Spinosyn A

製品番号: HY-B0767 純度: 99.93%: Data Sheet SDS COA 取扱説明書
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Spinosyn A, a polyketide-derived macrolide produced by Saccharopolyspora spinosa, is a potent insecticide.

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Spinosyn A 構造式

CAS 番号 : 131929-60-7

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 862	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 862	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$535	在庫あり	Estimated Time of Arrival: December 31
10 mg	$735	在庫あり	Estimated Time of Arrival: December 31
25 mg	$1110	在庫あり	Estimated Time of Arrival: December 31
50 mg	$1470	在庫あり	Estimated Time of Arrival: December 31
100 mg	$2025	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other Forms of Spinosyn A:

Spinosyn D 在庫あり
Spinosad 在庫あり

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Spinosyn A, a polyketide-derived macrolide produced by Saccharopolyspora spinosa, is a potent insecticide^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	10.7 3 Compound: 1	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 30201293]
HCT-116	IC₅₀	10.7 3 Compound: 1	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 30201293]
HCT-116	IC₅₀	10.7 3 Compound: 1	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 30201293]
HCT-116	IC₅₀	11.1 3 Compound: 1	Antiproliferative activity against human HCT116 cells incubated for 48 hrs Antiproliferative activity against human HCT116 cells incubated for 48 hrs	[PMID: 32139325]
HCT-116	IC₅₀	11.1 3 Compound: 1	Antiproliferative activity against human HCT116 cells incubated for 48 hrs Antiproliferative activity against human HCT116 cells incubated for 48 hrs	[PMID: 32139325]
HCT-116	IC₅₀	11.1 3 Compound: 1	Antiproliferative activity against human HCT116 cells incubated for 48 hrs Antiproliferative activity against human HCT116 cells incubated for 48 hrs	[PMID: 32139325]
MCF7	IC₅₀	16.7 3 Compound: 1	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30201293]
HT-29	IC₅₀	7.3 3 Compound: SPA	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37682035]
HT-29	IC₅₀	7.3 3 Compound: SPA	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37682035]
MCF7	IC₅₀	17.9 3 Compound: 1	Antiproliferative activity against human MCF7 cells incubated for 48 hrs Antiproliferative activity against human MCF7 cells incubated for 48 hrs	[PMID: 32139325]
MCF7	IC₅₀	16.7 3 Compound: 1	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30201293]
NCI-H460	IC₅₀	66 3 Compound: 1	Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 30201293]
MCF7	IC₅₀	17.9 3 Compound: 1	Antiproliferative activity against human MCF7 cells incubated for 48 hrs Antiproliferative activity against human MCF7 cells incubated for 48 hrs	[PMID: 32139325]
MCF7	IC₅₀	16.7 3 Compound: 1	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30201293]
NCI-H460	IC₅₀	66 3 Compound: 1	Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 30201293]
NCI-H460	IC₅₀	67.5 3 Compound: 1	Antiproliferative activity against human NCI-H460 cells incubated for 48 hrs Antiproliferative activity against human NCI-H460 cells incubated for 48 hrs	[PMID: 32139325]
MCF7	IC₅₀	17.9 3 Compound: 1	Antiproliferative activity against human MCF7 cells incubated for 48 hrs Antiproliferative activity against human MCF7 cells incubated for 48 hrs	[PMID: 32139325]
NCI-H460	IC₅₀	67.5 3 Compound: 1	Antiproliferative activity against human NCI-H460 cells incubated for 48 hrs Antiproliferative activity against human NCI-H460 cells incubated for 48 hrs	[PMID: 32139325]
U-87MG ATCC	IC₅₀	103.8 3 Compound: 1	Antiproliferative activity against human U87MG cells after 48 hrs by MTT assay Antiproliferative activity against human U87MG cells after 48 hrs by MTT assay	[PMID: 30201293]
RKO	IC₅₀	17 3 Compound: SPA	Antiproliferative activity against human RKO cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human RKO cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37682035]
U-87MG ATCC	IC₅₀	96.5 3 Compound: 1	Antiproliferative activity against human U87MG cells incubated for 48 hrs Antiproliferative activity against human U87MG cells incubated for 48 hrs	[PMID: 32139325]
U-87MG ATCC	IC₅₀	103.8 3 Compound: 1	Antiproliferative activity against human U87MG cells after 48 hrs by MTT assay Antiproliferative activity against human U87MG cells after 48 hrs by MTT assay	[PMID: 30201293]
U-87MG ATCC	IC₅₀	96.5 3 Compound: 1	Antiproliferative activity against human U87MG cells incubated for 48 hrs Antiproliferative activity against human U87MG cells incubated for 48 hrs	[PMID: 32139325]
NCI-H460	IC₅₀	66 3 Compound: 1	Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 30201293]
NCI-H460	IC₅₀	67.5 3 Compound: 1	Antiproliferative activity against human NCI-H460 cells incubated for 48 hrs Antiproliferative activity against human NCI-H460 cells incubated for 48 hrs	[PMID: 32139325]
RKO	IC₅₀	17 3 Compound: SPA	Antiproliferative activity against human RKO cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human RKO cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37682035]
U-87MG ATCC	IC₅₀	103.8 3 Compound: 1	Antiproliferative activity against human U87MG cells after 48 hrs by MTT assay Antiproliferative activity against human U87MG cells after 48 hrs by MTT assay	[PMID: 30201293]
U-87MG ATCC	IC₅₀	96.5 3 Compound: 1	Antiproliferative activity against human U87MG cells incubated for 48 hrs Antiproliferative activity against human U87MG cells incubated for 48 hrs	[PMID: 32139325]

体外実験

Spinosad is a mixture of two natural occurring macrocyclic lactones (spinosyn A and spinosyn D) and acts primarily as a nAChR agonist^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

731.96

分子式

C₄₁H₆₅NO₁₀

CAS 番号

131929-60-7

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H]([C@H](CCC[C@@H](O1)CC)O[C@@H]2O[C@@H]([C@H](CC2)N(C)C)C)C)C3=C[C@@]([C@](C=C[C@]4([H])C5)([H])[C@]3([H])CC1=O)([H])[C@]4([H])C[C@@H]5O[C@H]6[C@@H]([C@@H]([C@H]([C@@H](O6)C)OC)OC)OC

Structure Classification

Initial Source

Microorganisms

Saccharopolyspora spinosa

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (136.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3662 mL	6.8310 mL	13.6619 mL
5 mM	0.2732 mL	1.3662 mL	2.7324 mL
10 mM	0.1366 mL	0.6831 mL	1.3662 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.93%

Select Batch:

データシート (274 KB) SDS (597 KB)

COA (255 KB) HNMR (301 KB) RP-HPLC (255 KB) MS (69 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Hak Joong Kim, et al. Biosynthesis of spinosyn in Saccharopolyspora spinosa: synthesis of permethylated rhamnose and characterization of the functions of SpnH, SpnI, and SpnK. J Am Chem Soc. 2010 Mar 10;132(9):2901-3. [Content Brief]

[2]. D T Vo, et al. Insect nicotinic acetylcholine receptor agonists as flea adulticides in small animals. J Vet Pharmacol Ther. 2010 Aug;33(4):315-22. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3662 mL	6.8310 mL	13.6619 mL	34.1549 mL
	5 mM	0.2732 mL	1.3662 mL	2.7324 mL	6.8310 mL
	10 mM	0.1366 mL	0.6831 mL	1.3662 mL	3.4155 mL
	15 mM	0.0911 mL	0.4554 mL	0.9108 mL	2.2770 mL
	20 mM	0.0683 mL	0.3415 mL	0.6831 mL	1.7077 mL
	25 mM	0.0546 mL	0.2732 mL	0.5465 mL	1.3662 mL
	30 mM	0.0455 mL	0.2277 mL	0.4554 mL	1.1385 mL
	40 mM	0.0342 mL	0.1708 mL	0.3415 mL	0.8539 mL
	50 mM	0.0273 mL	0.1366 mL	0.2732 mL	0.6831 mL
	60 mM	0.0228 mL	0.1138 mL	0.2277 mL	0.5692 mL
	80 mM	0.0171 mL	0.0854 mL	0.1708 mL	0.4269 mL
	100 mM	0.0137 mL	0.0683 mL	0.1366 mL	0.3415 mL

Spinosyn A Related Classifications

Others

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Spinosyn A131929-60-7InsecticideInhibitorinhibitorinhibit

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