1. PI3K/Akt/mTOR
    Apoptosis
  2. Akt
    Apoptosis
  3. AKT-IN-3

AKT-IN-3 

Cat. No.: HY-126257
Handling Instructions

AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells.

For research use only. We do not sell to patients.

AKT-IN-3 Chemical Structure

AKT-IN-3 Chemical Structure

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Description

AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells[1].

IC50 & Target

Akt1

1.4 nM (IC50)

Akt2

1.2 nM (IC50)

Akt3

1.7 nM (IC50)

PKA

0.3 nM (IC50)

P70S6K

8.9 (IC50)

Molecular Weight

526.36

Formula

C₂₃H₂₃Cl₂F₂N₅O₃

SMILES

CNC(C[[email protected]]1NC[[email protected]@H](NC(C2=CC(C3=C(Cl)C=NN3C)=C(Cl)O2)=O)[[email protected]](C4=CC(F)=C(F)C=C4)C1)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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AKT-IN-3
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HY-126257
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