RPS6KB2 - ribosomal protein S6 kinase B2 Gene

Also Known as KLS; SRK; S6K2; S6KB; STK14B; S6KI(2); S6Kbeta; p70S6Kb; P70-beta; S6K-beta2; P70-beta-1; P70-beta-2; p70(S6K)-beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6199

About RPS6KB2

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,428,494-67,435,401 (from NCBI)

This gene has 12 transcripts (splice variants), 199 orthologues and 7 paralogues. Ubiquitous expression in skin (RPKM 31.3), esophagus (RPKM 20.5) and 25 other tissues.

Summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]

RPS6KB2 Products (5)

mRNA Protein Name
XM_006718656.4 XP_006718719.1 ribosomal protein S6 kinase beta-2 isoform X2
XM_047427395.1 XP_047283351.1 ribosomal protein S6 kinase beta-2 isoform X1
NM_003952.3 NP_003943.2 ribosomal protein S6 kinase beta-2
XM_047427396.1 XP_047283352.1 ribosomal protein S6 kinase beta-2 isoform X3
NM_001007071.1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
29750193 GOA
Biological Process GO Annotation Evidence References Source
involved in TOR signaling IMP
IMP: Inferred from mutant phenotype
29750193 GOA
involved in positive regulation of translational initiation IDA
IDA: Inferred from direct assay
29750193 GOA
involved in positive regulation of translational initiation IMP
IMP: Inferred from mutant phenotype
16763566 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS6KB2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (67 - 328)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (349 - 393)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 482 a.a.
Protein Preferred Names Protein Names

ribosomal protein S6 kinase beta-2

  • 70 kDa ribosomal protein S6 kinase 2

  • P70S6K2

  • S6 kinase-related kinase

  • S6K-beta

  • S6K-beta-2

  • p70 S6 kinase beta

  • p70 S6K-beta

  • p70 S6KB

  • p70 ribosomal S6 kinase beta

  • p70-S6K 2

  • ribosomal protein S6 kinase, 70kDa, polypeptide 2

  • serine/threonine-protein kinase 14 beta

  • serine/threonine-protein kinase 14B

RPS6KB2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81769 P70 S6 Kinase beta Antibody (YA1514) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P81769A P70 S6 Kinase beta Antibody (YA1514)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P82145 P70 S6 Kinase beta/SRK (phospho S371) Antibody (YA1890) WB Human, Mouse, Rat
HY-P82145A P70 S6 Kinase beta/SRK (phospho S371) Antibody (YA1890)(PBS only) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Coffin-Lowry Syndrome

  • CLS

  • Mental Retardation With Osteocartilaginous Abnormalities

  • Coffin Syndrome 1

  • Coffin Syndrome

  • Dwarfism, Lean Spastic Type

  • Lean Spastic Dwarfism

  • Coffin Lowry Syndrome
Spotted Fever

  • Spotted Fevers

  • Spotted Fever Group Rickettsial Disease

  • Tick-Borne Rickettsioses

  • Tick-Borne Typhus Nos

  • Rocky Mountain Spotted Fever

  • Sao Paulo Fever

  • Sao Paulo Typhus

  • Lone Star Spotted Fever

  • Colombian Spotted Fever

  • American Spotted Fever

  • Tick Typhus Due To Rickettsia Rickettsii

  • Rocky Mountain Tick Fever

  • Boutonneuse Fever

  • Mediterranean Tick Fever

  • Fièvre Boutonneuse

  • Mediterranean Spotted Fever

  • Tick Typhus Due To Rickettsia Conorii

  • African Tick Typhus

  • Indian Tick Typhus

  • Kenya Tick Typhus

  • North Asian Tick Fever

  • Siberian Tick Typhus

  • Tick Typhus Due To Rickettsia Siberica

  • North Asian Spotted Fever

  • Queensland Tick Typhus

  • Queensland Fever
Breast Cancer

  • Breast Carcinoma

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Male Breast Cancer

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12265 RPS6KB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12266 Rps6kb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12267 Rps6kb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RPS6KB2 VGNC VGNC:76934
Canis familiaris RPS6KB2 VGNC VGNC:45745
Bos taurus RPS6KB2 VGNC VGNC:34147
Mus musculus RPS6KB2 MGD MGI:1927343
Rattus norvegicus RPS6KB2 RGD RGD:1305144
Felis catus RPS6KB2 VGNC VGNC:64760
Others RPS6KB2 NCBI