2. Immunology/Inflammation TGF-beta/Smad
  3. PD-1/PD-L1 TGF-β Receptor
  4. SHR-1701

SHR-1701  (Synonyms: Retlirafusp alfa)

Cat. No.: HY-P99944 Pureza: 99.77%
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SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and TGF-β for cancer research.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS : 2891860-17-4

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Based on 1 Customer Validation

SHR-1701 Recomendaciones destacadas:

SHR-1701 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas TGF-β Receptor:

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ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B BMP

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Descripciòn

SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and TGF-β for cancer research[1].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity

Human
In Vitro

SHR-1701 (10 μg/mL) can inhibit TGF-β signaling pathway, activate PI3K/Akt/Erk signaling pathway, rescue lymphocytes and restore the anti-tumor function of peripheral blood CD8+ T cells in patients with lung cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SHR-1701 Related Antibodies
Ensayo clínico
Gene ID

29126  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

174.61 kDa

Fòrmula

HS
No. CAS
Appearance

Liquid

Color

Colorless to light yellow

SMILES

S[R1701]
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized Human PD-L1/B7-H1 Protein (ECD, His Tag) can bind SHR-1701. The EC50 for this effect is 0.42 ng/mL.
Pureza y Documentación
Referencias
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SHR-1701 Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHR-17012891860-17-4Retlirafusp alfaSHR1701SHR 1701PD-1/PD-L1TGF-β ReceptorPD-1/Programmed death-ligand 1Transforming growth factor beta receptorsPD-L1TGF-βcancerInhibitorinhibitorinhibit

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Inquiry Information

Nombre del producto:
SHR-1701
Cat. No.:
HY-P99944
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MCE Japan Authorized Agent:

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