876296-47-8
Chemical Structure
Selepressin
Synonym(s): FE 202158
- CAS No.: 876296-47-8
- Formula:C46H73N13O11S2
- Molecular Weight:1048.28
IUPAC Name: (S)-N-((S)-1-((2-amino-2-oxoethyl)amino)-5-(isopropylamino)-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(4-amino-4-oxobutyl)-16-benzyl-13-((S)-sec-butyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan
InChIKey: JCVQBJTWWDYUFQ-MRUTUVJXSA-N
SMILES: O=C([C@H]1NC([C@@H](NC([C@@H](NC([C@](NC([C@@H](NC([C@H](CSSC1)N)=O)CC2=CC=CC=C2)=O)([H])[C@@H](C)CC)=O)CCCC(N)=O)=O)CC(N)=O)=O)N3[C@@H](CCC3)C(N[C@@H](CCCNC(C)C)C(NCC(N)=O)=O)=O
Biological Activity: Selepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock[1][2][4].
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Selepressin | 98.17% | Selepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock. | ||||||||||||||||||||
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Selepressin (Standard) | ≥98% | Selepressin (Standard) is the analytical standard of Selepressin (HY-105239). This product is intended for research and analytical applications. Selepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock. | ||||||||||||||||||||
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References
- [1]. Russell JA, et al. Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients. Crit Care. 2017 Aug 15;21(1):213. [Content Brief]
- [2]. Milano SP, et al. Selepressin, a novel selective V1A receptor agonist: Effect on mesenteric flow and gastric mucosa perfusion in the endotoxemic rabbit. Peptides. 2020 Jul;129:170318. [Content Brief]
- [4]. Maybauer MO, et al. The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*. Crit Care Med. 2014 Jul;42(7):e525-e533. [Content Brief]
