P70 S6 Kinase beta/SRK (phospho S371) Antibody (YA1890)

Cat. No.: HY-P82145: Data Sheet COA
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User Guide for Antibodies
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P70 S6 Kinase beta/SRK (phospho S371) Antibody (YA1890) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to P70 S6 Kinase beta/SRK (phospho S371).

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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P70 S6 Kinase beta/SRK (phospho S371) Antibody (YA1890) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

P70 S6 Kinase beta/SRK (phospho S371) Antibody (YA1890) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to P70 S6 Kinase beta/SRK (phospho S371).

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 53 kDa;

Observed band size: 60 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9UBS0

Gene ID

6199 [NCBI]

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser371 of human P70 S6 Kinase beta

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Sensitivity	Endogenous	Purity	Affinity Purified
Conjugation	Non-conjugated	Modification	Phosphorylated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193)

Subcellular Localization：Cytoplasm; Nucleus

Isoforms & Post-Translational Modification：Q9UBS0 has 2 isomers: Q9UBS0-1: 53455 Da (predicted); Q9UBS0-2: 16868 Da (predicted).
Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention

RRID

AB_3104028

Database

Entrez Gene: 6199 Human ; 58988 Mouse ; 361696 Rat

SwissProt: Q9UBS0 Human ; Q9Z1M4 Mouse ;

OMIM: 608939 Human

Research Field

Signal Transduction

Synonyms

RPS6KB2; STK14B; Ribosomal protein S6 kinase beta-2; S6K-beta-2; S6K2; 70 kDa ribosomal protein S6 kinase 2; P70S6K2; p70-S6K 2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; p70

Documentation

Select Batch:

Data Sheet (232 KB) SDS (252 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

P70 S6 Kinase beta/SRK (phospho S371) Antibody (YA1890) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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P70 S6 Kinase beta/SRK (phospho S371) Antibody (YA1890)

P70 S6 Kinase beta/SRK (phospho S371) Antibody (YA1890) Featured Recommendations:

Product Detail

Background

Documentation

P70 S6 Kinase beta/SRK (phospho S371) Antibody (YA1890) Related Classifications

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