/Akt/mTOR
    Apoptosis
  3. Akt
    Apoptosis
  4. AKT-IN-3

AKT-IN-3 

Cat. No.: HY-126257 Purity: 99.29%
COA Handling Instructions

AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells.

For research use only. We do not sell to patients.

AKT-IN-3 Chemical Structure

AKT-IN-3 Chemical Structure

CAS No. : 2374740-21-1

Size Price Stock Quantity
5 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 4280 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Akt Akt1 Akt2 Akt3

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Description

AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells[1].

IC50 & Target[1]

Akt1

1.4 nM (IC50)

Akt2

1.2 nM (IC50)

Akt3

1.7 nM (IC50)

PKA

0.3 nM (IC50)

P70S6K

8.9 (IC50)

Molecular Weight

526.36

Appearance

Solid

Formula

C23H23Cl2F2N5O3
CAS No.
SMILES

CNC(C[[email protected]]1NC[[email protected]@H](NC(C2=CC(C3=C(Cl)C=NN3C)=C(Cl)O2)=O)[[email protected]](C4=CC(F)=C(F)C=C4)C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (189.98 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8998 mL 9.4992 mL 18.9984 mL
5 mM 0.3800 mL 1.8998 mL 3.7997 mL
10 mM 0.1900 mL 0.9499 mL 1.8998 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

Keywords:

AKT-IN-32374740-21-1AktApoptosisPKBProtein kinase BInhibitorinhibitorinhibit

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