2. Others Cytoskeleton Membrane Transporter/Ion Channel Metabolic Enzyme/Protease NF-κB Apoptosis Anti-infection Immunology/Inflammation
  3. Reference Standards Exosomes Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2
  4. Shikonin (Standard)

Shikonin (Standard)  (Synonyms: C.I. 75535 (Standard); Isoarnebin 4 (Standard))

Cat. No.: HY-N0822R Pureza: 98.54%
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Shikonin (Standard) is the analytical standard of Shikonin. This product is intended for research and analytical applications. Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.

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Shikonin (Standard)

Shikonin (Standard) Estructura química

No. CAS : 517-89-5

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Information
Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Peso molecular

288.30

Fòrmula

C16H16O5
No. CAS
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C1C([C@H](O)C/C=C(C)/C)=CC(C2=C1C(O)=CC=C2O)=O
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Shikonin (Standard) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Shikonin (Standard)517-89-5C.I. 75535 (Standard) Isoarnebin 4 (Standard)Reference StandardsExosomesChloride ChannelPyruvate KinaseNF-κBTNF ReceptorHIVAIM2Cl− Channels Nuclear factor-κBNuclear factor-kappaBTumor Necrosis Factor ReceptorTNFRHuman immunodeficiency virusAbsent in melanoma 2Interferon-inducible protein AIM2PYHINInhibitorinhibitorinhibit

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Nombre del producto:
Shikonin (Standard)
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HY-N0822R
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