Selepressin (Synonyms: FE 202158)

Name: Selepressin
Brand: MedChemExpress
SKU: HY-105239
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製品番号: HY-105239 純度: 98.17%: Data Sheet SDS COA 取扱説明書
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Selepressin (FE 202158) is a selective vasopressin V_1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock.

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Selepressin 構造式

CAS 番号 : 876296-47-8

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 1383	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 1383	在庫あり	Estimated Time of Arrival: December 31
Solid
1 mg	$320	在庫あり	Estimated Time of Arrival: December 31
5 mg	$750	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1200	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 0 publication(s) in Google Scholar

Other Forms of Selepressin:

Selepressin acetate 在庫あり
Selepressin (Standard) お問い合わせ

Vasopressin Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

V1a Receptor V1b Receptor V2 Receptor

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Selepressin (FE 202158) is a selective vasopressin V_1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock^[1]^[2]^[4].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	1100 nM Compound: 45, FE 202158	Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay	[PMID: 21688787]
Flp-In-293	EC₅₀	340 nM Compound: 45, FE 202158	Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay	[PMID: 21688787]
HEK293	EC₅₀	0.55 nM Compound: 45, FE 202158	Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 21688787]
HEK293	EC₅₀	2.4 nM Compound: 45, FE 202158	Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 21688787]
HEK293	EC₅₀	2700 nM Compound: 45, FE 202158	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 21688787]

体外実験

Selepressin (100 nM, 48 or 72 h) ameliorates thrombin or VEGF-induced HLMVECs barrier dysfunction^[4].
Selepressin (1-1000 nM, 72 h) prevents the LPS-Induced loss of VE-cadherin and cortical actin in HLMVECs^[4].
Selepressin (100 nM, 48 h) induces the expression of the barrier-protective p53 in HLMVECs^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	HLMVECs
Concentration:	1, 10, 100, 1000 nM
Incubation Time:	24 h, 48 h
Result:	Induced p53 expression levels, but only after treatment of 48 hours at 100 nM.

体内実験

Selepressin (1 μg/kg/min, left jugular vein infusion for 12 min) increases 38.5% of the mean arterial pressure (MAP) in LPS-induced, fluid-resuscitated rabbit endotoxemia model^[2].
Selepressin (7 pmol/kg/min, 10 μL/min, i.v. infusion) blocks vascular leak in ovine severe sepsis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	LPS-induced, fluid-resuscitated rabbit endotoxemia model^[2].
Dosage:	1 μg/kg/min
Administration:	Left jugular vein infusion for 12 min
Result:	Decreased mesenteric blood flow (MBF) and increased mesenteric vascular resistance in non-endotoxemic and endotoxemic rabbits.

分子量

1048.28

分子式

C₄₆H₇₃N₁₃O₁₁S₂

CAS 番号

876296-47-8

Appearance

Solid

Color

White to off-white

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Sealed storage, away from moisture
Powder	-80°C	2 years
	-20°C	1 year
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (95.39 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9539 mL	4.7697 mL	9.5394 mL
5 mM	0.1908 mL	0.9539 mL	1.9079 mL
10 mM	0.0954 mL	0.4770 mL	0.9539 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.17%

Select Batch:

データシート (280 KB) SDS (252 KB)

COA (258 KB) LCMS (88 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Russell JA, et al. Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients. Crit Care. 2017 Aug 15;21(1):213. [Content Brief]

[2]. Milano SP, et al. Selepressin, a novel selective V1A receptor agonist: Effect on mesenteric flow and gastric mucosa perfusion in the endotoxemic rabbit. Peptides. 2020 Jul;129:170318. [Content Brief]

[3]. Barabutis N, et al. Protective Mechanism of the Selective Vasopressin V1A Receptor Agonist Selepressin against Endothelial Barrier Dysfunction. J Pharmacol Exp Ther. 2020 Nov;375(2):286-295. [Content Brief]

[4]. Maybauer MO, et al. The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*. Crit Care Med. 2014 Jul;42(7):e525-e533. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9539 mL	4.7697 mL	9.5394 mL	23.8486 mL
	5 mM	0.1908 mL	0.9539 mL	1.9079 mL	4.7697 mL
	10 mM	0.0954 mL	0.4770 mL	0.9539 mL	2.3849 mL
	15 mM	0.0636 mL	0.3180 mL	0.6360 mL	1.5899 mL
	20 mM	0.0477 mL	0.2385 mL	0.4770 mL	1.1924 mL
	25 mM	0.0382 mL	0.1908 mL	0.3816 mL	0.9539 mL
	30 mM	0.0318 mL	0.1590 mL	0.3180 mL	0.7950 mL
	40 mM	0.0238 mL	0.1192 mL	0.2385 mL	0.5962 mL
	50 mM	0.0191 mL	0.0954 mL	0.1908 mL	0.4770 mL
	60 mM	0.0159 mL	0.0795 mL	0.1590 mL	0.3975 mL
	80 mM	0.0119 mL	0.0596 mL	0.1192 mL	0.2981 mL

Selepressin Related Classifications

Cardiovascular Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Selepressin876296-47-8FE 202158FE202158FE-202158Vasopressin ReceptorEndotoxemiathrombinvasopressorsepsisInhibitorinhibitorinhibit

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Selepressin (Synonyms: FE 202158)

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Molarity Calculator

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Complete Stock Solution Preparation Table

Selepressin Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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•関連スクリーニングライブラリ:

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Vasopressin Receptor アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Selepressin 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Selepressin Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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